The relation between epstein-barr virus antibodies and clinical symptomatology and immunodeficiency in patients with Hodgkin's disease

Mochanko, K; Fejes, M; Breazavscek, Dora Maria; Suarez, Argimiro; Bachmann, A E

doi:10.1002/1097-0142(197912)44:6<2065::aid-cncr2820440617>3.0.co;2-g

Cited by 19 publications

(8 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since Ig synthesis induced by PWM is subject to the regulatory activity of monocytes (21,22), the abnormality could be associated with an increase in the number of these cells relative to lymphocytes in MNC suspensions (23). Indeed, using monoclonal antibodies reactive with monocytic cells we could confirm a recent report showing higher concentrations of monocytes in Ficoll-Hypaque MNC suspensions from patients with HD than in controls (20 (27)(28)(29), and antibodies against Epstein-Barr and other viral antigens (30,31) in patients with HD. Depressed Ig synthesis after stimulation with PWM, associated with enhanced spontaneous IgG synthesis, has also been reported in patients with systemic lupus erythematosus (32,33) and Henoch-Sch6nlein purpura (34) and attributed to an excessive B cell stimulation in vivo (35)(36)(37)(38).…”

Section: Resultssupporting

confidence: 81%

Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.

Romagnani¹,

Prete²,

Maggi³

et al. 1983

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T The immunoglobulin-synthesizing activities of peripheral blood mononuclear cells from 57 untreated patients with Hodgkin's disease and 47 normal subjects were compared. Cumulative amounts of IgM and IgG synthesized and secreted by unstimulated and pokeweed mitogen-stimulated cells over a 7-d period were determined in a solid-phase radioimmunoassay. Synthesis of IgM in unstimulated cultures and of both IgM and IgG in cultures stimulated with pokeweed mitogen was markedly reduced in patients with Hodgkin's disease, whereas the mean level of the spontaneous IgG synthesis was enhanced. The degree and frequency of in vitro abnormalities were not influenced by disease stage or histology.Depression of pokeweed mitogen-induced immunoglobulin synthesis did not correlate with excessive number of monocytes and it was unaffected by removal of phagocytic cells or addition to the cultures of monocytes from normal individuals. On the other hand, monocytes isolated from blood of patients with Hodgkin's disease were even more effective than normal monocytes in supporting pokeweed mitogen-induced immunoglobulin synthesis by normal phagocyte-depleted mononuclear cells. Synthesis of both IgM and IgG induced by pokeweed mitogen remained subnormal after addition to patient B cell cultures of autologous irradiated T cells or allogeneic normal T lymphocytes. T cells from patients with Hodgkin's disease appeared at least as effective as normal T cells in helping pokeweed mitogen-induced immunoglobulin production by normal B cells. However, when normal T cells were co-cultured with B cells from patients with Hodgkin's disease, spontaneous IgG synthesis declined, whereas the addition of patient T cells

show abstract

Section: Resultssupporting

confidence: 81%

Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.

Romagnani¹,

Prete²,

Maggi³

et al. 1983

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…It is known that host factors, especially immunological responses, determine the outcome of EBV infection. Experimental and clinical evidence also supports the notion that EBV can become oncogenic in immunodeficient hosts [27][28][29][30]. It was of interest that T-cell immunity was found to be significantly diminished in several parameters in pediatric HP in our previous studies [8,13].…”

Section: Discussionsupporting

confidence: 52%

“…It has been well documented that patients with primary and secondary immunodeficiency syndromes are prone to EBV-associated lymphoproliferative disorders [ [27][28][29][30]. Our recent analysis revealed common and early exposure of healthy Turkish children to EBV and high anti-EBV-VCA antibodies in 94% of children with HD [24].…”

Section: Discussionmentioning

confidence: 83%

Zinc status in pediatric Hodgkin's disease (HD) in Turkey: Possible impact on the immune system

avdar

Babacan

nal

et al. 1997

J. Trace Elem. Exp. Med.

View full text Add to dashboard Cite

Plasma erythrocyte (RBC) and hair zinc (Zn) levels were measured with atomic absorption spectrophotometers in 40 untreated children with Hodgkin's disease (HD). The great majority of the patients belonged to low and average socioeconomic status. The mean blood and hair Zn values in the patients were significantly lower than those in controls (P < 0.001 and <0.01, respectively). Some of the T‐cell functions, particularly CD4 cells, were found to be diminished. Interestingly, there were no significant difference in Zn levels of patients between the two study periods in spite of some improvement in SES conditions and health care in Turkey. The present data support our earlier hypothesis that preexisting Zn deficiency due to “nutritional environment” may prepare a milieu favoring development of malignant lymphoma by suppression of T‐cell immunity. In addition, Epstein‐Barr Virus (EBV) was found to be associated with pediatric HD at serological and molecular levels. These findings also may suggest contributory role of EBV in this lymphoma. J. Trace Elem. Exp. Med. 10:191–196, 1997. © 1997 Wiley‐Liss, Inc.

show abstract

“…Both Hodgkin's disease and infectious mononucleosis occur preferentially in higher socioeconomic groups, for example (McMahon 1966;Gutensohn and Cole 1981), and the possibility of an independent association on this basis arises. Not all patients with Hodgkin's disease possess antibodies to EBV [infectious mononucleosis following Hodgkin's disease has been reported (Davidson and Lessles 1977)]; and whereas some patients with Hodgkin's disease may have elevated anti-VCA and anti-EBNA titres, this characteristic appears to be secondary to immunosuppression rather than indicating a direct association between Hodgkin's disease and EBV infection (Hesse et al 1977;Mochanko et al 1979). Neither EBV DNA nor EBNA has been detected in Hodgkin's tissue or cultured Reed-Sternberg cells (Nonoyama et al 1974;Gallo and Geimann 1981).…”

Section: Infectious Mononucleosis and Hodgkin's Diseasementioning

confidence: 99%

Infectious Mononucleosis

1989

Clinical Topics in Infectious Disease

View full text Add to dashboard Cite

Infectious mononucleosis is a clinical entity characterized by pharyngitis, cervical lymph node enlargement, fatigue and fever, which results most often from a primary Epstein-Barr virus (EBV) infection. EBV, a lymphocrytovirus and a member of the γ-herpesvirus family, infects at least 90% of the population worldwide, the majority of whom have no recognizable illness. The virus is spread by intimate oral contact among adolescents, but how preadolescents acquire the virus is not known. During the incubation period of approximately 6 weeks, viral replication first occurs in the oropharynx followed by viremia as early as 2 weeks before onset of illness. The acute illness is marked by high viral loads in both the oral cavity and blood accompanied by the production of immunoglobulin M antibodies against EBV viral capsid antigen and an extraordinary expansion of CD8 + T lymphocytes directed against EBV-infected B cells. During convalescence, CD8 + T cells return to normal levels and antibodies develop against EBV nuclear antigen-1. A typical clinical picture in an adolescent or young adult with a positive heterophile test is usually sufficient to make the diagnosis of infectious mononucleosis, but heterophile antibodies are not specific and do not develop in some patients especially young children. EBV-specific antibody profiles are the best choice for staging EBV infection. In addition to causing acute illness, long-term consequences are linked to infectious mononucleosis, especially Hodgkin lymphoma and multiple sclerosis. There is no licensed vaccine for prevention and no specific approved treatment. Future research goals are development of an EBV vaccine, understanding the risk factors for severity of the acute illness and likelihood of developing cancer or autoimmune diseases, and discovering anti-EBV drugs to treat infectious mononucleosis and other EBV-spurred diseases.

show abstract

The relation between epstein-barr virus antibodies and clinical symptomatology and immunodeficiency in patients with Hodgkin's disease

Cited by 19 publications

References 26 publications

Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.

Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.

Zinc status in pediatric Hodgkin's disease (HD) in Turkey: Possible impact on the immune system

Infectious Mononucleosis

Contact Info

Product

Resources

About