What we wish every investigator knew: Top 4 recruitment and retention recommendations from the Recruitment Innovation Center

Cook, S. K.; Kennedy, Nan; Boone, Leslie R.; Drury, Bethany; Rodweller, Casey; Stroud, Mary; Nelson, Sarah J.; Edwards, Terri; Wilkins, Consuelo H.; Harris, Paul A.

doi:10.1017/cts.2022.370

Cited by 4 publications

(3 citation statements)

References 13 publications

(13 reference statements)

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“…Enhancing participation in clinical trials among historically underrepresented populations is a TIN challenge and commitment. Based on numerous TIN consultations, the RIC has developed recommendations to engage diverse communities in clinical trials, including proactively assessing recruitment and retention barriers, minimizing burden while returning value to participants, prioritizing data-driven site selection, and establishing multistage stakeholder engagement with minoritized communities …”

Section: Mrct Challenges and Tin Responsesmentioning

confidence: 99%

Leveraging the Expertise of the CTSA Program to Increase the Impact and Efficiency of Clinical Trials

Harris,

Dunsmore,

Atkinson

et al. 2023

JAMA Netw Open

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ImportanceMulticenter clinical trials play a critical role in the translational processes that enable new treatments to reach all people and improve public health. However, conducting multicenter randomized clinical trials (mRCT) presents challenges. The Trial Innovation Network (TIN), established in 2016 to partner with the Clinical and Translational Science Award (CTSA) Consortium of academic medical institutions in the implementation of mRCTs, consists of 3 Trial Innovation Centers (TICs) and 1 Recruitment Innovation Center (RIC). This unique partnership has aimed to address critical roadblocks that impede the design and conduct of mRCTs, in expectation of accelerating the translation of novel interventions to clinical practice. The TIN’s challenges and achievements are described in this article, along with examples of innovative resources and processes that may serve as useful models for other clinical trial networks providing operational and recruitment support.ObservationsThe TIN has successfully integrated more than 60 CTSA institution program hubs into a functional network for mRCT implementation and optimization. A unique support system for investigators has been created that includes the development and deployment of novel tools, operational and recruitment services, consultation models, and rapid communication pathways designed to reduce delays in trial start-up, enhance recruitment, improve engagement of diverse research participants and communities, and streamline processes that improve the quality, efficiency, and conduct of mRCTs. These resources and processes span the clinical trial spectrum and enable the TICs and RIC to serve as coordinating centers, data centers, and recruitment specialists to assist trials across the National Institutes of Health and other agencies. The TIN’s impact has been demonstrated through its response to both historical operational challenges and emerging public health emergencies, including the national opioid public health crisis and the COVID-19 pandemic.Conclusions and RelevanceThe TIN has worked to reduce barriers to implementing mRCTs and to improve mRCT processes and operations by providing needed clinical trial infrastructure and resources to CTSA investigators. These resources have been instrumental in more quickly and efficiently translating research discoveries into beneficial patient treatments.

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Section: Mrct Challenges and Tin Responsesmentioning

confidence: 99%

Leveraging the Expertise of the CTSA Program to Increase the Impact and Efficiency of Clinical Trials

Harris,

Dunsmore,

Atkinson

et al. 2023

JAMA Netw Open

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“…The Recruitment Innovation Center (RIC) [ 9 , 10 ] Recruitment Materials resource line was developed to ensure study teams have resources to develop customized, authentic, engaging, culturally appropriate materials to maximize their impact. Broadly, the RIC works with Clinical and Translational Science Award (CTSA) hubs and their researchers to develop, test, and disseminate a range of innovations and resources to support studies’ recruitment and retention needs [ 11 ]. The Recruitment Materials resource line offers support for a variety of clinician- and participant-facing tools, including review and consultation on print materials, websites, and social media, as well as custom design, logos, templates, and development of mobile study applications.…”

Section: The Recruitment Innovation Centermentioning

confidence: 99%

The RIC Recruitment & Retention Materials Toolkit – a resource for developing community-informed study materials

Mayers,

Cook,

Rantala

et al. 2023

J. Clin. Trans. Sci.

Self Cite

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Clinical trials face many challenges with meeting projected enrollment and retention goals. A study's recruitment materials and messaging convey necessary key information and therefore serve as a critical first impression with potential participants. Yet study teams often lack the resources and skills needed to develop engaging, culturally tailored, and professional-looking recruitment materials. To address this gap, the Recruitment Innovation Center recently developed a Recruitment & Retention Materials Content and Design Toolkit, which offers research teams guidance, actionable tips, resources, and customizable templates for creating trial-specific study materials. This paper seeks to describe the creation and contents of this new toolkit.

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“…While dissemination has been acknowledged to have highly variable definitions, we have used the term to refer to an intentional, active process of spreading information to target audiences (Baumann et al, 2022). Previous studies have shown that sharing summary research results (aggregate findings) with participants is an important practice that benefits both participants and researchers (Cook et al, 2022; Fernandez, Kodish, & Weijer, 2003; Hiratsuka et al, 2012; O'Daniel & Haga, 2011) with benefits including: building trust between communities and researchers, encouraging future research participation and understanding, and thanking participants for their contributions (Cook et al, 2022; Fernandez, Kodish, & Weijer, 2003; Hiratsuka et al, 2012; O'Daniel & Haga, 2011). Study participants largely desire to receive aggregate research findings and appreciate research teams who prioritize this practice (Aldinger et al, 2018; Dixon‐Woods et al, 2006; Hyams et al, 2016; Purvis et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Genetic counselors' research dissemination practices and attitudes

Blanche,

Wainstein,

Dey

et al. 2023

Journal of Genetic Counseling

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Benefits have been demonstrated to disseminating aggregate research results to all relevant audiences, including study participants. Despite this, many health researchers face barriers in dissemination to broad audiences and returning aggregate results to participants is not commonly practiced. Due to their research presence and training in communication, genetic counselors can lead in implementing best practices in this area. We explored genetic counselors' current practices and opinions regarding educating study participants and wider audiences of research findings. We distributed a survey of 32 multiple‐choice and open‐ended questions to National Society of Genetics Counselors (NSGC) and Canadian Association of Genetic Counsellors (CAGC) members. Most respondents (90.1%, n = 128/142) identified with a responsibility to disseminate their research findings to a broad audience and identified several associated benefits. All respondents saw value in communicating aggregate results to study participants, although over half (53.2%, n = 66/124) had never done so. Genetic counselors reported resource and knowledge barriers to research dissemination. Despite expertise in education and communication, genetic counselors face similar barriers as other researchers toward broad dissemination of research. Formal training and professional guidelines specific to research dissemination practices will equip genetic counselors to reach broader audiences and maximize the impact of research findings.

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What we wish every investigator knew: Top 4 recruitment and retention recommendations from the Recruitment Innovation Center

Abstract: This version may be subject to change during the production process.

Cited by 4 publications

References 13 publications

Leveraging the Expertise of the CTSA Program to Increase the Impact and Efficiency of Clinical Trials

Leveraging the Expertise of the CTSA Program to Increase the Impact and Efficiency of Clinical Trials

The RIC Recruitment & Retention Materials Toolkit – a resource for developing community-informed study materials

Genetic counselors' research dissemination practices and attitudes

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