The Relation Between Human Exposure to Mercury and Thyroid Hormone Status

Ursı́nyová, Monika; Uhnáková, Iveta; Serbin, Rastislav; Mašánová, Vlasta; Hušeková, Z.; Wsólová, Ladislava

doi:10.1007/s12011-012-9382-0

Cited by 17 publications

(2 citation statements)

References 28 publications

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“…Heavy metals in the water and in the atmosphere, which characterize the environmental pollution, are known to act as endocrine disruptors (ED), and, by inducing cell oxidative stress and altering the DNA, may promote malignant transformation. In particular, the mercury compounds induce severe toxic effects both in human and animal experimental models [3,4], behaving as ED even against thyroid tissue [5,6]. Moreover, high levels of Hg, recently detected together with other heavy metals in volcanic areas [7,8], have been suspected to play a co-causative role in the high incidence of thyroid cancer, as earlier proposed by Zaichick et al [9] However, to date, the molecular alterations occurring in thyroid cells exposed to environmental heavy metals, able to promote the transformation and/or the selective growth of neoplastic cells, are not known, as well as the doses and duration of exposure necessary for such an action [10].…”

Section: Introductionmentioning

confidence: 99%

Low Doses of Methylmercury Induce the Proliferation of Thyroid Cells In Vitro Through Modulation of ERK Pathway

Maggisano

Bulotta

Celano

et al. 2020

IJMS

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Exposure to environmental endocrine disruptors has been associated with an increased frequency of thyroid pathology. In this study, we evaluated the effects of various concentrations of methylmercury (MeHg) on immortalized, non-tumorigenic thyroid cells (Nthy-ori-3-1). Exposure to MeHg at 2.5 and 5 µM for 24 h caused a reduction in cell viability with a decrease of the cell population in sub-G0 phase, as detected by MTT and flow cytometry. Conversely, MeHg at the lower concentration of 0.1 µM increased the cell viability with a rise of G2/M phase. An immunoblot analysis showed higher expression levels of phospho-ERK and not of phospho-Akt. Further enhancement of the cell growth rate was observed after a prolonged exposure of the cells up to 18 days to MeHg 0.1 µM. The present findings demonstrate the toxicity of high concentrations of MeHg on thyroid cells, while showing that treatment with lower doses of Hg, as may occur after prolonged exposure to this environmental contaminant, exerts a promoting effect on thyroid cell proliferation, by acting on the ERK-mediated pro-oncogenic signal transduction pathway.

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Section: Introductionmentioning

confidence: 99%

Low Doses of Methylmercury Induce the Proliferation of Thyroid Cells In Vitro Through Modulation of ERK Pathway

Maggisano

Bulotta

Celano

et al. 2020

IJMS

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“…Most of the detected Hg in samples came from sea products, which are known to be a source of methylmercury (MeHg) ( Holmes et al, 2009;Olmedo et al, 2013). Different mechanisms of MeHg toxicity are discussed, like oxidative stress and the inhibition of macromolecule synthesis (Soldin et al, 2008).The role of Hg as an endocrine disruptor affecting thyroid hormones analysed and found to be is inversely associated with thyroid hormone blood levels by several studies (Soldin et al, 2008;Ursinyova et al, 2012;Chen et al, 2013).…”

Section: Mercurymentioning

confidence: 99%

Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk

Zidane¹,

Ren²,

Xhaard³

et al. 2019

Asian Pac J Cancer Prev

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Background:In French Polynesia, thyroid cancer mortality and incidence is reported to be the highest in the world. Excessive levels of non-essential trace elements (nETE) in the body are associated with several types of cancer.Objective:The present study aims to provide quantitative information on food contamination by mercury (Hg), lead (Pb), arsenic (As) and cadmium (Cd) in French Polynesia and its potential correlation with measurements performed in fingernails of Polynesians, and then to investigate the potential association between these nETE and different thyroid cancer risks. Methods:The study population included 229 interviewed cases and 373 interviewed controls We performed a descriptive analysis of Polynesian food and examined the association between thyroid cancer risk and daily intake levels of nETE and with fingernail nETE levels.Results:Hg contamination was mainly present in sea products, Pb contamination was present in almost all samples, Cd was detectable in starchy food and As was detectable in all sea products. No patient exceeded dietary contamination WHO limits for Pb, 2 participants exceeded it for Hg and 3 individuals (0.5%) for cadmium. In fingernail clippings, the most detectable pollutant was Pb (553 participants), then Hg (543 participants) then Cd (only in 130 participants). Thyroid cancer risk was increased more than 4 times by Pb daily intake in patients with a history of cancer in first-degree relatives than in ones without (p for interaction =0.01), and 2 times more in women with more than 3 pregnancies than in those with none or less (p for interaction =0.005); it was also increased following As intake by more than 30% in patients with a history of cancer in first-degree relatives than in ones without (p for interaction =0.05). Conclusion:Locally produced foods are not a source of nETE exposure in French Polynesia. Dieatry nETE exposure and fingernail nETE concentration are not associated to differentiated thyroid cancer risk. No correlation found between nETE dietary exposure and fingernail nETE concentration.

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Evaluation of the effects of chronic occupational exposure to metallic mercury on the thyroid parenchyma and hormonal function

Correia

Chammas

Zavariz

et al. 2019

Int Arch Occup Environ Health

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The Relation Between Human Exposure to Mercury and Thyroid Hormone Status

Cited by 17 publications

References 28 publications

Low Doses of Methylmercury Induce the Proliferation of Thyroid Cells In Vitro Through Modulation of ERK Pathway

Low Doses of Methylmercury Induce the Proliferation of Thyroid Cells In Vitro Through Modulation of ERK Pathway

Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk

Evaluation of the effects of chronic occupational exposure to metallic mercury on the thyroid parenchyma and hormonal function

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