The regulatory role of neurotensin on the hypothalamic–anterior pituitary axons: Emphasis on the control of thyroid-related functions

Stolakis, Vasileios; Kalafatakis, Konstantinos; Botis, John; Ζάρρος, Απόστολος; Liapi, Charis

doi:10.1016/j.npep.2009.09.005

Cited by 21 publications

(11 citation statements)

References 81 publications

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“…The pattern of changes we measured in D2 mRNA was intriguing but didn't reach statistical significance; it does however warrant future investigation. Also, our list of candidates was certainly not exhaustive; other neuropeptides and neurosystems have been shown to impact the HPT axis (Lechan and Fekete, 2006, Nillni, 2010, Stolakis et al, 2010). TRH activity could also be decreased without accompanying changes in mRNA levels; for example changes in processing of the TRH molecule may alter its bioactivity (Perello et al, 2006) or the TRH specific peptidase PP II (Heuer et al, 1998) located within the tanycytes in the medial-basal hypothalamus (Sanchez et al, 2009) may also alter TRH bioactivity.…”

Section: Discussionmentioning

confidence: 99%

Thyroid hormone regulation by stress and behavioral differences in adult male rats

Helmreich¹,

Tylee²

2011

Hormones and Behavior

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Thyroid hormones are essential regulators of growth, development and normal bodily function and their release is coordinated by the hypothalamic-pituitary-thyroid (HPT) axis. While the HPT axis has been established as an acutely stress-responsive neuroendocrine system, relatively little is known about the mechanisms of its stress-regulation. The present study examined acute stress-induced changes in peripheral hormone levels [triiodothyronine (T3); thyroxine (T4), thyroid-stimulating hormone (TSH), reverse triiodothyronine (rT3)] and central mRNA levels of regulators of the HPT axis [thyrotropin-releasing hormone (TRH), somatostatin (SST), type II deiodinase (D2)] in response to an inescapable tail-shock, a rodent model of stress. Additionally, we examined whether individual differences in spontaneous exploratory behavior in an open field test predicted basal levels of TH or differential susceptibility to the effects of stress. The stress condition was associated with decreases in peripheral T3, T4 and TSH, but not rT3, when compared with controls. No changes were observed in TRH or SST mRNA levels, but there was a trend suggesting stress-related increases in D2 mRNA. We also found that an animal's exploratory behavior in an unfamiliar open field arena was positively related to peripheral thyroid hormone levels and predicted the magnitude of stress-induced changes. In conclusion, we found suggestive evidence for stress-induced decrease in central drive HPT axis, but the central mechanisms of its stress-regulation remain to be elucidated. Additionally, we found that individual differences in animals' exploratory behavior were correlated with peripheral TH levels.

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Section: Discussionmentioning

confidence: 99%

Thyroid hormone regulation by stress and behavioral differences in adult male rats

Helmreich¹,

Tylee²

2011

Hormones and Behavior

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“…NT is expressed in many tissues both centrally and peripherally. In the CNS, NT is widely expressed at high levels in the amygdala, hypothalamus, SN and VTA, and at lower levels in areas such as the hippocampus, cortex and striatum (Manberg et al, 1982; Stolakis et al, 2010; Boules et al, 2013). Thus, NT is found within corticostriatal-limbic circuitry where it acts as a neurotransmitter and neuromodulator (Binder et al, 2001a; Ferraro et al, 2008; Petkova-Kirova et al, 2008a,b).…”

Section: Neurotensinmentioning

confidence: 99%

“…Centrally, NT has a wide range of actions. NT plays a role in opioid-independent antinociception (Kleczkowska and Lipkowski, 2013), hypothermia (Bissette et al, 1976), blood pressure (Sumners et al, 1982), anterior pituitary hormone secretion (Rostene and Alexander, 1997; Stolakis et al, 2010), food intake (Cooke et al, 2009), and sleep (Fitzpatrick et al, 2012). NT also possesses antipsychotic-like effects, which are largely attributed to NT-mediated regulation of dopaminergic signaling (Binder et al, 2001b; Kinkead and Nemeroff, 2004, 2006; Vadnie et al, 2014).…”

Section: Neurotensinmentioning

confidence: 99%

Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders

et al. 2014

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Peptides synthesized in endocrine cells in the gastrointestinal tract and neurons are traditionally considered regulators of metabolism, energy intake, and appetite. However, recent work has demonstrated that many of these peptides act on corticostriatal-limbic circuitry and, in turn, regulate addictive behaviors. Given that alcohol is a source of energy and an addictive substance, it is not surprising that increasing evidence supports a role for gut-brain peptides specifically in alcohol use disorders (AUD). In this review, we discuss the effects of several gut-brain peptides on alcohol-related behaviors and the potential mechanisms by which these gut-brain peptides may interfere with alcohol-induced changes in corticostriatal-limbic circuitry. This review provides a summary of current knowledge on gut-brain peptides focusing on five peptides: neurotensin, glucagon-like peptide 1, ghrelin, substance P, and neuropeptide Y. Our review will be helpful to develop novel therapeutic targets for AUD.

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“…The role of neurotensin in the hypothalamic-pituitary axis has been extensively reviewed by Rostene and Alexander [14], and a recent review by Stolakis et al [15] emphasized the involvement of neurotensin in centrally controlled thyroid-related functions. Dungan Lemko et al [16] recently investigated the role of neurotensin in the gonadotropin-releasing hormone (GnRH)-induced luteinizing hormone (LH) surge required for ovulation, in which the presence of estrogen-receptors on neurotensinergic inputs to the hypothalamus has been suggested as a link in the positive feedback of estradiol (E2) on GnRH release [17,18].…”

Section: Neurotensin and Other Neural Pathwaysmentioning

confidence: 99%

The role of neurotensin in physiologic and pathologic processes

Mustain

Rychahou

Evers

2011

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

115

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The review highlights the wide array of biological processes in which neurotensin has a role, and summarizes the most recent advances in various fields of neurotensin research. The knowledge gained through this research has led to the development of first-in-class drugs for the treatment of various medical conditions, and it is clear that in the coming years some of these agents will be ready to move from the bench to the bedside in clinical trials.

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The regulatory role of neurotensin on the hypothalamic–anterior pituitary axons: Emphasis on the control of thyroid-related functions

Cited by 21 publications

References 81 publications

Thyroid hormone regulation by stress and behavioral differences in adult male rats

Thyroid hormone regulation by stress and behavioral differences in adult male rats

Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders

The role of neurotensin in physiologic and pathologic processes

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