The Relation of Calcium-to-Phosphorus Ratio to the Utilization of These Minerals by 18 Young College Women

Patton, Mary Brown; Wilson, Eva Donelson; Leichsenring, Jane M.; Norris, Loana M.; Dienhart, Charlotte M.

doi:10.1093/jn/50.3.373

Cited by 20 publications

(12 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of very high phosphorus to calcium dietary ratios has not been studied in detail; most of the studies performed with high phosphorus intake have been limited to calcium-phosphorus ratios of 1:3 to 1:5 and have shown no effect of the dietary phosphorus on calcium intake in the presence of normal renal function [2,11,18,27]. The effect of calcium phosphorus ratios of 1 : 30 and 1 : 40, such as was documented, is unknown.…”

Section: Combined Decrease Absorption and Decreased Dietary Calciummentioning

confidence: 99%

Nutritional and metabolic bone disease in a zoological population

et al. 1976

View full text Add to dashboard Cite

Abstract. The radiologic survey technique used atthe National Zoological Park has disclosed many cases of nutritional and metabolic bone disease of various types. This communication discusses calcium deficiency states seen in lion cubs associated with a meat diet, the increased need for calcium noted in egg-laying lizards, problems found in New World monkeys, antelopes (due to selenium and/or vitamin E deficiency), hypervitaminosis D, and lead poisoning noted in young primates. In all of these diagnoses, the use of routine radiographic studies has been extremely helpful, first in detecting that a bone or soft tissue abnormality is present, and then in the differential diagnosis of the etiology of this abnormality. As more is learned of the necessary nutriments for exotic species kept in captivity, it is expected that the nutritional disturbances described in this article will be seen with decreasing frequency.

show abstract

Section: Combined Decrease Absorption and Decreased Dietary Calciummentioning

confidence: 99%

Nutritional and metabolic bone disease in a zoological population

et al. 1976

View full text Add to dashboard Cite

show abstract

“…Twenty-two randomized intervention studies [14,20,53-72] (Table 2), two meta-analyses [27,29], and 12 prospective observational cohort studies (Table 3) [73-84] of the hypothesis met the inclusion criteria for at least one part of the study. Nineteen in-vitro animal bone mechanism studies were located [85-103].…”

Section: Resultsmentioning

confidence: 99%

“…Nineteen in-vitro animal bone mechanism studies were located [85-103]. The outcomes in the randomized intervention studies included: two examined changes of bone mineral density (BMD) [65,68], 15 examined calcium absorption and/or balance [14,20,53,55-62,67,69-71], five examined changes of urine calcium without calcium balance [54,63,64,66,72], 12 examined changes in BR markers [14,57,59-61,65,67-72], and none reported fractures or bone strength. The 12 prospective observational (cohort) studies examined fractures [73,74,80,81] and/or changes of BMD [75-79,82-84].…”

Section: Resultsmentioning

confidence: 99%

“…In a meta-analysis of the influence of phosphate supplements on calcium metabolism, limited to randomized studies that followed the recommendations of the Institute of Medicine for calcium balance studies [39], only one study met the inclusion criteria [53]. This cross-over study randomized young adult women to two phosphate doses (300 mg = 10 mmol and 600 mg = 20 mmol) stratified by calcium intakes of 344 mg (9 mmol) (basal diet) or with calcium supplements of 600 (15 mmol) or 1200 mg (30 mmol) per day.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Causal assessment of dietary acid load and bone disease: a systematic review & meta-analysis applying Hill's epidemiologic criteria for causality

Fenton

Tough

Lyon

et al. 2011

Nutr J

103

View full text Add to dashboard Cite

BackgroundModern diets have been suggested to increase systemic acid load and net acid excretion. In response, alkaline diets and products are marketed to avoid or counteract this acid, help the body regulate its pH to prevent and cure disease. The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill's criteria.MethodsSystematic review and meta-analysis. We systematically searched published literature for randomized intervention trials, prospective cohort studies, and meta-analyses of the acid-ash or acid-base diet hypothesis with bone-related outcomes, in which the diet acid load was altered, or an alkaline diet or alkaline salts were provided, to healthy human adults. Cellular mechanism studies were also systematically examined.ResultsFifty-five of 238 studies met the inclusion criteria: 22 randomized interventions, 2 meta-analyses, and 11 prospective observational studies of bone health outcomes including: urine calcium excretion, calcium balance or retention, changes of bone mineral density, or fractures, among healthy adults in which acid and/or alkaline intakes were manipulated or observed through foods or supplements; and 19 in vitro cell studies which examined the hypothesized mechanism. Urine calcium excretion rates were consistent with osteoporosis development; however calcium balance studies did not demonstrate loss of whole body calcium with higher net acid excretion. Several weaknesses regarding the acid-ash hypothesis were uncovered: No intervention studies provided direct evidence of osteoporosis progression (fragility fractures, or bone strength as measured using biopsy). The supporting prospective cohort studies were not controlled regarding important osteoporosis risk factors including: weight loss during follow-up, family history of osteoporosis, baseline bone mineral density, and estrogen status. No study revealed a biologic mechanism functioning at physiological pH. Finally, randomized studies did not provide evidence for an adverse role of phosphate, milk, and grain foods in osteoporosis.ConclusionsA causal association between dietary acid load and osteoporotic bone disease is not supported by evidence and there is no evidence that an alkaline diet is protective of bone health.

show abstract

“…So, additional variables may influence the relationship between dietary phosphate intake and bone health. Calcium intakes are, that is whether calcium intakes are limited or insufficient, might influence the relationship between phosphate, the diet acid load, and bone health [20,21]. Alkaline phosphates has been clinically available for several years as a marker for hone metabolism serum alkaline phosphatase consists of several dimeric isoforms that originate from various tissues such as liver, bone, intestine, spleen, kidney, and placenta.…”

Section: Introductionmentioning

confidence: 99%

Estimation of Some Mineral (Calcium, Phosphorous, Vitamin 25(OH) D, And Alkaline Phosphatase) in Osteoporosis Patients In Kirkuk City

Ali¹

2018

J Osteopor Phys Act

View full text Add to dashboard Cite

The Relation of Calcium-to-Phosphorus Ratio to the Utilization of These Minerals by 18 Young College Women

Cited by 20 publications

References 3 publications

Nutritional and metabolic bone disease in a zoological population

Nutritional and metabolic bone disease in a zoological population

Causal assessment of dietary acid load and bone disease: a systematic review & meta-analysis applying Hill's epidemiologic criteria for causality

Estimation of Some Mineral (Calcium, Phosphorous, Vitamin 25(OH) D, And Alkaline Phosphatase) in Osteoporosis Patients In Kirkuk City

Contact Info

Product

Resources

About