Paraoxonase and Arylesterase Activity With Oxidative Status in Children With Thalassemia Major

Çakmak, Alpay; Söker, Murat; Köç, Ahmet; Erel, Özcan

doi:10.1097/mph.0b013e3181acd93d

Cited by 20 publications

(19 citation statements)

References 28 publications

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“…In β-thalassaemia major patients, increased free-radical production, peroxidative damage to tissues and depletion of endogenous antioxidants have been expected and may be a major cause of haemolysis 34. Cakmak et al reported peroxidative damage to lipids and proteins in β-thalassaemia major patients, that is, indicated by about a twofold increase in the serum MDA/thiobarbituric acid with a significant decrement in the serum TAC owing to depletion of lipid-soluble antioxidants 35. In contrast, another study found that freshly drawn red blood cells from β-thalassaemia and Eβ-thalassaemia patients do not exhibit any significant increase in the concentration of serum MDA.…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase-1 and oxidative status in common Mediterranean β-thalassaemia mutations trait, and their relations to atherosclerosis

Labib

Etewa²,

Gaber³

et al. 2011

J Clin Pathol

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Section: Discussionmentioning

confidence: 99%

Paraoxonase-1 and oxidative status in common Mediterranean β-thalassaemia mutations trait, and their relations to atherosclerosis

Labib

Etewa²,

Gaber³

et al. 2011

J Clin Pathol

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“…Although the etiology of MS is not yet clear, inflammation plays an important role 13. Other studies indicate that oxidative stress has a major role in the etiology of MS 14. In addition, ischemia modified albumin, a highly sensitive marker for ischemia, is elevated in MS patients 15.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological assessment in patients with long term hypoxia

İlik

Kayhan

Karamanli

et al. 2016

NSJ

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Objective:To evaluate visual evoked potentials (VEP) patterns in chronic obstructive pulmonary disease (COPD) patients who were compliant with supplemental oxygen treatment relative to non-compliant COPD patients.Methods:This prospective study protocol was reviewed and approved by the local ethical committee of Selcuk University and the research was performed in the Department of Neurology, Elbistan State Hospital, Kahramanmaras, Turkey from May to October 2014. Blood gas measurements and pulmonary function tests were carried out in patients with advanced stage COPD. The VEP was assessed in both eyes in both compliant and non-compliant patients.Results:The study included 43 patients; 24 (55.8%) of the patients were not in compliance with their supplemental oxygen treatment, while 19 patients (44.2%) received adequate oxygen treatment. There was no statistically significant difference between patients with regards to pulmonary function test results and blood gas measurements. The VEP latency was significantly greater in both eyes of the non-compliant patients.Conclusion:Previous studies have reported prolonged VEP latencies in inflammatory diseases of the central nervous system. Similar electrophysiological findings were observed in our study and we propose that this may be due to oxidative stress, and inflammation that occurs secondary to chronic ischemia.

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“…The assay is calibrated with hydrogen peroxide and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre (lmol H 2 O 2 equiv./L). The ratio of the total peroxide to the total antioxidant potential gives the OSI, a marker of the degree of oxidative stress [9,10].…”

Section: Measurement Of Total Oxidant-antioxidant Statusmentioning

confidence: 99%

“…The ratio of total oxidative status (TOS) level to total antioxidant status (TAS) level is regarded as the oxidative stress index (OSI). This has been used as a new marker of the degree of oxidative stress [9,10]. It has been found that OSI and TOS are increased in patients with diabetic nephropathy compared to diabetic patients without nephropathy [10].…”

Section: Introductionmentioning

confidence: 99%

“…Also, ROS is considered to have an important role in the development of neuropathy in patients with DM [6,7]. Oxidative stress has been referred to as an oxidant/antioxidant imbalance, occurring when the net amount of oxidant exceeds the antioxidant capacity [8][9][10]. The ratio of total oxidative status (TOS) level to total antioxidant status (TAS) level is regarded as the oxidative stress index (OSI).…”

Section: Introductionmentioning

confidence: 99%

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Serum prolidase activity and oxidative status in patients with diabetic neuropathy

et al. 2011

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We found no data in the literature related to oxidative stress index (OSI), total oxidative status (TOS) and prolidase activity in patients with diabetic neuropathy (DN). In this study, we aimed to evaluate the oxidative status of DN patients via measurement of TOS and serum total antioxidant status (TAS) and estimation of OSI using new automated methods. Thirty-eight healthy participants, 40 diabetic patients without neuropathy, and 39 patients with DN were included. Electrophysiological and neurological examinations were performed. The activity of prolidase and levels of TOS and TAS were determined in the serum of patients. The level of TAS was lower, while the levels of TOS and OSI, and activity of prolidase were higher in both DN and diabetic control groups compared with the healthy subjects (p < 0.05). Prolidase activity was found to be higher in the DN group than in the diabetic control group (p = 0.001). In conclusion, the presence of high TOS and OSI levels together with low levels of TAS in diabetic patients with or without neuropathy may support a role of oxidative stress in the pathogenesis of diabetes mellitus. In addition, increased serum prolidase activity in DN may be interpreted as evidence of increased collagen turnover.

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Paraoxonase and Arylesterase Activity With Oxidative Status in Children With Thalassemia Major

Cited by 20 publications

References 28 publications

Paraoxonase-1 and oxidative status in common Mediterranean β-thalassaemia mutations trait, and their relations to atherosclerosis

Paraoxonase-1 and oxidative status in common Mediterranean β-thalassaemia mutations trait, and their relations to atherosclerosis

Electrophysiological assessment in patients with long term hypoxia

Serum prolidase activity and oxidative status in patients with diabetic neuropathy

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