The relation between urinary metabolite of pyrethroid insecticides and semen quality in humans

Analysis and evaluation of pyrethroid exposure in human population based on biological monitoring of urinary pyrethroid metabolites

“…Two studies on Chinese men diagnosed with unexplained male-factor infertility reported that urinary PYR metabolites were associated with altered semen quality, increased serum luteinizing hormone and reduced serum estradiol levels. 13,16) Meeker et al 14,15) reported that increased sperm DNA damage identified by comet assay, and reduced serum inhibin B and testosterone may relate to urinary PYR metabolites among the US general population. These lines of evidence suggest that long-term PYR exposure might induce adverse effects in the reproductive system of adult men, although the dose-response relationship of the above findings should be investigated further.…”

“…[9][10][11][12] More recently, some researchers have reported the relationship between urinary metabolite levels and several adverse health outcomes in epidemiological studies. [13][14][15][16] In this review, the biological monitoring of PYR in the general population and its limitations will be discussed.…”

Evaluation of Urinary Pesticide Biomarkers among a Sample of the Population in the United States

“…However, because of the rapid metabolism of the compounds, pyrethroids are not believed to result in neurological signs from chronic, low-level exposures [46]. There has also been an attempt to correlate pyrethroids exposure to reduction in semen and hormone levels in adult men [20,47].…”

Overview of developmental and reproductive toxicity research in china: History, funding mechanisms, and frontiers of the research

“…In a retrospective cohort study among female workers employed in a Shanghai textile industry, Wong et al (2009) found that occupational exposure to synthetic fibers may cause miscarriages. Xia et al (2008) investigated the possible association between internal exposure levels of 3-phenoxybenzoic acid (3-PBA), a urinary metabolite of pyrethroids, and altered semen quality in Chinese men. Xia et al (2008) reported that there was suggestive evidence showing an association between increased creatinine-adjusted 3-PBA quartiles and sperm concentration, whereas sperm volume, sperm number per ejaculum, and sperm motility were weakly or nonsignificantly associated with 3-PBA quartiles.…”

“…Xia et al (2008) investigated the possible association between internal exposure levels of 3-phenoxybenzoic acid (3-PBA), a urinary metabolite of pyrethroids, and altered semen quality in Chinese men. Xia et al (2008) reported that there was suggestive evidence showing an association between increased creatinine-adjusted 3-PBA quartiles and sperm concentration, whereas sperm volume, sperm number per ejaculum, and sperm motility were weakly or nonsignificantly associated with 3-PBA quartiles. Tang et al (2008) reported an association between prenatal exposure to coal-burning pollutants (measured by levels of PAH-DNA adducts, lead, and mercury in umbilical cord blood) and child development measured by the Gesell Developmental Schedules at 2 years of age in a 2002 cohort.…”