Why might maternal serum AFP be high in pregnancies in which the fetus is normally formed?

Boyd, Patricia A.

doi:10.1111/j.1471-0528.1992.tb14461.x

Cited by 33 publications

(17 citation statements)

References 19 publications

(18 reference statements)

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“…Infants of mothers with hyperemesis have lower birth weights and the mothers are more likely to have infants that are small for gestational age (8). Although elevated maternal serum AFP level usually shows an elevated risk for neural tube defects, they are also related to adverse pregnancy outcomes such as preeclampsia, spontaneous abortion, preterm delivery, low birth weight, IUGR, oligohydramnios, placental abruption and stillbirth (9)(10)(11)(12), all of which are thought to be associated with abnormal placentation (13). In our study, a significant association between serum AFP values and IUGR was observed.…”

Section: Discussionmentioning

confidence: 99%

Second trimester serum alpha-fetoprotein level is a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum

Özkaya¹,

Çakır²,

Çınar³

et al. 2011

J Turkish German Gynecol Assoc

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Second trimester serum alpha-fetoprotein level is a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum Objective: The aim of this study was to determine the association between three parameters of second trimester serum secreening and preterm labor and intrauterine growth restriction (IUGR) in patients with hyperemesis gravidarum (HG). Material and Methods:A prospective study on 429 pregnancies with HG was designed to determine the association between alpha-fetoprotein (AFP), unconjugated estriol (uE3), human chorionic gonadotropin (HCG) and pregnancy prognosis in terms of preterm labor, IUGR and birth weight.Results: In our study group the mean age of patients was 25.4±3.8years. Mean birth weight was 3180±555 g. Mean AFP, uE3, hCG levels in the study group were 1.44±0. Abstract ÖzetOriginal Investigation 220 Content

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Section: Discussionmentioning

confidence: 99%

Second trimester serum alpha-fetoprotein level is a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum

Özkaya¹,

Çakır²,

Çınar³

et al. 2011

J Turkish German Gynecol Assoc

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“…Maternal and neonatal liver function studies were also normal. It has been suggested that unexplained abnormal levels of MSAFP and MShCG are a reflection of altered placental histology and placental function [13,14]. The striking elevation of MSAFP in this case is also interesting given the report of gestational trophoblastic disease and trisomy 8 mosaicism [15].…”

Section: Discussionmentioning

confidence: 70%

Extreme Elevation of Maternal Serum Alpha-Fetoprotein Associated with Mosaic Trisomy 8 in a Liveborn

Miller¹,

Stéphan

Hume

et al. 2001

Fetal Diagn Ther

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Constitutional mosaic trisomy 8 has been associated with syndromic dysmorphology, corneal opacities, leukemias, and trophoblastic disease. However, abnormal maternal serum alpha-fetoprotein (MSAFP) has not been reported in association with mosaic trisomy 8. Our case first presented for evaluation of an extremely elevated MSAFP with mild elevation of MShCG in an otherwise normal pregnancy: MSAFP 13.89 MoM, MShCG 3.57 MoM, and MSuE3 1.04 MoM. Fetal dysmorphism was limited to bilateral pyelectasis and a prominent third ventricle. Spontaneous labor at 38 weeks resulted in the birth of a 3,570-gram AGA male with APGARs 7¹/8⁵. The neonate had facial asymmetry, 5th finger clinodactyly, 2–3 toe syndactyly, undescended testicle, abnormal prepuce, and mild pyelectasis. CT scan revealed hypoplasia of the corpus callosum, while echocardiography demonstrated bicuspid aortic valve, and the neonatal karyotype (blood) returned 46,XY/47,XY+8. Evaluation at 3 months revealed more prominent facial asymmetry, plagiocephaly, plantar creases, descent of the testis, and mild developmental delay. Review of the literature does not include any previously reported maternal serum alpha-fetoprotein aberrations in mosaic trisomy 8.

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“…The mean maternal age and gestational age were 35.97 ± 6.37 years (range 17-46) and 20.8 ± 2.18 weeks (range [15][16][17][18][19][20][21][22][23][24][25][26] in the CC group, and 34.8 ± 5.87 years (range 16-45) and 19.1 ± 3.11 weeks (range 15-28) in the AC group, respectively (NS). The location of the placenta was anterior in 131 (48.9%) and 150 (43.48%), posterior in 103 (38.4%) and 152 (44.06%), and fundal or lateral (fundolateral) in 34 (12.7%) and 43 (12.46%) cases in the CC and AC groups, respectively (NS).…”

Section: Resultsmentioning

confidence: 98%

“…By 12-14 weeks, the fetal serum AFP level rises to 3-4 mg/ml and remains unchanged until week 30 [25,26]. The maternal total blood volume at week 20 is 4,600 ml [27] and the AFP level is 60-70 ng/ml [25,26].…”

Section: Determination and Calculation Of The Amount Of Fmtmentioning

confidence: 99%

Fetomaternal transfusion after amniocentesis and cordocentesis

et al. 2010

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Why might maternal serum AFP be high in pregnancies in which the fetus is normally formed?

Cited by 33 publications

References 19 publications

Second trimester serum alpha-fetoprotein level is a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum

Second trimester serum alpha-fetoprotein level is a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum

Extreme Elevation of Maternal Serum Alpha-Fetoprotein Associated with Mosaic Trisomy 8 in a Liveborn

Fetomaternal transfusion after amniocentesis and cordocentesis

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