The Relation Between Diabetes Mellitus and Clinical Syphilis

Abstract

At first the fluid came from the needle under pressure, often flowing in a steady stream which rather rapidly decreased to a normal flow. We did not limit ourselves to a definite amount, but allowed the fluid to escape until the rate reached normal.In one case the delirium apparently began to return, leading us to repeat the puncture ; here there was no excessive pressure to the flow, and only a small amount was withdrawn. The symptoms increased no further, and the patient went on toward recovery.It is interesting to note that in the seven cases of delirium, four patients died, two developed empyema, one of these showing also myocardial weakness, and the remaining one had unresolved pneumonia with a greatly prolonged convalescence. In the cases which terminated fatally, death seemed to be the result of an overwhelming toxemia rather than a cardiac failure. The cases in which the patients recovered were extremely severe in type, and during the course of the disease the prognosis was so unfavorable that a successful termination was not expected. REPORT OF CASESCase 1. (H-64017).-The patient was admitted to the ward, Dec. 19, 1916, with lohar pneumonia of the left lower lohe of four days' duration. He was delirious on admission to a wild and maniacal degree. Two days after admission, lumhar puncture was performed. The fluid was under considerahle pressure ; 30 c.c. were removed. No laboratory report was made, as the test tube was broken. The delirium greatly diminished, changing from a wild, active type to a low muttering. • The patient died, Dec. 23, 1916. Case 2 (F-64061).-The patient was admitted, Dec. 22, 1916, with lohar pneumonia of the right middle and lower lobe of two days' duration. He developed a marked delirium four days later and a severe headache. Lumbar puncture was performed on the eighth day of the disease ; 65 c.c. of clear fluid were removed under great pressure. The laboratory reported that it was sterile, with negative Noguchi and Rivolta tests. The delirium was almost immediately relieved, and improvement in the general condition was marked. The patient developed empyema, was operated on, and was cured.Case 3 (C-64074).-The patient was admitted, Dec. 25, 1916, with no obtainable history. There was lohar pneumonia of the left upper lobe. He was widly delirious on admission. Lumbar puncture was performed three days later ; 35 c.c. of clear fluid under marked pressure were removed. The laboratory reported that it was sterile, with negative Noguchi and Constitutional Signs

Diagnostic and Therapeutic Approaches for a Diabetic Patient Presenting with Secondary Syphilis and Severe Odynophagia

“…association between syphilis and DM has been a point of debate for more than a century. Necropsy results from six patients with DM revealed signs of syphilis, leading to the conclusion at that time that syphilis was one of the causes of DM [14,15]. A more recent study also reported a higher prevalence of DM in patients with neurosyphilis compared to non-neurosyphilis patients, non-syphilis patients, and healthy individuals [16].…”

Association between neurosyphilis and diabetes mellitus: Resurgence of an old problem 神经梅毒与糖尿病的关系：“旧事”再现

“…However, since the 1940s, discussion about the association of syphilis with DM has been rare, let alone the relationship between NS and DM. Half a century ago, there were two main opinions on the relationship between syphilis and DM: a few studies reported that syphilis could directly or indirectly induce DM, whereas others did not think there was any association between the two conditions . Based on clinical observation and experience, we reinvestigated this issue from a new perspective: is there any association between NS and DM, not between syphilis and DM?…”

“…Half a century ago, there were two main opinions on the relationship between syphilis and DM: a few studies reported that syphilis could directly or indirectly induce DM, 19,20 whereas others did not think there was any association between the two conditions. [21][22][23] Based on clinical observation and experience, we reinvestigated this issue from a new perspective: is there any association between NS and DM, not between syphilis and DM? We found significantly higher FPG and HbA1c levels in patients with NS compared with the other three groups in the present study.…”

Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation

“…In transgenic mice carrying the carboxyl-terminus of the beta APP gene, Aβ is demonstrated not only in the brain, but also in the kidney and pancreas [ 89 - 91 ]. Formation of Aβ plaques is also observed in the pancreas in transgenic NORBA mice overexpressing human APP [ 92 ].…”

“…Circulating LPS is higher in diabetic subjects compared to non-diabetics [ 117 - 119 ]. The association of diabetes with tuberculosis, syphilis and leprosy is well known [ 89 , 90 , 120 - 127 ]. It is noteworthy that various bacterial and viral infections, including H. pylori, enteroviruses, rubella, mumps, rotavirus, parvovirus and cytomegalovirus (CMV) have been proposed as potential etiological factors in type 1 diabetes [ 128 - 130 ].…”