The Rediscovery of Honey for Skin Repair: Recent Advances in Mechanisms for Honey-Mediated Wound Healing and Scaffolded Application Techniques

Angioi, Roberta; Morrin, Aoife; White, Blánaid

doi:10.3390/app11115192

Cited by 13 publications

(10 citation statements)

References 162 publications

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“…Furthermore, all the nutritious components present in honey (sugars, amino acids, vitamins, and other trace elements) stimulate cell growth and the development of repair tissues [70][71][72]79,80]. In addition, re-epithelialization would also be promoted by the incre-ment of TNF-α and interleukin-1β (IL-1β) levels.…”

Section: Healing-rate Promotermentioning

confidence: 99%

Role of Honey in Advanced Wound Care

et al. 2021

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Honey is a natural product rich in several phenolic compounds, enzymes, and sugars with antioxidant, anticarcinogenic, anti-inflammatory, and antimicrobial potential. Indeed, the development of honey-based adhesives for wound care and other biomedical applications are topics being widely investigated over the years. Some of the advantages of the use of honey for wound-healing solutions are the acceleration of dermal repair and epithelialization, angiogenesis promotion, immune response promotion and the reduction in healing-related infections with pathogenic microorganisms. This paper reviews the main role of honey on the development of wound-healing-based applications, the main compounds responsible for the healing capacity, how the honey origin can influence the healing properties, also highlighting promising results in in vitro and in vivo trials. The challenges in the use of honey for wound healing are also covered and discussed. The delivery methodology (direct application, incorporated in fibrous membranes and hydrogels) is also presented and discussed.

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Section: Healing-rate Promotermentioning

confidence: 99%

Role of Honey in Advanced Wound Care

et al. 2021

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“…Various honey-based products are available on the market, such as Activon ® , L-Mesitran™, MediHoney ® , Revamil ® , and Principelle IF ® . Each of these examples has been approved for medical use with different indications by the FDA [ 34 ], as summarised in Table 2 .…”

Section: Honey For Wound Healingmentioning

confidence: 99%

Recent Advances in Honey-Based Nanoparticles for Wound Dressing: A Review

et al. 2022

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Wounds with impaired healing, including delayed acute injuries and chronic injuries, generally fail to progress through normal healing stages. A deeper understanding of the biochemical processes involved in chronic wound cures is necessary to correct the microenvironmental imbalances in the wound treatment designs of products. The therapeutic benefits of honey, particularly its antimicrobial activity, make it a viable option for wound treatment in a variety of situations. Integration with nanotechnology has opened up new possibilities not only for wound healing but also for other medicinal applications. In this review, recent advances in honey-based nanoparticles for wound healing are discussed. This also covers the mechanism of the action of nanoparticles in the wound healing process and perspectives on the challenges and future trends of using honey-based nanoparticles. The underlying mechanisms of wound healing using honey are believed to be attributed to hydrogen peroxide, high osmolality, acidity, non-peroxide components, and phenols. Therefore, incorporating honey into various wound dressings has become a major trend due to the increasing demand for combination dressings in the global wound dressing market because these dressings contain two or more types of chemical and physical properties to ensure optimal functionality. At the same time, their multiple features (low cost, biocompatibility, and swelling index) and diverse fabrication methods (electrospun fibres, hydrogels, etc.) make them a popular choice among researchers.

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“…Natural compounds have been reported as a promising alternative against infections. They have been traditionally widely explored for wound healing treatment in various cultures, mainly based on the use of plants as primitive wound dressings, and late by researchers, who confirmed the antibacterial, antioxidant and antifungal activity of certain compounds, among other activities [178,179].…”

Section: Natural Compoundsmentioning

confidence: 99%

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

et al. 2021

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3D printing has been widely used for the personalization of therapies and on-demand production of complex pharmaceutical forms. Recently, 3D printing has been explored as a tool for the development of topical dosage forms and wound dressings. Thus, this review aims to present advances related to the use of 3D printing for the development of pharmaceutical and biomedical products for topical skin applications, covering plain dressing and products for the delivery of active ingredients to the skin. Based on the data acquired, the important growth in the number of publications over the last years confirms its interest. The semisolid extrusion technique has been the most reported one, probably because it allows the use of a broad range of polymers, creating the most diverse therapeutic approaches. 3D printing has been an excellent field for customizing dressings, according to individual needs. Studies discussed here imply the use of metals, nanoparticles, drugs, natural compounds and proteins and peptides for the treatment of wound healing, acne, pain relief, and anti-wrinkle, among others. The confluence of 3D printing and topical applications has undeniable advantages, and we would like to encourage the research groups to explore this field to improve the patient’s life quality, adherence and treatment efficacy.

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The Rediscovery of Honey for Skin Repair: Recent Advances in Mechanisms for Honey-Mediated Wound Healing and Scaffolded Application Techniques

Cited by 13 publications

References 162 publications

Role of Honey in Advanced Wound Care

Role of Honey in Advanced Wound Care

Recent Advances in Honey-Based Nanoparticles for Wound Dressing: A Review

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

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