The Redox Status in Rats Treated with Flaxseed Oil and Lead-Induced Hepatotoxicity

Moneim, Ahmed E. Abdel; Dkhil, Mohamed A.; Al‐Quraishy, Saleh

doi:10.1007/s12011-010-8882-z

Cited by 82 publications

(42 citation statements)

References 47 publications

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“…In addition, the hepatocytes lost their normal architecture and vacuolization with pyknotic nuclei appeared in the cytoplasm. These results are in agreement with the results of Abdel-Moneim et al [46]. Our histological investigations of renal tissue revealed that Pb-acetate treatment results in progressive glomerular and tubular alterations.…”

Section: Discussionsupporting

confidence: 94%

Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female Rats

Abdou

Hassan

2014

BioMed Research International

111

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The present study was conducted to investigate the protective role of Omega-3 polyunsaturated fatty acids against lead acetate-induced toxicity in liver and kidney of female rats. Animals were divided into four equal groups; group 1 served as control while groups 2 and 3 were treated orally with Omega-3 fatty acids at doses of 125 and 260 mg/kg body weight, respectively, for 10 days. These groups were also injected with lead acetate (25 mg/kg body weight) during the last 5 days. Group 4 was treated only with lead acetate for 5 days and served as positive control group. Lead acetate increased oxidative stress through an elevation in MDA associated with depletion in antioxidant enzymes activities in the tissues. Moreover, the elevation of serum enzymes activities (ALT, AST, ALP, and LDH) and the levels of urea and creatinine were estimated but total proteins were decreased. Also, lead acetate-treatment induced hyperlipidemia via increasing of lipid profiles associated with decline in HDL-c level. Significant changes of Hb, PCV, RBCs, PLT, and WBCs in group 4 were recorded. The biochemical alterations of lead acetate were confirmed by histopathological changes and DNA damage. The administration of Omega-3 provided significant protection against lead acetate toxicity.

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Section: Discussionsupporting

confidence: 94%

Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female Rats

Abdou

Hassan

2014

BioMed Research International

111

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“…These results are in accordance with those obtained previously for punica [36] and for silymarin [37].…”

Section: Effect On Oxidative Stress Biomarkerssupporting

confidence: 93%

Effect of Punica and Silymarin on Hepatotoxicity Induced by Pesticides

Abdel-Ghany

Anis

Bihery

et al. 2016

Afro-Egyptian Journal of Infectious and Endemic Diseases

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“…Ibrahim et al (27) reported elevated plasma bilirubin levels in rats that were treated with lead acetate. Similarly, when examining rats exposed to lead through intraperitoneal injections, Abdel-Moneim et al (37) observed elevated serum bilirubin concentrations. Berrahal et al (34) observed significantly increased plasma bilirubin levels in rats that had been injected with 15 mg/kg of lead acetate.…”

Section: Discussionmentioning

confidence: 94%

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Dobrakowski¹,

Zalejska–Fiolka²,

Wielkoszyński³

et al. 2014

Med Pr

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Background: The role of non-enzymatic antioxidants, such as uric acid, albumin, bilirubin, and α-tocopherol, in lead poisoning remains unclear. Therefore, the aim of the study was to explore the association between occupational exposure to lead and nonenzymatic antioxidant concentrations in serum and plasma. Material and Methods: The study population consisted of 278 healthy male employees of lead-zinc plants, with 129 workers classified as having low lead exposure (blood lead level -PbB = 20-39.9 μg/dl) and 149 workers classified as having high lead exposure (PbB = 40-59.8 μg/dl). The control group was composed of 73 healthy male administrative workers. No one from this group had blood lead level or zinc protoporphyrin (ZPP) level greater than normal levels, being 10 μg/dl and 2.5 μg/g of hemoglobin, respectively. In addition to the levels of PbB and ZPP, serum levels of uric acid (UA), albumin, thiol groups of albumin, and bilirubin were determined. The ferric reducing ability of plasma (FRAP) and the plasma level of α-tocopherol were also evaluated. Results: Lead exposure indices were significantly elevated in the examined subgroups as compared with the controls. Serum uric acid levels were significantly elevated in both subgroups, particularly in the group with high exposure. Serum bilirubin concentration was significantly elevated in the group with high exposure compared with the control group, while in the group with low exposure, it showed only a non-significant trend towards an increase. In contrast, ferric-reducing ability of plasma was not significantly greater in the examined subgroups as compared with the control group. Nevertheless, levels of albumin, thiol groups of albumin, and α-tocopherol levels were significantly decreased in the exposed subgroups compared with the control group. Conclusions: Occupational exposure to lead interferes with the blood non-enzymatic antioxidant system. Med Pr 2014;65(4): [443][444][445][446][447][448][449][450][451]

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The Redox Status in Rats Treated with Flaxseed Oil and Lead-Induced Hepatotoxicity

Cited by 82 publications

References 47 publications

Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female Rats

Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female Rats

Effect of Punica and Silymarin on Hepatotoxicity Induced by Pesticides

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

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