The Receptors for Nerve Growth Factor and Other Neurotrophins

Raffioni, Simona; Bradshaw, Ralph A.; Buxser, Stephen E.

doi:10.1146/annurev.bi.62.070193.004135

Cited by 116 publications

(38 citation statements)

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“…After this novel approach had turned out to work for L2A, it was utilized to address the question of neurotrophin binding within the LRM3-cassette of TrkB. TrkB, in contrast to TrkA, has three different ligands, BDNF, NT-3 and NT-4 [8,24] and therefore represents a much more complex system. Surprisingly, [J25I]BDNF actually bound to the L2B column with an affinity comparable to that of the interaction between L2A and NGF.…”

Section: Resultsmentioning

confidence: 99%

“…TrkA is the biologically functional receptor for nerve growth factor (NGF) [9,13], whereas its homolog TrkB binds three different neurotrophins [3,8,16,24,36] namely brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) [5,14,15,31,32]. The extracellular domains of Trk-type receptors harbor a modular mosaic of potential ligand binding modules, namely two immunoglobulin (Ig)-like domains and an LRM3-cassette consisting of a tandem array of three leucine-rich motifs (LRMs) flanked by cysteine-rich clusters [28].…”

Section: Introductionmentioning

confidence: 99%

“…TrkA and TrkB share 37% amino acid sequence identity in the extracellular domains and 75% in the kinase domains [23,28]. Despite this high degree of similarity, TrkB is a much more versatile receptor than TrkA in that it binds three different ligands [24] with clearly distinguishable pharmacological characteristics [2,22,25,26] leading to distinct biological effects [8,14,15]. In order to show whether the second LRM also plays a role in ligand binding in the TrkB receptor, a peptide corresponding to this region (L2B) was synthesized and characterized in the same way as L2A.…”

Section: Introductionmentioning

confidence: 99%

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Specific neurotrophin binding to leucine‐rich motif peptides of TrkA and TrkB

et al. 1995

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Specific neurotrophin binding to leucine‐rich motif peptides of TrkA and TrkB

et al. 1995

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“…Each of these ligands is required for the survival and differentiation of central and R44 K Linher-Melville and J Li peripheral neurons and signals through distinct high-affinity transmembrane receptor tyrosine kinases, as well as through a common, more widely expressed, low-affinity neurotrophin receptor (NGFR), also known as p75 (Raffioni et al 1993, Snider 1994, Davies 2000. Transcripts for these neurotrophins and their receptors have been detected in the rat ovary before the neonatal phase of development (Dissen et al 1995), indicating a role during ovarian differentiation and the initiation of folliculogenesis in the embryo.…”

Section: Brain-derived Neurotrophic Factormentioning

confidence: 99%

“…NGF signals through NTRK1, also known as TRKA (Raffioni et al 1993), as well as through NGFR. One of the first studies demonstrating that NGF is locally produced in the immature rat ovary showed the presence of an mRNA similar to the mature Ngf mRNA detected in the murine submaxillary gland, an established source of its production (Lara et al 1990).…”

Section: Nerve Growth Factormentioning

confidence: 99%

The roles of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor and nerve growth factor during the final stage of folliculogenesis: a focus on oocyte maturation

Linher‐Melville¹,

Li²

2013

Reproduction

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Neurotrophic factors were first identified to promote the growth, survival or differentiation of neurons and have also been associated with the early stages of ovarian folliculogenesis. More recently, their effects on the final stage of follicular development, including oocyte maturation and early embryonic development, have been reported. Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are expressed in numerous peripheral tissues outside of the CNS, most notably the ovary, are now known to stimulate oocyte maturation in various species, also enhancing developmental competence. The mechanisms that underlie their actions in antral follicles, as well as the targets ultimately controlled by these factors, are beginning to emerge. GDNF, BDNF and NGF, alone or in combination, could be added to the media currently utilized for in vitro oocyte maturation, thereby potentially increasing the production and/or quality of early embryos.Reproduction (2013) 145 R43-R54

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Endogenous nerve growth factor is required for regulation of the low affinity neurotrophin receptor (p75) in sympathetic but not sensory ganglia

Zhou

Rush

1996

J. Comp. Neurol.

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During development, many sympathetic and sensory neurons are dependent on nerve growth factor (NGF) for survival. The low affinity neurotrophin receptor (p75), expressed in these neurons, is regulated by exogenous NGF in vitro and in vivo. However, whether p75 expression in vivo is under the control of endogenous NGF has not been determined. The role of NGF in regulating the expression of p75 in sympathetic and sensory nerves was investigated in Sprague-Dawley rats treated with an antiserum specific for NGF. P75 was differentially regulated. P75 immunoreactivity (-ir) within sympathetic neurons in the superior cervical ganglia (SCG) was reduced after 2 days, and disappeared after 5 days, of treatment with the NGF antiserum. In contrast, a significant increase in p75-ir was detected in nerve bundles within and close to the SCG from 3 to 14 days after treatment. A similar pattern of p75 expression was observed in the stellate and coeliac ganglia. In contrast, p75 expression in nerve terminals of the mesenteric arteries and irides was reduced. However, in the same animals the expression of p75 was not significantly affected by the treatment in dorsal root, trigeminal or nodose ganglia, salivary gland or small intestine. In contrast to p75, the NGF high affinity receptor trkA was little affected in sympathetic neurons by depletion of endogenous NGF for 2 weeks. These results indicate that endogenous NGF is required in sympathetic ganglia for the expression of p75 but not trkA in neurons, but for the down-regulation of p75 in glia. In contrast, endogenous NGF is not essential for the regulation of p75 in neurons or glia within sensory ganglia.

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The Receptors for Nerve Growth Factor and Other Neurotrophins

Cited by 116 publications

References 0 publications

Specific neurotrophin binding to leucine‐rich motif peptides of TrkA and TrkB

Specific neurotrophin binding to leucine‐rich motif peptides of TrkA and TrkB

The roles of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor and nerve growth factor during the final stage of folliculogenesis: a focus on oocyte maturation

Endogenous nerve growth factor is required for regulation of the low affinity neurotrophin receptor (p75) in sympathetic but not sensory ganglia

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