The relation between anxiety and BMI – is it all in our curves?

Haghighi, Mohammad; Jahangard, Leila; Ahmadpanah, Mohammad; Bajoghli, Hafez; Holsboer‐Trachsler, Edith; Brand, Serge

doi:10.1016/j.psychres.2015.12.002

Cited by 14 publications

(13 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9,10 In contemporary society, the mass media promote the distorted perception that being thin means being beautiful, especially in China. 15,16 In the study of the relationship between anxiety and BMI, several studies also identify gender as a seemingly significant variable. 11 Several meta-analyses and systematic reviews have shown a positive relationship between anxiety symptoms and obesity or being overweight.…”

mentioning

confidence: 99%

“…[12][13][14] However, several studies show that underweight and obese individuals experience more mental disorders, compared with their normal-weight and overweight counterparts. 15,16 In the study of the relationship between anxiety and BMI, several studies also identify gender as a seemingly significant variable. For example, a study reported a significant association between anxiety and underweight in female participants, but not in male participants.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Are overweight people more susceptible to anxiety?

Zhang

et al. 2018

Int J Geriat Psychiatry

View full text Add to dashboard Cite

Objectives This study aimed to investigate anxiety status and its relationship with body mass index (BMI) among empty nesters in China, so as to improve their quality of life and provide direction for further research. Methods A cross‐sectional survey was conducted among 4901 empty nesters in Shanxi, China. Anxiety, weight, height, depression, socio‐demographic variables, attention to daily nutritional health, social activities, and self‐care ability were evaluated in the study. T‐tests and chi‐square tests were used to compare differences in categorical and continuous variables. Binary logistic regression was performed to explore the association between anxiety and BMI among male and female empty nesters. Results The results showed that 44.5% of empty nesters reported anxiety, of which, 43.2% were male participants and 45.9% were female participants. After adjusting for other variables, overweight empty nesters odds ratio (OR; 95% confidence interval [CI]) = 0.813 (0.692‐0.954) were less likely to be anxious, compared with their normal‐weight counterparts. Gender was a significant factor in the relationship, with the negative association between overweight and anxiety only found in female empty nesters OR (95%CI) = 0.718 (0.572‐0.901). Income, education, complete self‐care ability, and depression showed significant associations with anxiety. Conclusion The prevalence of anxiety was high in the study population. Gender is a significant factor in the relationship between anxiety and BMI among empty nesters. The results intend to inform the government and media that overweight is a protective factor for anxiety among female empty nesters, necessitating a move toward eliminating weight bias.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Are overweight people more susceptible to anxiety?

Zhang

et al. 2018

Int J Geriat Psychiatry

View full text Add to dashboard Cite

show abstract

“…Previous observational and RCTs have presented conflicting evidence on the association between statins and depression. Several RCTs reported a clinically relevant improvement in depressive symptoms amongst patients that used statins alone or in combination with conventional SSRIs [18][19][20][21][22]. While a Swedish national cohort study reported that statin use was associated with an overall reduced depression risk [23], a large-scale observational study in Denmark found increased use of antidepressants and diagnosis of depression amongst statin users [25].…”

Section: Discussionmentioning

confidence: 99%

“…While the use of statins is generally safe, several unintended effects have been reported, including musculoskeletal complications and diabetes [17]. Furthermore, there is conflicting evidence on the anti-depressive effect of statins from observational studies and randomised controlled trials (RCT) [18][19][20][21][22][23][24][25][26][27]. This inconsistency in findings may be due to differences in the chemical and pharmacokinetic properties of the types of statins studied [28], or reflect bias from small sample sizes, short follow-up times and unmeasured confounders.…”

Section: Introductionmentioning

confidence: 99%

Statins and antidepressants induce similar in vitro gene expression responses

Jiang

Shah

2022

Preprint

View full text Add to dashboard Cite

Cholesterol-lowering statins, which are widely prescribed for treating and preventing cardiovascular diseases, have previously been reported to show anti-depressive properties. However, there is conflicting evidence on the association of statins with depression, and the molecular mechanisms that govern their potential anti-depressive effects remain largely veiled. We evaluated the anti-depressive activities of statins using a combined approach of transcriptomic signature matching and genetic association analysis. We interrogated pre-compiled Connectivity Map (CMap) perturbational gene expression signatures and found that compounds with highly similar signatures to statins (average connectivity score > 90) were enriched for antidepressants (p < 1E-05). Genes perturbed in the same direction by both statins and antidepressants were significantly enriched for various immune pathways, while genes perturbed in the opposite direction were enriched for lipid metabolism pathways. Using publicly available expression quantitative trait loci (eQTL) and genome-wide association summary data, we performed Mendelian randomisation analysis to infer association of genetically predicted statin target inhibition with various depression, immune and disease traits. Genetically proxied HMGCR inhibition was significantly associated with extensive changes in immune cell traits, particularly platelet-related indices, and while we observed no genetic association between HMGCR expression and depression risk (p = 0.21), we found nominal association with depression-related worrying symptoms (p = 0.042). Our analyses provide genomic evidence for the association between statins and extensive alterations in immune-related processes, which have been linked to depression. Our findings carry clinical relevance, both for treating the increasing prevalence of individuals with comorbid cardiovascular diseases and depression, and for exploring the potential of repurposing statins for modulating depression symptoms.

show abstract

“…28 On the other hand, a study conducted among adults in 2016 showed higher anxiety scores for medium to high BMI levels and an inverted U-shaped association for both low and very high BMI levels with anxiety. 29 For Saudis, it was found that almost half the 'Normal weight' group had the highest proportion of minimal anxiety as compared to about one-third in the obese group. The obese group was also found to have the highest proportion of mild and severe anxiety as compared to the other three BMI groups.…”

Section: Discussionmentioning

confidence: 99%

Obesity, Quality of Sleep and Anxiety in Saudi Arabia

Alhusseini

Elaasser

Alshaar

et al. 2021

J. Contemp. Med. Sci.

View full text Add to dashboard Cite

Objectives: The aim is to determine an association between obesity levels, quality of sleep, and anxiety among the Saudi population. Methods: A cross-sectional study was used by distributing an online questionnaire via social media channels to the Saudi population. We used the body mass index (BMI) to assess body fat, the Pittsburg Sleep Quality Index (PSQI), and Generalized Anxiety Disorder – 7 (GAD-7). Chi-square tests and logistic regression were used to test associations with a p-value of less than 0.05. Results: We received a total of 1123 respondents and the majority (61%) were obese and overweight. According to the GAD-7 score, 17% had severe anxiety; the PSQI score was 8.42 +3.45, indicating overall poor sleep quality. Underweight respondents had higher moderate (25%) and severe (26%) anxiety as compared to those with normal or higher BMI (14%-18%) (p=0.002). PSQI scores were higher for obese (8.9+3.6) and overweight (8.6+3.4) respondents as compared to underweight (7.5+3.0) (p=0.001). Persons with severe (10.4+3.6) or moderate (9.7+3.7) anxiety had higher PSQI scores as compared to those with minimal anxiety (6.8+2.7) (p<0.001). Conclusion: There is a relationship between obesity, sleep, and anxiety. Overweight and obesity were significantly associated with anxiety and poor sleep quality in Saudi Arabia.

show abstract

The relation between anxiety and BMI – is it all in our curves?

Cited by 14 publications

References 19 publications

Are overweight people more susceptible to anxiety?

Are overweight people more susceptible to anxiety?

Statins and antidepressants induce similar in vitro gene expression responses

Obesity, Quality of Sleep and Anxiety in Saudi Arabia

Contact Info

Product

Resources

About