The role of neurotensin in physiologic and pathologic processes

Mustain, W. Conan; Rychahou, Piotr G.; Evers, B. Mark

doi:10.1097/med.0b013e3283419052

Cited by 114 publications

(95 citation statements)

References 86 publications

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“…NT, a brain peptide involved in inflammation [118], stimulates rodent MCs through NTR [119,120] to secrete histamine and elevates histamine plasma levels [121]. NT administration increases vascular permeability in isolated rat skin [122] and in skin blisters in a MC-dependent manner [123].…”

Section: Stress Crh and Immune Cellsmentioning

confidence: 99%

Neuroendocrinology of the skin

Theoharides

Stewart

Taracanova

et al. 2016

Rev Endocr Metab Disord

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The skin is considered the mirror of the soul and is affected by neurohormonal triggers, especially stress. Hair follicles, keratinocytes, mast cells, melanocytes, and sebocytes all express sex and stress hormones implicating them in a local "hypothalamic-pituitary-adrenal axis." In particular, the peptides corticotropin-releasing hormone (CRH) and neurotensin (NT) have synergistic action stimulating mast cells and are uniquely elevated in the serum of patients with skin diseases exacerbated by stress. Addressing the neurohormonal regulation of skin function could lead to new targets for effective treatment of inflammatory skin diseases.

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Section: Stress Crh and Immune Cellsmentioning

confidence: 99%

Neuroendocrinology of the skin

Theoharides

Stewart

Taracanova

et al. 2016

Rev Endocr Metab Disord

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“…It has been established that ENK is related to morphine-and http://dx.doi.org/10.1016/j.neulet.2014. 11.008 0304-3940/© 2014 Elsevier Ireland Ltd. All rights reserved. (For interpretation of the reference to color in the text, the reader is referred to the web version of this article.)…”

Section: Introductionmentioning

confidence: 96%

“…Arrows indicate the co-localization of VGluT2 and NT or ENK. Bar 6 m. stimulation-produced analgesia, and NT is involved in the modulation of pain transmission in the MDH [9][10][11]. Though, NT or ENK ergic terminals in the MDH have been shown to be involved in excitatory synaptic transmission to modulate nociceptive information, there is lack of direct morphological evidence.…”

Section: Introductionmentioning

confidence: 97%

The coexistence of VGluT2 and neurotensin or leu-enkephalin in the medullary dorsal horn: A confocal and electron microscopic immunohistochemical study in the rat

Liu

et al. 2015

Neuroscience Letters

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“…The actions of neurotensin are mediated by three known neurotensin receptors: NTS1, NTS2, and NTS3 (for review, see Vincent et al 1999). There is abundant evidence that neurotensin interacts with the DA system (for review, see Binder et al 2001) and dysregulation of these interactions has been proposed to be involved in pathol-ogies such as schizophrenia, drug abuse, and Parkinson's disease (Binder et al 2001;Mustain et al 2011;St-Gelais et al 2006;Tanganelli et al 2012). Fibers containing neurotensin heavily innervate midbrain DA neurons (Hokfelt et al 1984;Woulfe and Beaudet 1989), and DA neurons of the VTA and SNc express neurotensin receptors, primarily the NTS1 receptor (Binder et al 2001;Fassio et al 2000;Lepee-Lorgeoux et al 1999;Nicot et al 1995;Palacios and Kuhar 1981;Szigethy and Beaudet 1989).…”

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confidence: 99%

Neurotensin inhibits both dopamine- and GABA-mediated inhibition of ventral tegmental area dopamine neurons

Stuhrman

Roseberry

2015

Journal of Neurophysiology

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Stuhrman K, Roseberry AG. Neurotensin inhibits both dopamine-and GABA-mediated inhibition of ventral tegmental area dopamine neurons. J Neurophysiol 114: 1734 -1745, 2015. First published July 15, 2015 doi:10.1152/jn.00279.2015-Dopamine is an essential neurotransmitter that plays an important role in a number of different physiological processes and disorders. There is substantial evidence that the neuropeptide neurotensin interacts with the mesolimbic dopamine system and can regulate dopamine neuron activity. In these studies we have used whole cell patch-clamp electrophysiology in brain slices from mice to examine how neurotensin regulates dopamine neuron activity by examining the effect of neurotensin on the inhibitory postsynaptic current generated by somatodendritic dopamine release (D2R IPSC) in ventral tegmental area (VTA) dopamine neurons. Neurotensin inhibited the D2R IPSC and activated an inward current in VTA dopamine neurons that appeared to be at least partially mediated by activation of a transient receptor potential C-type channel. Neither the inward current nor the inhibition of the D2R IPSC was affected by blocking PKC or calcium release from intracellular stores, and the inhibition of the D2R IPSC was greater with neurotensin compared with activation of other G q -coupled receptors. Interestingly, the effects of neurotensin were not specific to D2R signaling as neurotensin also inhibited GABA B inhibitory postsynaptic currents in VTA dopamine neurons. Finally, the effects of neurotensin were significantly larger when intracellular Ca 2ϩ was strongly buffered, suggesting that reduced intracellular calcium facilitates these effects. Overall these results suggest that neurotensin may inhibit the D2R and GABA B IPSCs downstream of receptor activation, potentially through regulation of G protein-coupled inwardly rectifying potassium channels. These studies provide an important advance in our understanding of dopamine neuron activity and how it is controlled by neurotensin.

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The role of neurotensin in physiologic and pathologic processes

Cited by 114 publications

References 86 publications

Neuroendocrinology of the skin

Neuroendocrinology of the skin

The coexistence of VGluT2 and neurotensin or leu-enkephalin in the medullary dorsal horn: A confocal and electron microscopic immunohistochemical study in the rat

Neurotensin inhibits both dopamine- and GABA-mediated inhibition of ventral tegmental area dopamine neurons

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