The relation between submaximal aerobic exercise improving vascular elasticity through loss of visceral fat and antihypertensive

Fang, Hong; Liu, Chi; Cavdar, Omer

doi:10.1080/10641963.2020.1847127

Cited by 3 publications

(3 citation statements)

References 49 publications

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“…It is crucial for obese patients who have lost weight to maintain their status, as weight regaining worsens AS with a significant increase in PWV, especially in patients with obesity and MS [ 56 ]. Moreover, it is important to pay particular attention to patients with MS and AS in whom the adverse effect of metabolic disturbances on arterial function can be offset by an adequate program of exercises, which includes mainly aerobic physical training [ 109 , 110 ].…”

Section: Importance Of Analyzed Research In Routine Clinical Practicementioning

confidence: 99%

Arterial Stiffness Assessment by Pulse Wave Velocity in Patients with Metabolic Syndrome and Its Components: Is It a Useful Tool in Clinical Practice?

Starzak

Stanek

Jakubiak

et al. 2022

IJERPH

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Metabolic syndrome (MS) is not a single disease but a cluster of metabolic disorders associated with increased risk for development of diabetes mellitus and its complications. Currently, the definition of MS published in 2009 is widely used, but there are more versions of the diagnostic criteria, making it difficult to conduct scientific discourse in this area. Increased arterial stiffness (AS) can predict the development of cardiovascular disease both in the general population and in patients with MS. Pulse wave velocity (PWV), as a standard method to assess AS, may point out subclinical organ damage in patients with hypertension. The decrease in PWV level during antihypertensive therapy can identify a group of patients with better outcomes independently of their reduction in blood pressure. The adverse effect of metabolic disturbances on arterial function can be offset by an adequate program of exercises, which includes mainly aerobic physical training. Non-insulin-based insulin resistance index can predict AS due to a strong positive correlation with PWV. The purpose of this paper is to present the results of the review of the literature concerning the relationship between MS and its components, and AS assessed by PWV, including clinical usefulness of PWV measurement in patients with MS and its components.

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Section: Importance Of Analyzed Research In Routine Clinical Practicementioning

confidence: 99%

Arterial Stiffness Assessment by Pulse Wave Velocity in Patients with Metabolic Syndrome and Its Components: Is It a Useful Tool in Clinical Practice?

Starzak

Stanek

Jakubiak

et al. 2022

IJERPH

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“…Data on the effects of exercise training in patients with hypertension is limited. However, one study of 156 hypertensive patients randomized to 12 months of exercise training or usual care found 30% reduction in visceral fat area on B-mode ultrasound compared to no effect with antihypertensive pharmacotherapy alone ( 139 ). Meta-analyses of the effect of exercise training on visceral fat in both overweight adults and patients with type 2 diabetes mellitus suggest that aerobic exercise training (but not resistance training) appears to provide the greatest benefits ( 140 ) ( Table 3 ).…”

Section: Exercise Training Effects On Cardiac and Extra-cardiac Tissu...mentioning

confidence: 99%

A Contemporary Review of the Effects of Exercise Training on Cardiac Structure and Function and Cardiovascular Risk Profile: Insights From Imaging

Alhumaid

Small

Kirkham

et al. 2022

Front. Cardiovasc. Med.

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Exercise is a commonly prescribed therapy for patients with established cardiovascular disease or those at high risk for de novo disease. Exercise-based, multidisciplinary programs have been associated with improved clinical outcomes post myocardial infarction and is now recommended for patients with cancer at elevated risk for cardiovascular complications. Imaging studies have documented numerous beneficial effects of exercise on cardiac structure and function, vascular function and more recently on the cardiovascular risk profile. In this contemporary review, we will discuss the effects of exercise training on imaging-derived cardiovascular outcomes. For cardiac imaging via echocardiography or magnetic resonance, we will review the effects of exercise on left ventricular function and remodeling in patients with established or at risk for cardiac disease (myocardial infarction, heart failure, cancer survivors), and the potential utility of exercise stress to assess cardiac reserve. Exercise training also has salient effects on vascular function and health including the attenuation of age-associated arterial stiffness and thickening as assessed by Doppler ultrasound. Finally, we will review recent data on the relationship between exercise training and regional adipose tissue deposition, an emerging marker of cardiovascular risk. Imaging provides comprehensive and accurate quantification of cardiac, vascular and cardiometabolic health, and may allow refinement of risk stratification in select patient populations. Future studies are needed to evaluate the clinical utility of novel imaging metrics following exercise training.

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“…PWV refers to the conduction velocity of the pressure wave propagating along the wall of the aorta with each pulse ejection, and it is a non-invasive index for evaluating the stiffness of arterial vessels, and PWV measurements are considered more sensitive than conventional blood pressure measurements ( 16 ). Theoretically, increased arterial stiffness is related to the loss of arterial elasticity and decreased compliance, and increased blood pressure will lead to vascular wall remodeling and vascular dysfunction, in order to compensate for changes in vascular wall stress, thus further aggravating arterial stiffness ( 17 ). Therefore, improving vascular function is essential for management and prevention strategies in patients with pre-hypertension and hypertension.…”

Section: Introductionmentioning

confidence: 99%

Effect of exercise on vascular function in hypertension patients: A meta-analysis of randomized controlled trials

Zhou

Wang

Zhao³

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveThe purpose of this study was to systematically evaluate the effect of exercise on vascular function in patients with pre- and hypertension.MethodsA systematic review of articles retrieved via the PubMed, Embase, EBSCO, and Web of Science databases was conducted. All the randomized controlled trials published between the establishment of the databases and October 2022 were included. Studies that evaluated the effects of exercise intervention on vascular function in patients with pre- and hypertension were selected.ResultsA total of 717 subjects were included in 12 randomized controlled trials. The meta-analysis showed that in patients with pre- and hypertension, exercise can significantly reduce systolic blood pressure (SBP) (MD = –4.89; 95% CI, –7.05 to –2.73; P < 0.00001) and diastolic blood pressure (DBP) (MD = –3.74; 95% CI, –5.18 to –2.29; P < 0.00001) and can improve endothelium-dependent flow-mediated dilatation (MD = 2.14; 95% CI, 1.71–2.61; P < 0.00001), and exercise did not reduce pulse wave velocity (PWV) (MD = 0.03, 95% CI, –0.45–0.50; P = 0.92). Regression analysis showed that changes in exercise-related vascular function were independent of subject medication status, baseline SBP, age and duration of intervention.ConclusionAerobic, resistance, and high-intensity intermittent exercise all significantly improved SBP, DBP, and FMD in pre- and hypertensive patients, however, they were not effective in reducing PWV, and this effect was independent of the subject’s medication status, baseline SBP, age and duration of intervention.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022302646.

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The relation between submaximal aerobic exercise improving vascular elasticity through loss of visceral fat and antihypertensive

Cited by 3 publications

References 49 publications

Arterial Stiffness Assessment by Pulse Wave Velocity in Patients with Metabolic Syndrome and Its Components: Is It a Useful Tool in Clinical Practice?

Arterial Stiffness Assessment by Pulse Wave Velocity in Patients with Metabolic Syndrome and Its Components: Is It a Useful Tool in Clinical Practice?

A Contemporary Review of the Effects of Exercise Training on Cardiac Structure and Function and Cardiovascular Risk Profile: Insights From Imaging

Effect of exercise on vascular function in hypertension patients: A meta-analysis of randomized controlled trials

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