The Regulation of Host Intestinal Microbiota by Polyphenols in the Development and Prevention of Chronic Kidney Disease

Bao, Naren two ya; Chen, Fangjie; Dai, De‐Zai

doi:10.3389/fimmu.2019.02981

Cited by 32 publications

(17 citation statements)

References 119 publications

(130 reference statements)

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“…As one of the most abundant polyphenols in human diet, chlorogenic acid (CGA) is mainly from coffee, fruits and vegetables, and is also an important bioactive component in some medicine (Upadhyay and Mohan Rao, 2013). Polyphenols including CGA can inhibit pathogenic bacteria and help regulate intestinal microorganisms (Bao et al, 2019). Studies have shown that CGA has anti-oxidative, anti-inflammatory and antibacterial effects, and improves immune regulation (Tosovic et al, 2017;Zhang et al, 2018;Wang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway

Tan

Fang

et al. 2020

Front. Cell Dev. Biol.

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Background: Salmonella typhimurium (ST) causes several intestinal diseases. Polyphenols including chlorogenic acid (CGA) inhibit pathogenesis. Objective: This study aimed to investigate the mechanisms of CGA in ST infection. Methods: The intestinal pathological changes and survival rate of ST-infected mice were measured to verify the protection of CGA on ST infection. The antibacterial effects of CGA in vitro on the invasion to intestinal epithelial cells and autophagy was evaluated. The relationships among GAS5, miR-23a, and PTEN were verified. Expression of inflammation-and autophagy-related proteins was detected. Results: CGA treatment alleviated pathological damage, improved the secretion disturbance of intestinal cytokines caused by ST infection, and reduced the mortality of mice. Intestinal GAS5 was upregulated after CGA treatment. LncRNA GAS5 competitively bound to miR-23a to upregulate PTEN and inhibit the p38 MAPK pathway. CGA regulated the p38 MAPK pathway through lncRNA GAS5/miR-23a/PTEN axis to promote autophagy in ST infection. The functional rescue experiments of miR-23a and PTEN further identified these effects. Conclusion: CGA promotes autophagy and inhibits ST infection through the GAS5/miR-23a/PTEN axis and the p38 MAPK pathway.

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Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway

Tan

Fang

et al. 2020

Front. Cell Dev. Biol.

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“…According to the latest global kidney disease health report released by the World Kidney Conference in 2021, 1 out of 10 people in the world suffers from kidney disease [25]. In recent years, more and more evidence has shown that there are disorders of intestinal ora and impaired intestinal barrier function in patients with chronic kidney disease [26][27][28][29][30]. Therefore, more and more scienti c experiments are investigated the mechanism of the intestinal-renal axis in CKD, hoping to delay its progress by regulating the intestinal ora.…”

Section: Discussionmentioning

confidence: 99%

Lanthanum Hydroxide Protects Kidney Through Gut-Metabolite-Kidney Axis in a Rat Model of CKD

Gao

Wang

Sun

et al. 2021

Preprint

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Background: Recent evidence suggests alterations in the gut-kidney axis may drive chronic kidney disease (CKD). Results: In the present study, we observed that administration of adenine to rats induced CKD, gut microbial dysbiosis, kidney pathology, and amino acid metabolism. In this model of CKD hyperphosphatemia, lanthanum hydroxide improved kidney function in CKD rats by restoring gut microbial homeostasis, thereby increasing urine ammonium metabolism. These findings demonstrated that lanthanum hydroxide improves kidney function in a CKD model in mice by restoring homeostasis of the gut-metabolite-kidney axis, which alleviated an amino acid imbalance. Lanthanum hydroxide thus shows therapeutic potential for patients with CKD, through reshaping the composition of gut microbiota.Conclusions: Lanthanum hydroxide plays a kidney protective role through the gut-metabolite-kidney axis in a rat model of chronic kidney disease caused by adenine.

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“…Evidence shows that various polyphenols, including resveratrol, can promote gut microbiota by inhibiting various bacterial pathogens, namely E. coli and Salmonella , and thereby can improve inflammation and mitigate kidney damage [ 243 ]. Oral administration of resveratrol ameliorates gut dysbiosis in db/db mice by increasing the intestinal bacterial population, such as Bacteroides, Alistipes, Rikenella, Odoribacter, Parabacteroides, and Alloprevotella .…”

Section: Role Of Resveratrol On Gut Dysbiosis and Associated Ckd Pathobiologymentioning

confidence: 99%

Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging

Uddin

Farjana²,

Moni³

et al. 2021

IJMS

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Aging is an unavoidable part of life. The more aged we become, the more susceptible we become to various complications and damages to the vital organs, including the kidneys. The existing drugs for kidney diseases are mostly of synthetic origins; thus, natural compounds with minimal side-effects have attracted growing interest from the scientific community and pharmaceutical companies. A literature search was carried out to collect published research information on the effects of resveratrol on kidney aging. Recently, resveratrol has emerged as a potential anti-aging agent. This versatile polyphenol exerts its anti-aging effects by intervening in various pathologies and multi-signaling systems, including sirtuin type 1, AMP-activated protein kinase, and nuclear factor-κB. Researchers are trying to figure out the detailed mechanisms and possible resveratrol-mediated interventions in divergent pathways at the molecular level. This review highlights (i) the causative factors implicated in kidney aging and the therapeutic aspects of resveratrol, and (ii) the effectiveness of resveratrol in delaying the aging process of the kidney while minimizing all possible side effects.

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The Regulation of Host Intestinal Microbiota by Polyphenols in the Development and Prevention of Chronic Kidney Disease

Cited by 32 publications

References 119 publications

Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway

Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway

Lanthanum Hydroxide Protects Kidney Through Gut-Metabolite-Kidney Axis in a Rat Model of CKD

Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging

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