The recombination landscape around forensic STRs: Accurate measurement of genetic distances between syntenic STR pairs using HapMap high density SNP data

Phillips, C.; Ballard, David J.; Gill, Pooria; Court, Denise Syndercombe; Carracedo, Ángel; Lareu, M.V.

doi:10.1016/j.fsigen.2011.07.012

Cited by 72 publications

(43 citation statements)

References 21 publications

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“…In comparing θ s computed from our family samples with those estimated from European families, such as Germans , Italian , Greenlanders, Danes, and Somalis , and European and Asian , our results are in agreement with European and Asian , German except DXS8377‐DXS7423, Italian except DXS6809‐DXS6789, Greenlanders, Danes, and Somalis except DXS10079‐DXS10074. But the θ s of DXS7132‐DXS10079, DXS10079‐DXS10074, DXS10074‐DXS10075, DXS6809‐DXS6789, and DXS7424‐DXS101 from HapMap are below the lower limit of 95% CIs of our studied results. Differences of X‐STR recombination rates among populations may be different.…”

Section: Discussioncontrasting

confidence: 75%

X chromosomal recombination—A family study analyzing 26 X‐STR Loci in Chinese Han three‐generation pedigrees

Liu

et al. 2013

Electrophoresis

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The aim of this study is to investigate genetic linkage and recombination fractions of 26 X chromosomal (X-STR) loci with two multiplex PCR systems (MX15-STR and MX12-STR). MX15-STR (including DXS7133, DXS6801, DXS981, DXS6809, DXS7424, DXS6789, DXS9898, DXS7132, GATA165B12, DXS101, DXS10075, DXS6800, GATA31E08, DXS10074, and DXS10079) and MX12-STR (including DXS6854, DXS9902, DXS6800, GATA172D05, DXS7423, HPRTB, DXS6807, DXS6803, DXS6804, DXS6799, DXS8378, and DXS8377) were successful analyzed on 206 two-generation families with two or more children and 33 three-generation families with 72 grandsons. Segregation analysis and calculation of recombination fractions between pairs of markers were performed. Linkage analysis of pairs of markers showed that there existed significant linkage (maximum LOD scores >2.0) within the physical distance of 48.5 Mb. Recombination events could be observed within the clusters of closed linked makers spanning <1.0 Mb. These results indicate that close cluster X-STRs used and recombination fractions of the selected loci will be very useful for biostatistical calculations in complex kinship analysis.

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Section: Discussioncontrasting

confidence: 75%

X chromosomal recombination—A family study analyzing 26 X‐STR Loci in Chinese Han three‐generation pedigrees

Liu

et al. 2013

Electrophoresis

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“…In contrast to only one pair of closely located loci in Identifiler [17]. The recombination rates of <0.5 in these locus pairs do not mean independent assortment.…”

Section: Linkage Between Locimentioning

confidence: 85%

Evaluation of advanced multiplex short tandem repeat systems in pairwise kinship analysis

et al. 2015

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“…Calculation of probability that the grandfather could be the alleged father was performed under consideration of linkage between the loci VWA/D12S391 (θ = 0.1172), Penta D/ D21S11 (θ = 0.3568) and D5S818/CS-F1PO (θ = 0.2522, [15]) using LINKAGE 5.1 plus manual adaptation to include the mutational events.…”

Section: Methodsmentioning

confidence: 99%

Usefulness of SNPs as Supplementary Markers in a Paternity Case with 3 Genetic Incompatibilities at Autosomal and Y Chromosomal Loci

Lindner

Wurmb‐Schwark

Meier

et al. 2014

Transfus Med Hemother

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Background: In kinship testing, investigation of 15 short tandem repeats (STRs) usually provides decisive genetic information for resolving relationship cases. However, in complex deficiency cases, in cases with more than 2 mutations at different STR loci or when close (untested) relatives of the alleged father are suggested to be the biological father of the child, STR typing alone may not be sufficient. In these cases, the application of supplementary markers such as single nucleotide polymorphisms (SNPs) is recommended. Methods: We describe a paternity case with 3 genetic incompatibilities (Penta D, VWA, and DYS385) between the alleged father and the child after analyzing 23 autosomal and 16 Y chromosomal STR loci. The question arose as to whether the alleged father could be excluded and a related person could be the biological father of the child, or whether the observed genetic incompatibilities were mutations. Interestingly, the 2 excluded full brothers of the alleged father possessed identical genetic incompatibilities at locus VWA and DYS385 as the alleged father. Results and Conclusions: Additional performance of a 50-plex SNP assay demonstrated that the observed mismatches were indeed mutations and the alleged father was the biological father of the child. The results show the usefulness of SNPs as supplementary markers in relationship testing when STR analyses show ambiguous results.

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The recombination landscape around forensic STRs: Accurate measurement of genetic distances between syntenic STR pairs using HapMap high density SNP data

Cited by 72 publications

References 21 publications

X chromosomal recombination—A family study analyzing 26 X‐STR Loci in Chinese Han three‐generation pedigrees

X chromosomal recombination—A family study analyzing 26 X‐STR Loci in Chinese Han three‐generation pedigrees

Evaluation of advanced multiplex short tandem repeat systems in pairwise kinship analysis

Usefulness of SNPs as Supplementary Markers in a Paternity Case with 3 Genetic Incompatibilities at Autosomal and Y Chromosomal Loci

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