The reduction of cholesteryl linoleate in lipoproteins: an index of clinical severity in β-thalassemia/Hb E

Abstract

This study suggests that cholesteryl linoleate is the primary target of oxidative modification induced by NTBI in beta-thal/Hb E patients and that reduction in cholesteryl linoleate in lipoproteins could be used as a severity index for beta-thal/Hb E.

Paraoxonase and Arylesterase Activity With Oxidative Status in Children With Thalassemia Major

“…These results support a possible role of oxidative stress in the decrease in paraoxonase activity in b-thalassemia/hemoglobin E patients. 29 Unlike the earlier studies, 28,29 there was no correlation among TAC, TOS, OSI, and paraoxonase, arylesterase in this study. However, there was negative correlation between LOOH and paraoxonase.…”

Pharmaco/ferrokinetic-related pro-oxidant activity of deferiprone inβ-thalassemia

“…The existence of NTBI has been assumed to be a potential risk for heart and other organ damage. We have previously observed a significant correlation between NTBI and lipid peroxidation of low density lipoprotein from b-thal/ Hb E patients [30]. In this study, correlation between NTBI and DMPO-C or ascorbyl radical indicated that NTBI partially contributes to the generation of free radical in serum of the thalassemic patients.…”

“…In addition, low levels of antioxidants in thalassemic serum could also be a factor for the presence of DMPO-C adduct. Negligible levels of serum a-tocopherol and other antioxidants have been previously reported in thalassemia subjects [29,30].…”

Paraoxonase and platelet-activating factor acetylhydrolase activities in lipoproteins of β-thalassemia/hemoglobin E patients

“…Levels of a-tocopherol, free cholesterol and cholesteryl esters in plasma, LDL and HDL were determined using an HPLC method described elsewhere (12). Plasma triglycerides and total cholesterol were measured using commercially available enzymatic assay kits (B.M.…”

“…Oxidative stress and the degree of clinical severity have been shown to be related to abnormal lipid composition of lipoproteins in these patients (12). Oxidative stress and the degree of clinical severity have been shown to be related to abnormal lipid composition of lipoproteins in these patients (12).…”