The Regulating Function of Heterotrimeric G Proteins in the Immune System

Wang, Yantang; Li, Yan; Shi, Guixiu

doi:10.1007/s00005-013-0230-5

Cited by 25 publications

(22 citation statements)

References 86 publications

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“…G proteins act as molecular switches to control downstream effector molecules including chemokines and chemokine receptors 33 . In immune cells, G proteins impact signal transduction and affect survival, proliferation, differentiation and cell migration and recent evidence suggests non-canonical GPCR signalling in immune cells 33,55 .…”

Section: Discussionmentioning

confidence: 99%

Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination

Hasso-Agopsowicz

Scriba

Hanekom

et al. 2018

Sci Rep

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Bacillus Calmette–Guérin (BCG) is the only licensed vaccine for tuberculosis (TB) and induces highly variable protection against pulmonary disease in different countries. We hypothesised that DNA methylation is one of the molecular mechanisms driving variability in BCG-induced immune responses. DNA methylation in peripheral blood mononuclear cells (PBMC) from BCG vaccinated infants was measured and comparisons made between low and high BCG-specific cytokine responders. We found 318 genes and 67 pathways with distinct patterns of DNA methylation, including immune pathways, e.g. for T cell activation, that are known to directly affect immune responses. We also highlight signalling pathways that could indirectly affect the BCG-induced immune response: potassium and calcium channel, muscarinic acetylcholine receptor, G Protein coupled receptor (GPCR), glutamate signalling and WNT pathways. This study suggests that in addition to immune pathways, cellular processes drive vaccine-induced immune responses. Our results highlight mechanisms that require consideration when designing new TB vaccines.

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Section: Discussionmentioning

confidence: 99%

Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination

Hasso-Agopsowicz

Scriba

Hanekom

et al. 2018

Sci Rep

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“…Heterotrimeric G proteins also play critical roles in the mammalian immune system (reviewed in ). Most of the G protein subunits are abundantly expressed on the surface of immune cells and they are required for the development, proliferation, and survival of lymphocytes.…”

Section: G Proteins Play Diverse Roles In Immune Responsesmentioning

confidence: 99%

A Pseudomonas aeruginosa‐secreted protease modulates host intrinsic immune responses, but how?

Cheng

2016

BioEssays

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Recently, we found that the Pseudomonas aeruginosa type II secreted protease IV functions as a unique Arabidopsis innate immunity elicitor. The protease IV-activated pathway involves G protein signaling and raises the question of how protease elicitation leads to the activation of G protein-mediated signaling, because plants do not appear to have metazoan-like G protein-coupled receptors. Importantly, our data suggest that Arabidopsis has evolved a mechanism to detect the proteolytic activity of a pathogen-encoded protease, supporting the host-pathogen arms race model. In the case of opportunistic multi-host pathogens like P. aeruginosa, however, it is not plausible that P. aeruginosa is simultaneously co-evolving in a gene-for-gene manner with all of its potential hosts, which include plants, nematodes, insects, and mammals. This prompts us to ask what is the driving force for co-evolution of defense response in Arabidopsis and pathogenesis of P. aeruginosa, which might not have been subject to iterative cycles of evolutionary selections.

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“…The heterotrimeric G-proteins consist of a α -subunit that binds and hydrolyses GTP as well as a β - and a γ -subunit that form an undissociable complex. Based on the types of their α subunits, G proteins can be grouped into four subfamilies, they are G α i, G α s, G α q/11, and G12/13, each subfamily contains several members of G proteins [78]. …”

Section: Signaling Pathways Involved In Chemokine Receptor Signalingmentioning

confidence: 99%

Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration

Liu

Shi

2014

BioMed Research International

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Dendritic cells (DCs) are highly efficient antigen-presenting cells. The migratory properties of DCs give them the capacity to be a sentinel of the body and the vital role in the induction and regulation of adaptive immune responses. Therefore, it is important to understand the mechanisms in control of migration of DCs to lymphoid and nonlymphoid tissues. This may provide us novel insight into the clinical treatment of diseases such as autoimmune disease, infectious disease, and tumor. The chemotactic G protein-coupled receptors (GPCR) play a vital role in control of DCs migration. Here, we reviewed the recent advances regarding the role of GPCR in control of migration of subsets of DCs, with a focus on the chemokine receptors. Understanding subsets of DCs migration could provide a rational basis for the design of novel therapies in various clinical conditions.

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The Regulating Function of Heterotrimeric G Proteins in the Immune System

Cited by 25 publications

References 86 publications

Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination

Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination

A Pseudomonas aeruginosa‐secreted protease modulates host intrinsic immune responses, but how?

Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration

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