The red-light emitting diode irradiation increases proliferation of human bone marrow mesenchymal stem cells preserving their immunophenotype

Lewandowski, Rafał; Stępińska, Małgorzata; Gietka, Andrzej; Dobrzyńska, Monika; Łapiński, M; Trafny, Elżbieta Anna

doi:10.1080/09553002.2021.1876947

Cited by 2 publications

(1 citation statement)

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“…Over the last few years, numerous low oxygen priming approaches have been explored for MSC clinical application [ 35 , 36 ]. MSCs growing under hypoxia [ 37 ] demonstrate enhanced proliferation, immunomodulatory properties [ 38 – 43 ], efficient survival, and neovascularization after grafting.…”

Section: Introductionmentioning

confidence: 99%

Insight in Hypoxia-Mimetic Agents as Potential Tools for Mesenchymal Stem Cell Priming in Regenerative Medicine

Nowak-Stępniowska

Osuchowska

Fiedorowicz

et al. 2022

Stem Cells International

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Hypoxia-mimetic agents are new potential tools in MSC priming instead of hypoxia incubators or chambers. Several pharmaceutical/chemical hypoxia-mimetic agents can be used to induce hypoxia in the tissues: deferoxamine (DFO), dimethyloxaloylglycine (DMOG), 2,4-dinitrophenol (DNP), cobalt chloride (CoCl2), and isoflurane (ISO). Hypoxia-mimetic agents can increase cell proliferation, preserve or enhance differentiation potential, increase migration potential, and induce neovascularization in a concentration- and stem cell source-dependent manner. Moreover, hypoxia-mimetic agents may increase HIF-1α, changing the metabolism and enhancing glycolysis like hypoxia. So, there is clear evidence that treatment with hypoxia-mimetic agents is beneficial in regenerative medicine, preserving stem cell capacities. These agents are not studied so wildly as hypoxia but, considering the low cost and ease of use, are believed to find application as pretreatment of many diseases such as ischemic heart disease and myocardial fibrosis and promote cardiac and cartilage regeneration. The knowledge of MSC priming is critical in evaluating safety procedures and use in clinics. In this review, similarities and differences between hypoxia and hypoxia-mimetic agents in terms of their therapeutic efficiency are considered in detail. The advantages, challenges, and future perspectives in MSC priming with hypoxia mimetic agents are also discussed.

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