The relation between serum D-dimer, ferritin and vitamin D levels, and dysgeusia symptoms, in patients with coronavirus disease 2019

Elibol, Elif; Baran, Hacer

doi:10.1017/s0022215120002765

Cited by 12 publications

(12 citation statements)

References 23 publications

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“…In another study, Elibol and Baran 23 analysed the relationship between D-dimer and ferritin and Covid-19 related gustatory dysfunctions. As noted by Benkirane et al .…”

Section: Discussionmentioning

confidence: 99%

Systemic inflammatory markers and psychophysical olfactory scores in coronavirus disease 2019 patients: is there any correlation?

et al. 2021

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Objective To analyse the correlations between olfactory psychophysical scores and the serum levels of D-dimer, C-reactive protein, ferritin, lactate dehydrogenase, procalcitonin and neutrophil-to-lymphocyte ratio in coronavirus disease 2019 patients. Methods Patients underwent psychophysical olfactory assessment with the Connecticut Chemosensory Clinical Research Center test, and determination of blood serum levels of the inflammatory markers D-dimer, C-reactive protein, ferritin, lactate dehydrogenase, procalcitonin and neutrophil-to-lymphocyte ratio within 10 days of the clinical onset of coronavirus disease 2019 and 60 days after. Results Seventy-seven patients were included in this study. D-dimer, procalcitonin, ferritin and neutrophil-to-lymphocyte ratio correlated significantly with severe coronavirus disease 2019. No significant correlations were found between baseline and 60-day Connecticut Chemosensory Clinical Research Center test scores and the inflammatory markers assessed. Conclusion Olfactory disturbances appear to have little prognostic value in predicting the severity of coronavirus disease 2019 compared to D-dimer, ferritin, procalcitonin and neutrophil-to-lymphocyte ratio. The lack of correlation between the severity and duration of olfactory disturbances and serum levels of inflammatory markers seems to further suggest that the pathogenetic mechanisms underlying the loss of smell in coronavirus disease 2019 patients are related to local rather than systemic inflammatory factors.

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“…In another study, Elibol and Baran 23 analysed the relationship between D-dimer and ferritin and Covid-19 related gustatory dysfunctions. As noted by Benkirane et al .…”

Section: Discussionmentioning

confidence: 99%

Systemic inflammatory markers and psychophysical olfactory scores in coronavirus disease 2019 patients: is there any correlation?

et al. 2021

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“…Alcohol consumption, antidepressant use and diet have not been directly studied in association with taste loss. Vitamin D levels have been found to be significantly different in those with or without taste loss in COVID-19 [55]. Regarding BMI, the duration of taste loss did not significantly differ between overweight/obese and normal weight participants, although those with higher BMI did appear to have a greater frequency of taste loss but not smell loss [56].…”

Section: Differences Between Prolonged and Rapid Taste Recoverymentioning

confidence: 92%

COVID-19 Induced Taste Dysfunction and Recovery: Association with Smell Dysfunction and Oral Health Behaviour

Catton

Gardner

2022

Medicina

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Background and Objectives: Disruption to taste and smell are common symptoms of COVID-19 infection. The current literature overlooks taste symptoms and tends to focus on the sense of smell. Persisting cases (>28 days) of taste dysfunction are increasingly recognised as a major future healthcare challenge. This study focuses on the severity and recovery of COVID-19 induced taste loss and association with olfactory symptoms, lifestyle and oral health factors. Materials and Methods: This study was a cross-sectional survey comparing 182 rapid taste recovery participants (≤28 days) with 47 participants with prolonged taste recovery >28 days. Analyses of taste loss in association with smell loss, age, sex, illness severity, diet, BMI, vitamin-D supplementation, antidepressants, alcohol use, smoking, brushing frequency, flossing, missing teeth, appliances and number of dental restorations were conducted. Differences in the severity of the loss of sour, sweet, salt, bitter and umami tastes were explored. Results: Both the severity and the duration of taste and smell loss were closely correlated (p < 0.001). Salt taste was significantly less affected than all other taste qualities (p < 0.001). Persisting taste loss was associated with older age (mean ± 95% CI = 31.73 ± 1.23 years vs. 36.66 ± 3.59 years, p < 0.001) and reduced likelihood of using floss (odds ratio ± 95% CI = 2.22 (1.15–4.25), p = 0.047). Conclusions: Smell and taste loss in COVID-19 are closely related, although a minority of individuals can experience taste or smell dysfunction in the absence of the other. The taste of salt may be less severely affected than other taste qualities and future work exploring this finding objectively is indicated. The association of flossing with rapid taste recovery adds to the growing evidence of a link between good periodontal health and favourable COVID-19 outcomes.

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“…A total of 2235 articles were screened, scrutinized 109 full-text articles, and ultimately 26 studies met the inclusion criteria for meta-analysis (Figure 1). Those studies documented patients with and without olfactory and gustatory dysfunction(Le Sanli et al, 2021;Rojas-Lechuga et al, 2021;Sayın et al, 2021;Dev et al, 2021;Sheng et al, 2021;Elibol and Baran, 2021;Samimi et al, 2021;Sahoo et al, 2021;Singer-Cornelius et al, 2021;Porta-Etessam et al, 2021;Gupta et al, 2021;Soh et al, 2021;Tabari et al, 2021;Jain et al, 2021;Lee et al, 2021;Cheng et al, 2021;Ahn and Min, 2021;Klopfenstein et al, 2020;Lv et al, 2020;Jalessi et al, 2020;Petrocelli et al, 2020;Prajapati et al, 2020;Shah et al, 2020;Altundag et al, 2020;Tham et al, 2020).The 83 excluded articles and the reasons for exclusion are 6 provided in Table 2 in the Supplement.…”

Section: Resultsmentioning

confidence: 99%

Systematic review and meta-analysis of olfactory and gustatory dysfunction in COVID-19

Liu

Yang

Zhang

et al. 2022

International Journal of Infectious Diseases

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Background Chemosensory disorders associated with coronavirus disease 2019 (COVID-19) have been widely mentioned during the pandemic. We performed a meta-analysis to assess the risk factors for olfactory and gustatory dysfunction in patients with COVID-19. Methods Three databases (PubMed, Embase, and Cochrane Library) were searched for studies published between December 1st, 2019 to August 31st, 2021. Select random effects model or fixed effects model to pool data based on heterogeneity. The results were reported as odds ratios or standardized mean differences and the corresponding 95% confidence intervals. Heterogeneity was reported as I 2 . Results Twenty-six studies with a total of 13813 patients were included. The pooled data indicated that sex (OR, 1.47; 95% CI, 0.93-2.31), age (SMD, -5.80; 95% CI, −13.35-1.75), smoking (OR, 2.04; 95% CI, 0.72-5.79), and comorbidity (OR, 1.21; 95% CI, 0.58-2.53) of COVID-19 patients had no effect on gustatory dysfunction. Olfactory dysfunction was more likely to occur in elderly patients with COVID-19 (SMD, -5.22; 95% CI, −8.28- −2.16). And COVID-19 patients with nasal congestion (OR, 3.41;95%CI, 2.30-5.06) and rhinorrhea (OR, 2.35; 95%CI, 1.60-3.45) are more prone to olfactory dysfunction. Conclusion These findings emphasize that elderly COVID-19 patients are more likely to suffer from olfactory dysfunction. Symptoms of nasal congestion and rhinorrhea may affect the recognition of olfactory dysfunction.

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The relation between serum D-dimer, ferritin and vitamin D levels, and dysgeusia symptoms, in patients with coronavirus disease 2019

Cited by 12 publications

References 23 publications

Systemic inflammatory markers and psychophysical olfactory scores in coronavirus disease 2019 patients: is there any correlation?

Systemic inflammatory markers and psychophysical olfactory scores in coronavirus disease 2019 patients: is there any correlation?

COVID-19 Induced Taste Dysfunction and Recovery: Association with Smell Dysfunction and Oral Health Behaviour

Systematic review and meta-analysis of olfactory and gustatory dysfunction in COVID-19

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