The related factors of new HIV infection among older men in Sichuan, China: a case–control study

Yuan, Fengshun; Liu, Li; Su, Ling; Zeng, Yao; Liang, Shu

doi:10.1017/s0950268822001352

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…Preliminary studies show that the sex trade of elderly whoring clients in low-grade entertainment place was the main reason for the network transmission. 34 In recent years, the reported number and composition ratio of elderly male HIV-infected patients in Sichuan province have increased year by year, 35 suggesting that more attention should be paid to the surveillance of elderly men and sex workers in this area in the future, and the intervention of spouses of HIV-infected patients should be strengthened to reduce transmission within the family.…”

Section: Discussionmentioning

confidence: 99%

Exploring and Predicting the Drivers of Ongoing HIV-1 Transmission in Guangyuan, Sichuan

Zhang,

Jiang,

Xiang

et al. 2023

IDR

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Purpose Guangyuan was selected as the first pilot city of molecular transmission network in Sichuan Province to implement dynamic monitoring. This study aim to insight the characteristics of HIV-1 molecular epidemiology and explore the influencing factors of transmission dynamics. Furthermore, it predict the driving factors of network expansion by established a transmission risk prediction model. Patients and Methods A longitudinal cohort study was conducted to obtain a total of 1434 plasma samples from newly diagnosed HIV-infected patients from 2010 to June 2022. Phylogenetic relationship and cluster analysis were performed using HIV-1 polymerase ( pol ) gene sequences to study the risk factors of clustering. We applied Logistic ML algorithms to establish a transmission risk prediction model, and model performance was checked using 10-fold cross-validation in the training set and receiver operating characteristic (ROC) curve analysis. Results A total of 1360 pol sequences linked demographics obtained in this study cover approximately 94.8% of newly notified infections from 2010 to June 2022. The major epidemic genotypes were CRF07_BC, CRF01_AE, CRF08_BC and B subtypes, accounting for 93.82% of all. The differences of some clinical and demographic factors (eg, age, marital status) were statistically significant ( P <0.05). We identified 136 clusters containing 654 HIV-1 pol sequences and observed that some characteristics (eg, over 50 years, married) were more likely to associated to the clusters ( P <0.05). The predictive model showed excellent predictive ability to forecast cluster growth. Conclusion The epidemic genotypes were relatively complex and diverse in Guangyuan. There was a potential transmission association caused widely spread in local area after the new strains entering. The transmission risk prediction model showed excellent predictive ability to forecast cluster growth which can predict the risk factors causing clusters expansion and provide a guidance for precise intervention strategies.

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Section: Discussionmentioning

confidence: 99%

Exploring and Predicting the Drivers of Ongoing HIV-1 Transmission in Guangyuan, Sichuan

Zhang,

Jiang,

Xiang

et al. 2023

IDR

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“…57 Among older men, the primary mode of heterosexual transmission is commercial heterosexual contact due to sex needs, single, widowhood, and a stable financial situation. [61][62][63] Besides, works 64 on HIV-1 molecular epidemiology showed that commercial heterosexuality caused an aggregated HIV epidemic in this region, and HIV-1 genetic transmission networks 65,66 suggested that there was more likely regional transmission in these areas. In summary, HIV prevention approaches in these areas may require joint interventions, both inside and outside (eg, information exchange for better launching joint interventions and collaborating with each other).…”

mentioning

confidence: 99%

The Update of HIV-1 Prevalence and Incidence and Spatio-Temporal Analyses of HIV Recent Infection Among Four Sub-Groups in Sichuan, China During Surveillance Period Between 2016 and 2022

Yang,

Li,

et al. 2023

IDR

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Background Sichuan Province has gradually become a hot-spot for HIV/AIDS. Little is known about the HIV-1 incidence and prevalence among four sub-groups since 2015. Meanwhile, the distributions of hot-spot areas related to recent infection cases that indicate current transmission among the four subgroups are also rare. Objective The main purpose of this study was to assess the HIV-1 prevalence and incidence and to visualize the distributions of hot-spot areas of current transmission among four subgroups (people who inject drugs, male STD clinic attendees, female sex workers and men who had sex with men) during the surveillance period in Sichuan province between 2016 and 2022. Results Of the 267,617 individuals, 2158 HIV-positive samples were tested with Lag-Avidity EIA, among which 493 samples were identified as recent infections. Among people who inject drugs (PWID), both HIV-1 prevalence (from 1.41% to 0.34%) and incidence (from 0.03% to 0.140%) showed a significant decreasing trend. Among men who had sex with men (MSM), female sex workers (FSWs), and male STD clinic attendees, HIV-1 prevalence indicated significant decreasing trends, whereas HIV-1 incidence showed no significant changes. Spatial analysis demonstrated the formation of hot-spots and clusters of current transmissions sharing regional differences, mainly concentrated in the southeast, and most of these were consecutive hot-spots. Conclusion The prevention and control were efficacious and persistent. However, among the other three subgroups, there is a need for a regional cooperative in prevention and control approaches and collaborative research in many aspects.

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Global, regional, and national burden of HIV and other sexually transmitted infections in older adults aged 60–89 years from 1990 to 2019: results from the Global Burden of Disease Study 2019

Fu,

Tian,

Wang

et al. 2024

The Lancet Healthy Longevity

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The related factors of new HIV infection among older men in Sichuan, China: a case–control study

Cited by 4 publications

References 37 publications

Exploring and Predicting the Drivers of Ongoing HIV-1 Transmission in Guangyuan, Sichuan

Exploring and Predicting the Drivers of Ongoing HIV-1 Transmission in Guangyuan, Sichuan

The Update of HIV-1 Prevalence and Incidence and Spatio-Temporal Analyses of HIV Recent Infection Among Four Sub-Groups in Sichuan, China During Surveillance Period Between 2016 and 2022

Global, regional, and national burden of HIV and other sexually transmitted infections in older adults aged 60–89 years from 1990 to 2019: results from the Global Burden of Disease Study 2019

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