The Regulation of Lipid Metabolism by Targeting Opioid
Receptors in Nonalcoholic Fatty Liver Disease

Chung, Hsien-Hui

doi:10.17554/j.issn.2224-3992.2017.06.683

Cited by 2 publications

(2 citation statements)

References 44 publications

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“…(2012) showed that mitragynine activates opioid receptors [ 29 ]. Opioid receptors have a role in lipid and energy metabolism control [ 30 ] and positive influence on glucose metabolism regulation [ 31 ]. Therefore, the effect of kratom on metabolic syndrome is possibly due to effects of mitragynine on COX-2 expression and opioid receptors.…”

Section: Discussionmentioning

confidence: 99%

Association between kratom (Mitragyna speciosa) use and metabolic syndrome

La-up

Wongrit

Chaichan³

et al. 2022

Heliyon

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Section: Discussionmentioning

confidence: 99%

Association between kratom (Mitragyna speciosa) use and metabolic syndrome

La-up

Wongrit

Chaichan³

et al. 2022

Heliyon

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“…The protective effect of TSF on hepatic steatosis was verified in HFD-fed and MCDD-fed mice, two frequently used dietary models for NAFLD (Chung, 2017). HFD-fed mice form simple steatosis in the presence of lipid surplus but do not tend to progress in NASH spontaneously (Wang et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway

Wang

Zhao

et al. 2019

Front. Physiol.

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Tangshen formula (TSF), a formula of Chinese herbal medicine, improves lipid metabolism in humans and animals with diabetic kidney disease. However, the effect and mechanism of TSF on nonalcoholic fatty liver disease (NAFLD) remain unclear. The activation of autophagy appears to be a potential mechanism for improving NAFLD. In the present study, we examined the therapeutic effect of TSF on hepatic steatosis and sought to explore whether its effect is related to activating autophagy. Here, we showed that TSF treatment significantly attenuated hepatic steatosis in both high-fat diet (HFD) and methionine choline-deficient diet (MCDD)-fed mice. Meanwhile, TSF reduced lipid accumulation in palmitate (PA)-stimulated HepG2 cells and primary mouse hepatocytes. Furthermore, TSF increased Sirtuin 1 (SIRT1) expression and promoted autophagy activation in vivo . TSF also improved PA-induced suppression of both SIRT1 expression and SIRT1-dependent autophagy, thereby alleviating intracellular lipid accumulation in vitro . In addition, TSF increased SIRT1 expression and induced autophagy in an adenosine monophosphate-activated protein kinase (AMPK)-dependent manner. Moreover, SIRT1 knockdown abolished the autophagy-inducing and lipid-lowering effects of TSF. In conclusion, TSF improved lipid accumulation and hepatic steatosis by inducing the AMPK/SIRT1 pathway-mediated autophagy.

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The Regulation of Lipid Metabolism by Targeting Opioid Receptors in Nonalcoholic Fatty Liver Disease

Cited by 2 publications

References 44 publications

Association between kratom (Mitragyna speciosa) use and metabolic syndrome

Association between kratom (Mitragyna speciosa) use and metabolic syndrome

Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway

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