The Recruitment Innovation Center: Developing novel, person-centered strategies for clinical trial recruitment and retention

Abstract

This version may be subject to change during the production process.

Recruitment and retention for chronic pain clinical trials: a narrative review

“…4,98 The initial cohort of awarded HEAL Pain Management studies includes investigations of the effectiveness of nonpharmacological pain treatments such as cognitive behavioral and psychosocial interventions, and combinations of cognitive and drug treatments, to reduce pain associated with surgery, cancer treatment, osteoarthritis, and caesarean section. 106 The Trial Innovation Network (TIN) is a partnership between 3 Trial Innovation Centers, the Recruitment Innovation Center (RIC) 139 and the Clinical and Translational Science Award institutions, sponsored by the National Center for Advancing Translational Sciences, to develop and test innovations for conducting clinical trials. 7 These national initiatives have received supplemental funding to provide expertise and coordination to the HEAL Pain Effectiveness Research Network.…”

A secondary qualitative analysis of stakeholder views about participant recruitment, retention, and adherence in decentralised clinical trials (DCTs)

“…Interviewees described various activities encouraging people to enrol and remain in their DCT, many of which were informed by the involvement of patients and the public. In this way, DCTs are no different from contemporary conventional clinical trials, where it is increasingly recognised that patient and public involvement must be addressed throughout the trial process, from promoting general awareness of trial participation opportunities to disseminating results [ 18 ]. For this reason, we might expect involvement-informed interventions that improve recruitment, retention, and adherence in conventional trials also to be effective in DCTs.…”

What we wish every investigator knew: Top 4 recruitment and retention recommendations from the Recruitment Innovation Center

“…A more detailed account of the RIC's consultations, recruitment resource implementation, and resource evaluation plans has been previously reported on. 6 Investigators can obtain assistance in incorporating these recommendations by accessing free tools and resources on the TIN website, through their local CTSA liaisons, or by submitting a proposal request for a RIC consultation. Future evaluations of RIC resources will also be deposited in the TIN website for public access.…”

“…The four primary recommendations presented in this paper represent a consensus of opinion among eight RIC consultants, gleaned from several years of consultation experience with study teams. A more detailed account of the RIC's consultations, recruitment resource implementation, and resource evaluation plans has been previously reported on [6]. Investigators can obtain assistance in incorporating these recommendations by accessing free tools and resources on the TIN website, through their local CTSA liaisons, or by submitting a proposal request for a RIC consultation.…”

“…4 Poor recruitment and retention performance is costly to researchers and sponsors and detrimental to public health when advances fail to materialize or do not benefit all. 5 The Recruitment Innovation Center (RIC), 6 part of the Trial Innovation Network's collaborative initiative within the Clinical and Translational Science Award (CTSA) Program, is tasked with addressing critical roadblocks in clinical research. 7 The RIC consults with CTSA hubs and their research teams on strategies to increase clinical trial enrollment by developing, testing, and sharing innovations to enhance participant recruitment and retention.…”