The Relation Between Maternal Serum Alpha‐fetoprotein Levels and Fetomaternal Haemorrhage

Hay, D. L.; Barrie, Jean U.; Davison, G.; Buttery, Beresford; Horacek, I.; Pepperell, R. J.; Fliegner, John R.

doi:10.1111/j.1471-0528.1979.tb10802.x

Cited by 36 publications

(15 citation statements)

References 3 publications

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“…After amniocentesis, up to 20% of patients have evidence of fetomaternal hemorrhage by the KB test or increases in alpha fetoprotein levels (Hay et al , 1979; Dallaire et al , 1980; MacLennan et al , 1994). Samura and colleagues (2003) measured the amount of cff DNA in maternal circulation after amniocentesis and found that it increased significantly in 79% of post-procedure maternal samples.…”

Section: Introductionmentioning

confidence: 99%

Circulating cell‐free DNA levels increase variably following chorionic villus sampling

et al. 2010

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Objective Cell-free fetal DNA (cffDNA) in maternal plasma results from degradation of fetal and/or placental cells. Our objective was to determine if chorionic villus sampling (CVS) causes increased release of fetal and/or maternal DNA. Methods Fifty-two pregnant women were recruited prior to CVS, performed for clinical indications, at 10 5/7 to 13 2/7 weeks. Maternal blood was collected before and within 15 minutes after CVS. cffDNA was extracted from plasma. Real-time polymerase chain reaction (PCR) amplification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the Y chromosome sequence DYS1 were used as measures of total and fetal DNA, respectively. All samples were analyzed in triplicate without knowledge of fetal gender. Results Sensitivity of DYS1 detection in male fetuses was 100% (n=30); specificity in female fetuses was 100% (n=22). While a majority of women had >50% post-procedure increases in both fetal and total DNA, some showed post-procedure decreases. However, overall median proportional increases were not statistically significant. Gestational age (GA), placental location, and individual CVS operator did not correlate with changes in DNA levels. Conclusions While there were no statistically significant overall changes in DNA levels after CVS, as-yet undiscovered variables may influence the extent of post-procedure release of cell-free DNA in the circulation of pregnant women.

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Section: Introductionmentioning

confidence: 99%

Circulating cell‐free DNA levels increase variably following chorionic villus sampling

et al. 2010

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“…Study of the placenta both macroscopically, microscopically and by ultrasound scan has given some insight into the reasons why maternal serum AFP may be raised in association with a normally formed fetus. Any factor allowing feto‐maternal haemorrhage (i.e., a breakdown in the fetal maternal barrier, spontaneous or induced by CVS or amniocentesis) will cause an elevation of maternal serum AFP and indeed the level of maternal serum AFP provides a sensitive indication of this (Hay et al 1979; Fuhrmann et al 1988). Villous surface area increases throughout gestation in normal pregnancies (Boyd 1984), although the rate of growth decreases from 34 weeks.…”

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confidence: 99%

Why might maternal serum AFP be high in pregnancies in which the fetus is normally formed?

Boyd

1992

BJOG

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“…This hypothesis could and should be tested. An alternative hypothesis to explain the relationship between MSAFP and fetal growth could be based on the observation of spontaneous fetalmaternal hemorrhaging and elevated early mid-trimester maternal serum alpha-fetoprotein, as reported by HAY [11]. We are currently examining this possibility.…”

Section: Discussionmentioning

confidence: 99%

Maternal serum alpha-fetoprotein (MSAFP) and fetal growth

Mariona¹,

Hassan²,

Syner³

et al. 1984

Journal of Perinatal Medicine

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Maternal serum alpha-fetoprotein (MSAFP) is in pregnancies whose early mid-trimester MSAFP known to be elevated in fetal open neural tube values were greater than twice the median; these defects (NTD) [5,7,21,24]. It is used as an early infants were appropriate but not small for gestascreening method for this condition when meas-tional age. ured between 15 and 20 weeks of gestation and is None of the reported studies has examined the likelytobecomearoutinepartofprenatalcare.lt overall relationship, if any between early midis also elevated in multiple pregnancies [23], fetal trimester MSAFP and neonatal birth weight and demise [18], threatened abortion [22] and other gestational age. The purpose of this study is to fetal abnormalities, such as omphalocele, fetal determine if such relationships exist and whether bowel obstruction [6], congenital nephrotic syn-or not they may be useful in detecting risk for drome [17], trisomy 13 with cystic hygroma and altered growth or preterm delivery. TURNER'S syndrome [13]. In the non-pregnant state, serum AFP is elevated in primary hepatoma [1], embryonal cell carcinoma of the ovary [12], ataxia telangectasia and hepatitis [19]. Elevated mid-trimester alpha-fetoprotein (MSAFP)

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The Relation Between Maternal Serum Alpha‐fetoprotein Levels and Fetomaternal Haemorrhage

Cited by 36 publications

References 3 publications

Circulating cell‐free DNA levels increase variably following chorionic villus sampling

Circulating cell‐free DNA levels increase variably following chorionic villus sampling

Why might maternal serum AFP be high in pregnancies in which the fetus is normally formed?

Maternal serum alpha-fetoprotein (MSAFP) and fetal growth

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