Paraoxonase-1 and oxidative status in common Mediterranean β-thalassaemia mutations trait, and their relations to atherosclerosis

Abstract

Oxidative stress is increased, while serum PON1 activity is decreased in BTT subjects. Decrease in PON1 activity is associated with the degree of oxidative stress, anaemia and increase in CIMT. Therefore, BTT subjects may be more prone to development of atherosclerosis.

Foxo3 gene expression and oxidative status in beta-thalassemia minor subjects

“…In several studies, an increase of oxidative stress has been reported in both β-thalassemia major and intermedia. The increase of oxidative damage in thalassemia has been related to the generation of free radicals by an excess of denatured α- or β-globin chains, intracellular iron overload and low concentration of normal hemoglobin 7, 8, 9, 10, 11…”

“…However, oxidative stress has been found to be increased in both β-thalassemia subgroups. In contrast, little is known about the oxidative status in BTM subjects, although Selek et al 6 and Labib et al 11 concluded that oxidative stress is increased. Furthermore, little is known about the relation of oxidative status in BTM subjects with different β-thalassemia mutations.…”

Coenzyme Q10Levels in β-Thalassemia and its Association with Ferritin Levels and Chelation Therapy

“…In β-thal, the excess unpaired α-globin chains denature and autoxidize, contributing to increased oxidants, ineffective erythropoiesis, hemolysis and shortened erythrocyte survival (20). In recent studies, increased oxidative stress and decreased serum paraoxanase 1 (PON1) activity which protects LDL from oxidation was shown in β-thal trait patients (21,22). Indeed, genetic resistance to malaria was reported in thalassemia carriers, which is thought to be sourced by the increased oxidation of RBCs that reduce invasions of erythrocytes by the Plasmodium falciparum parasite or impairs parasite survival and development within the cell (23).…”

Benefits of Curcumin Supplementation on Antioxidant Status in β-Thalassemia Major Patients: A Double-Blind Randomized Controlled Clinical Trial

“…The free iron contributes in chemical reactions that generate oxygen radicals and causes damage in vital organs including heart, liver and endocrine glands, depending on the final location of its deposition [3,8]. It is documented that in patients with β-thalassemia major, levels or activity of antioxidant enzymes such as catalase and superoxide dismutase (SOD), serum total antioxidant capacity (TAC) and vitamin E are significantly depressed because of the increased need to neutralize the oxidative stress, while malondialdehyde (MDA) level as a lipid peroxidation index is elevated [1,9,10,11,12]. …”

“…In recent years, curcumin has attracted much attention due to its significant therapeutic potential such as cancer-preventive measures and immunomodulatory and antioxidant activities [16,17]. In addition, some in vitro and animal studies have demonstrated that curcumin has iron-binding capacity and induces iron depletion [10,11,12,13,14]. …”