1980
DOI: 10.1007/978-3-540-38267-6_26
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The Regulation of Differentiation in Murine Virus-Induced Erythroleukemic Cells

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Cited by 20 publications
(18 citation statements)
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“…
(Friend, 1978). FLC clones maintained in vitro for several years are not very tumorigenic when first injected intraperitoneally (i.p.)
…”
mentioning
confidence: 99%
“…
(Friend, 1978). FLC clones maintained in vitro for several years are not very tumorigenic when first injected intraperitoneally (i.p.)
…”
mentioning
confidence: 99%
“…Friend virus-transformed murine erythroleukemic cells (FELC) have been extensively studied [12,13]. They grow in culture as undifferentiated proerythroblasts but can be induced to differentiate along the erythroid pathway to orthochromatic normoblasts by various chemicals including dimethylsulfoxide (DMSO) [13].…”
Section: Introductionmentioning
confidence: 99%
“…DMSO is known to alter cell membrane permeability and trigger differentiation in cer tain cell lines. For example, Friend leukemia cells are nucleated erythroid precursors which, when treated with DMSO, differentiate [8] and also produce a 2-fold greater amount of Friend leukemia virus-specific RNA in the cytoplasm [9,10]. This finding suggests that differentiation produces a cell which is more tolerant of virus production.…”
mentioning
confidence: 54%