The regulative effect of galanin family members on link of energy metabolism and reproduction

Fang, Penghua; He, Ben; Shi, Mingyi; Kong, Guimei; Dong, Xiaoyun; Zhu, Yichao; Bo, Ping; Zhang, Zhenwen

doi:10.1016/j.peptides.2015.07.007

Cited by 25 publications

(25 citation statements)

References 183 publications

(263 reference statements)

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“…but such relationship was not found in the present study, possibly because our subjects were not diabetic. Throughout different studies in animal and human models, the type 2 diabetes mellitus phenotype has been characterized by obesity, hyperglycemia, hyperinsulinemia, insulin resistance, elevated GAL levels and a reduced activity of the GAL receptor29. GAL increases fat deposition and contributes to the development of obesity by favoring glucose utilization over fat utilization1.…”

Section: Discussionmentioning

confidence: 99%

Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test

Sandoval-Alzate

Agudelo-Zapata

Clavijo

et al. 2016

Sci Rep

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Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m2) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m2). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p < 0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA–IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120 minutes during the OGTT is the most predictive variable for serum GAL levels (p < 0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.

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Section: Discussionmentioning

confidence: 99%

Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test

Sandoval-Alzate

Agudelo-Zapata

Clavijo

et al. 2016

Sci Rep

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“…KISS peptides in humans are required for puberty and maintenance of normal reproductive function but also regulate food intake and fat mass production (d'Anglemont de Tassigny, 2010; Wahab, 2013;Brown, 2008). Galanin has similar functions to KISS peptides and is co-expressed with GnRH and changes in energy intake modify its levels in serum and the hypothalamus (Fang, 2015;Lang, 2007). In humans, a single KISSR and three GALR (GALR1, GALR2 and GALR3) genes exist but in the slow evolving genomes of the spotted gar (Lepisosteus oculatus) a ray-finned fish (Amores, 2011), four KISSRs and four GALRs exist and in the cartilaginous elephant shark (Callorhinchus milii) (Venkatesh, 2014) three KISSRs and five GALRs are predicted, suggesting that members of this family expanded early in the vertebrate radiation but subsequently gene deletion occurred in some lineages (Felix, 2015;Kim, 2014;Pasquier, 2012).…”

Section: The Allatostatin-type a Kisspeptin And Galanin Systemsmentioning

confidence: 99%

Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function

et al. 2016

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Allatostatin-type A (AST-A), kisspeptin (KISS) and galanin (GAL) G-protein coupled receptor (GPCR) systems share a common ancestral origin in arthropods and the vertebrates where they regulate metabolism and reproduction. The molluscs are the second most diverse phylum in the animal kingdom, they occupy an important phylogenetic position, and their genome is more similar to deuterostomes than the arthropods and nematodes and thus they are good models for studies of gene family evolution and function. This mini-review intends to extend the current knowledge about AST-A, KISS and GAL GPCR system evolution and their putative function in the mollusc mantle. Comparative evolutionary analysis of the target GPCR systems was established by identifying homologues in genomes and tissue transcriptome datasets available for molluscs and comparing them to those of other metazoan systems. Studies in arthropods have revealed the existence of the AST-A system but the loss of homologues of the KISS and GAL systems. Homologues of the insect AST-AR and vertebrate KISSR genes were found in molluscs but putative GALR genes were absent. Receptor gene number suggested that members of this family have suffered lineage specific evolution during the molluscan radiation. In molluscs, orthologues of the insect AST-A peptides were not identified but buccalin peptides that are structurally related were identified and are putative receptor agonists. The identification of AST-AR and KISSR genes in molluscs strengthens the hypotheses that in metazoans members of the AST-AR subfamily share evolutionary proximity with KISSRs. The variable number of receptors and large repertoire of buccalin peptides may be indicative of the functional diversity of the AST-AR/KISSR systems in molluscs. The identification of AST-A and KISS receptors and ligands in the mantle transcriptome indicates that in molluscs they may have acquired a novel function and may play a role in shell development or sensory detection in the mantle.

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“…Subsequently, the histological study of testes and ovaries showed that galanin had no pronounced negative effects on gonadal tissues of rabbits. Several studies revealed that galanin was a remarkable neuromodulator of reproductive hormones like testosterone, estrogen and progesterone secretion through GnRHstimulation in mammals including human being [14] . These findings were compatible with those of prevailing study suggesting that galanin may be a potent modulator of reproduction.…”

Section: Discussionmentioning

confidence: 99%

“…Galanin primarily serves as a neurotransmitter for the transmission of impulses in the central as well as peripheral nervous system [11][12][13]. Recent studies has demonstrated that galanin (GAL) is involved in certain other processes like reproduction, gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), LH-releasing hormone (LHRH) [14], uterine contraction regulation [15], regulation of estrogen [16] [36]. Although galanin performs various functions, however, the objective of this work was to evaluate its effect on reproductive hormones and histopathology of reproductive organs of rabbit.…”

mentioning

confidence: 99%

Histopathological effects of galanin on reproductive hormones and reproductive organs of rabbit (Oryctolagus cuniculus)

Shah

Iqbal²,

Hussain³

et al. 2019

PAB

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The regulative effect of galanin family members on link of energy metabolism and reproduction

Cited by 25 publications

References 183 publications

Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test

Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test

Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function

Histopathological effects of galanin on reproductive hormones and reproductive organs of rabbit (Oryctolagus cuniculus)

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