The Relation between the Minor Components of Whole Normal Human Adult Hemoglobin as Isolated by Chromatography and Starch Block Electrophoresis

Schnek, Arthur G.; Schroeder, W. A.

doi:10.1021/ja01467a046

Cited by 148 publications

(49 citation statements)

References 1 publication

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“…In our laboratory, this method detects norepinephrine levels as low as 10 pg/ml, with a coefficient of variation of 5.6%. Hemoglobin Al levels were measured spectrophotometrically with a commercial kit (Quik-Sep; Isolab, Inc., Akron, OH) based on a method developed by Schroeder and co-workers (19). This measurement provides a reliable indication of the long-term quality of diabetic control (20).…”

Section: Methodsmentioning

confidence: 99%

Baroreflex control of plasma norepinephrine and heart period in healthy subjects and diabetic patients.

Eckberg¹,

Harkins²,

Fritsch³

et al. 1986

J. Clin. Invest.

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Resting diabetic patients may have excessively rapid heart rates, reduced heart rate variability, and subnormal plasma catecholamine levels. Although all of these abnormalities may relate in some way to baroreceptor reflex function, there have been surprisingly few attempts to evaluate systematically baroreflex mechanisms in diabetic patients. Accordingly, we studied autonomic responses over a range of pharmacologically induced arterial pressure changes in 10 unselected young adult insulindependent diabetic patients who had no symptoms of autonomic neuropathy, and 12 age-matched nondiabetic subjects. Sympathetic responses were estimated from antecubital vein plasma norepinephrine levels, and parasympathetic responses were estimated from electrocardiographic R-R intervals and their variability (standard deviation). Both were correlated with other noninvasive indexes of peripheral and central nervous system function. Multiple derangements of baroreflex function were found in the diabetic patients studied. Sympathetic abnormalities included subnormal baseline norepinephrine levels, virtual absence of changes of norepinephrine levels during changes of arterial pressure, and supranormal pressor responses to phenylephrine infusions. Parasympathetic abnormalities included subnormal baseline standard deviations of R-R intervals, and R-R interval prolongations during elevations ofarterial pressure which were unmistakably present, but subnormal. Our data suggest that in diabetic patients, subnormal baseline plasma norepinephrine levels may signify profound, possibly structural defects of sympathetic pathways. Subnormal resting levels of respiratory sinus arrhythmia may have different implications, however, since vagal, unlike sympathetic reflex abnormalities, can be reversed partly by arterial pressure elevations.

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Section: Methodsmentioning

confidence: 99%

Baroreflex control of plasma norepinephrine and heart period in healthy subjects and diabetic patients.

Eckberg¹,

Harkins²,

Fritsch³

et al. 1986

J. Clin. Invest.

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show abstract

“…12 Then between 1958 and 1961, Allen, Schroeder and colleagues chromatographically separated several fast moving minor Hb components in red cell haemolysates from healthy adults. [13][14][15][16] They were called minor hemoglobins or fast hemoglobins because of their fast migration in electrophoretic field. They were described as HbA1a, HbA1b, HbA1c, in the order in which they were eluted.…”

Section: Glycosylated Hemoglobin (Hba1c)mentioning

confidence: 99%

Prevalence of undiagnosed diabetes and prediabetes among voluntary blood donors in a tertiary health care setting

Ramasamy

Parthasarathy

2016

Int J Res Med Sci

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“…The adult form of hemoglobin Hasharon was chromatographically prepared on an IRC column (14,25). The hemolysate was first dialyzed against Developer 6; the same solution was employed to pre-equilibrate the column.…”

Section: Methodsmentioning

confidence: 99%

Hemoglobin Hasharon in a Premature Infant with Hemolytic Anemia

et al. 1975

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The Relation between the Minor Components of Whole Normal Human Adult Hemoglobin as Isolated by Chromatography and Starch Block Electrophoresis

Cited by 148 publications

References 1 publication

Baroreflex control of plasma norepinephrine and heart period in healthy subjects and diabetic patients.

Baroreflex control of plasma norepinephrine and heart period in healthy subjects and diabetic patients.

Prevalence of undiagnosed diabetes and prediabetes among voluntary blood donors in a tertiary health care setting

Hemoglobin Hasharon in a Premature Infant with Hemolytic Anemia

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