2016
DOI: 10.18632/aging.100921
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Abstract: Strong epidemiologic evidence and common molecular mechanisms support an association between Alzheimer's disease (AD) and type 2-diabetes. Local inflammation and amyloidosis occur in both diseases and are associated with periodontitis and various infectious agents. This article reviews the evidence for the presence of local inflammation and bacteria in type 2 diabetes and discusses host pathogen interactions in chronic inflammatory disorders. Chlamydophyla pneumoniae, Helicobacter pylori and spirochetes are de… Show more

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Cited by 61 publications
(46 citation statements)
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References 188 publications
(180 reference statements)
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“…It is well‐known that the islets are sensitive to inflammation and that auto‐immunity induces type 1 diabetes (Galleri et al., ). In addition, infection and inflammation lead to islet lesions and dysfunction, which increases the risk of T2DM (Donath et al., ; Miklossy and McGeer, ). Alcohol intake affects the immune system by deteriorating innate and adaptive immune responses, promoting proinflammatory immune responses and suppressing antiinflammatory cytokines (Szabo and Saha, ).…”
Section: Discussionmentioning
confidence: 99%
“…Similarities in molecular structures between amyloids of different species may be involved in the creation of these prion-like agents through molecular mimicry (100), raising concerns regarding the exposure of humans to various food sources and microbes that contain amyloids (104)(105)(106). Indeed, microbial amyloids interact with the amyloids of host systems (23,107), putatively providing some immune-evasive and survival strategies (31,108), and were suggested to contribute to the pathology of aggregation diseases (107,(109)(110)(111)(112)(113)(114)(115)(116)(117)(118). This might be related to the ability of seeds of amyloid fibrils from one species to nucleate monomers from another species (74,(119)(120)(121).…”
Section: Can Csga Influence Neurodegenerative Diseases?mentioning
confidence: 99%
“…The reason is well explained by the New Theory: gambling (or long work in the office) has an effect on the psyche, but the main thing is that the many hours accumulation of venous blood in the lower half of the body leads to its thrombosis and sudden death of a person due to blood clots entering the arteries. In addition, it can be safely assumed that infection, bacteria, AFO, oxidized forms of lipids and proteins from the stagnation zones along the bloodstream can penetrate the brain and cause Alzhei- Vladimir Ermoshkin (2017) [25,26,27], confirmed by some data, including my theory, obtained in recent years. It turns out that the laws of physics play a major role in the development of many CVDs!…”
Section: Resultsmentioning
confidence: 55%
“…These animals develop amyloid plaques in their brains and deficiencies in learning complex tasks. They exhibit increased immunoreactivity to amyloid β in neurons, the presence of extracellular plaques in the meninges, microgliosis, apoptosis, vascular activation of SOD, rupture of the blood-brain barrier and elevated brain levels of cholesterol; these data provide strong support for the suggestion that copper is implicated in the accumulation of Abfix [173].…”
Section: Sporadic Models For Alzheimer's Studymentioning
confidence: 57%
“…An article by Miklossy & McGeer reviewed the evidence for the presence of local inflammation and bacteria ( Chlamydophyla pneumoniae , H. pylori, and spirochetes) in Alzheimer's disease (AD) and type 2 diabetes. The presence of these bacteria was associated with dementia and brain lesions in AD and islet lesions in type 2 diabetes.…”
Section: Neurological Disordersmentioning
confidence: 99%