An Emollient Containing Aquaphilus dolomiae Extract is Effective in the Management of Xerosis and Pruritus: An International, Real-World Study

Abstract

Introduction: Xerosis and pruritus are common manifestations of numerous dermatologic and systemic diseases. We evaluated the effectiveness of an emollient containing an Aquaphilus dolomiae extract (ADE-G1) for the management of pruritus and xerosis in patients of all age with a range of dermatologic and systemic diseases. Methods: This open-label, real-world study involved 5910 patients from 33 European, South American, Asian, and North and South African countries, who applied the product for 7 days twice daily to the face and body after the skin had been cleansed and dried. The physician assessed xerosis severity and patients assessed pruritus severity, the duration of itch, sleep quality, and the impact of their skin disease on their quality of life, using scales derived from the SCORing Atopic Dermatitis (SCORAD) index and questionnaires, at inclusion and after 7 days of use. Results: The 7-day care regimen resulted in 56% and 60% reductions in xerosis and pruritus severity, respectively, regardless of the underlying pathology (p \ 0.0001), with the largest decreases observed for patients with ichthyosis for xerosis and for patients post scabies treatment for pruritus. The mean sleep disturbance and mean total Dermatology Life Quality Index (DLQI) scores were also reduced by 58% and 60% (p \ 0.0001), respectively. The emollient was effective whether the product was used alone or in combination with topical or systemic treatments and was well tolerated. Conclusion: Our study shows that the 7-day regimen with the emollient was a universally effective treatment for pruritus and xerosis, regardless of the underlying pathology.

Use of Dexpanthenol for Atopic Dermatitis—Benefits and Recommendations Based on Current Evidence

“…The active, non-medicated substances are active ingredients that do not qualify as topical drugs [ 66 ], which include saponins, flavonoids, vitamins such as riboflavin and niacin, and beneficial bacterial lysates. Some of these active ingredients were found to improve skin protection, relieve pruritis, exert an anti-inflammatory reaction, exhibit antioxidant properties, and provide biologically essential lipids and antimicrobial activities [ 91 , 92 , 93 ]. Dexpanthenol is approved as a cosmetic ingredient with established safety, and it has evidence-based potent skin-hydration and wound-healing effects [ 19 , 40 , 41 ].…”

Scabies itch: an update on neuroimmune interactions and novel targets

“…Accordingly, drugs which interact with the TRP channels (e.g. topical capsaicin, topical calcineurin inhibitors, topical camphor, topical menthol, topical strontium hydrogel formulation (Tri-Calm TM ) and botulinum toxin) [146][147][148][149][150][151] have been reported Pepducin 128,130,131 Doxycycline and minocycline 127,132 Polidocanol 1,134 Emollient containing Aquaphilus dolomiae (ADE-G1) extract 135,136 MRGPRX2 Novel MRGPRX2 targeting antagonists 137,138 Natural polyphenolic compounds (i.e. genistein, resveratrol) 139,140 Shikonin 141…”

“…1,134 An emollient containing Aquaphilus dolomiae (ADE-G1) extract has also been shown to work on scabies itch by inhibiting PAR-2. 135,136 MRGPRX2 (found on non-histaminergic neurons and mast cells) is another potential target of scabies itch. Two novel MRGPRX2 antagonists were found to block substance P-induced de novo synthesis of prostaglandin D 2 and p42/44 mitogenactivated protein kinase signal in human umbilical cord bloodderived mast cells.…”

Skin Microbiome and its Interplay with the Environment

“…This strain belongs to the family Neisseriaceae within the class Betaproteobacteria, and exhibits specific properties that are beneficial for the skin. A postbiotic, containing a biotechnological extract from this microorganism, was found to display immunomodulatory, anti-inflammatory, antipruritic and tolerogenic activities in pharmacological models of atopic dermatitis, and thus has been incorporated into a skin care emollient [ 13 – 16 ]. These activities included the modulation of innate immunity by agonizing toll-like receptor (TLR) 2, TLR4 and TLR5, the induction of antimicrobial peptides, the inhibition of cytokine production by T helper (Th) 1, Th2 and Th17 cells, and the inhibition of protease-activated receptor (PAR) 2 and thymic stromal lymphopoietin (TSLP).…”