The regular use of an emollient improves symptoms of atopic dermatitis in children: a randomized controlled study

Tiplica, G.S.; Boralévi, F.; Konno, Pille; Malinauskienė, Laura; Kaszuba, Andrzej; Laurens, Claire; Saint-Aroman, Markéta; Delarue, Alain

doi:10.1111/jdv.14849

Cited by 30 publications

(28 citation statements)

References 24 publications

(41 reference statements)

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“…It was not powered to compare the effectiveness of the interventions, but eczema severity improved in all groups over a 12 week period 14. An open-label study1516 randomised 335 children aged 2-6 years with mild to moderate atopic dermatitis to Dexeryl (V0034CR) cream, Atopiclair cream, or no emollient: the proportion of patients with one or more flares and the number of flares was lower in both emollient groups, with Dexeryl cream seeming to perform better than Atopiclair cream.…”

Section: What Is the Evidence Of Uncertainty?mentioning

confidence: 99%

Which emollients are effective and acceptable for eczema in children?

Ridd

Roberts²,

Grindlay

et al. 2019

BMJ

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What you need to know • Although emollients alone can help reduce the symptoms of eczema and prevent flares, most people will need to use anti-inflammatory treatments such as topical corticosteroids of an appropriate strength and duration as well • Effectiveness and acceptability of emollients varies according to disease severity, body site, climate, container, and patient or carer preferences and beliefs • Based on current evidence, the "best" emollient is the one that the individual prefers after a period of testing

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Section: What Is the Evidence Of Uncertainty?mentioning

confidence: 99%

Which emollients are effective and acceptable for eczema in children?

Ridd

Roberts²,

Grindlay

et al. 2019

BMJ

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show abstract

“…In infants and children, the type of emollient used should be carefully chosen taking into account that urea and propylene glycol can cause irritant reactions and renal toxicity if they are absorbed systemically. regular use of emollients in children with mild to moderate aD reduces flares and corticosteroid consumption and, therefore, supports their use as a first-line treatment for these patients (13,14).…”

Section: Topical Therapies Cleansing and Bathingmentioning

confidence: 78%

Recommended strategies for atopic dermatitis management in Romania

Ţiplica¹,

Sălăvăstru²,

Szepietowski³

et al. 2019

Ro Med J.

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Recommended stRategies foR atopic deRmatitis management in Romaniaprof. george-sorin tiplica 1 , md, phd, prof. carmen maria salavastru 2 , md, phd, prof. Jacek c. szepietowski 3 , md, phd, prof. magdalena czarnecka-operacz 4 , md, phd, assist. prof. alina suru 2 , md, phd, assist. prof. ionela manole 1 , md, phd student ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease with a relapsing course that has a significant impact on the quality of life of both patients and their families. The pathogenesis of AD is due to a multitude of factors and can be associated with other allergy-related diseases, including asthma, food allergies or rhinitis. Treatment of AD aims to reduce duration, severity, and frequency of disease exacerbations. Understanding the maintenance of skin barrier integrity by continuing the use of basic therapy can prevent breaks. Patient and family education is important.

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“…However, our findings clearly demonstrate the beneficial effects of using the study product after only 1 week. A recent study analyzing the kinetics of the response to regular emollient use in children with mild-to-moderate atopic dermatitis also found that the effects of emollients at reducing xerosis and improving SCORAD were already visible after 1 week, and that the improvements were progressive with regular emollient use over a 12-week period [41]. Further studies are required to determine if regular use of our study product over a longer period would result in further improvements in symptoms and if the symptom relief can be sustained.…”

Section: Discussionmentioning

confidence: 96%

An Emollient Containing Aquaphilus dolomiae Extract is Effective in the Management of Xerosis and Pruritus: An International, Real-World Study

Deleuran

Georgescu

Jean‐Decoster

2020

Dermatol Ther (Heidelb)

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Introduction: Xerosis and pruritus are common manifestations of numerous dermatologic and systemic diseases. We evaluated the effectiveness of an emollient containing an Aquaphilus dolomiae extract (ADE-G1) for the management of pruritus and xerosis in patients of all age with a range of dermatologic and systemic diseases. Methods: This open-label, real-world study involved 5910 patients from 33 European, South American, Asian, and North and South African countries, who applied the product for 7 days twice daily to the face and body after the skin had been cleansed and dried. The physician assessed xerosis severity and patients assessed pruritus severity, the duration of itch, sleep quality, and the impact of their skin disease on their quality of life, using scales derived from the SCORing Atopic Dermatitis (SCORAD) index and questionnaires, at inclusion and after 7 days of use. Results: The 7-day care regimen resulted in 56% and 60% reductions in xerosis and pruritus severity, respectively, regardless of the underlying pathology (p \ 0.0001), with the largest decreases observed for patients with ichthyosis for xerosis and for patients post scabies treatment for pruritus. The mean sleep disturbance and mean total Dermatology Life Quality Index (DLQI) scores were also reduced by 58% and 60% (p \ 0.0001), respectively. The emollient was effective whether the product was used alone or in combination with topical or systemic treatments and was well tolerated. Conclusion: Our study shows that the 7-day regimen with the emollient was a universally effective treatment for pruritus and xerosis, regardless of the underlying pathology.

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The regular use of an emollient improves symptoms of atopic dermatitis in children: a randomized controlled study

Abstract: These results demonstrate that the regular use of emollients in children with mild-to-moderate AD reduces the severity of symptoms and, therefore, support their use as a first-line treatment for these patients.

Cited by 30 publications

References 24 publications

Which emollients are effective and acceptable for eczema in children?

Which emollients are effective and acceptable for eczema in children?

Recommended strategies for atopic dermatitis management in Romania

An Emollient Containing Aquaphilus dolomiae Extract is Effective in the Management of Xerosis and Pruritus: An International, Real-World Study

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