The roles of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor and nerve growth factor during the final stage of folliculogenesis: a focus on oocyte maturation

Linher‐Melville, Katja; Li, Julang

doi:10.1530/rep-12-0219

Cited by 41 publications

(28 citation statements)

References 93 publications

(150 reference statements)

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“…Many of the signaling pathways overrepresented by these targets corresponded to growth factors putatively involved in follicular cell proliferation and steroidogenesis and prevention of premature luteinization including HGF, IGF1, TGFb, estrogen, neurotropin/TRK, PEDF, and NGF (Parrott et al 1993, Salas et al 2006, Glister et al 2010, Mani et al 2010, Garcia-Rudaz et al 2011, Chuderland et al 2013 and others involved in oocyte maturation including neuregulin, GDNF, and EGF (Conti et al 2006, Noma et al 2011, Linher-Melville & Li 2013, the fine-tune regulation of which is of key importance during the final stages of follicle development. Also present were several core cell cycle regulatory pathways (cell cycle regulation by BTG family proteins, estrogen-mediated S phase entry, and G1/S checkpoint regulation), a finding which is consistent with the notion that the development of the dominant follicle involves a substantial decrease in granulosa cell proliferation (Lussier et al 1987, Gaytan et al 1996.…”

Section: Discussionmentioning

confidence: 99%

Characterization of microRNAs differentially expressed during bovine follicle development

Sontakke¹,

Mohammed²,

McNeilly³

et al. 2014

Reproduction

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Several different miRNAs have been proposed to regulate ovarian follicle function; however, very limited information exists on the spatiotemporal patterns of miRNA expression during follicle development. The objective of this study was to identify, using microarray, miRNA profiles associated with growth and regression of dominant-size follicles in the bovine monovular ovary and to characterize their spatiotemporal distribution during development. The follicles were collected from abattoir ovaries and classified as small (4-8 mm) or large (12-17 mm); the latter were further classified as healthy or atretic based on estradiol and CYP19A1 levels. Six pools of small follicles and individual large healthy (nZ6) and large atretic (nZ5) follicles were analyzed using Exiqon's miRCURY LNA microRNA Array 6th gen, followed by qPCR validation. A total of 17 and 57 sequences were differentially expressed (greater than or equal to twofold; P!0.05) between large healthy and each of small and large atretic follicles respectively. Bovine miRNAs confirmed to be upregulated in large healthy follicles relative to small follicles (bta-miR-144, bta-miR-202, bta-miR-451, bta-miR-652, and bta-miR-873) were further characterized. Three of these miRNAs (bta-miR-144, bta-miR-202, and bta-miR-873) were also downregulated in large atretic follicles relative to large healthy follicles. Within the follicle, these miRNAs were predominantly expressed in mural granulosa cells. Further, body-wide screening revealed that bta-miR-202, but not other miRNAs, was expressed exclusively in the gonads. Finally, a total of 1359 predicted targets of the five miRNAs enriched in large healthy follicles were identified, which mapped to signaling pathways involved in follicular cell proliferation, steroidogenesis, prevention of premature luteinization, and oocyte maturation.

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Section: Discussionmentioning

confidence: 99%

Characterization of microRNAs differentially expressed during bovine follicle development

Sontakke¹,

Mohammed²,

McNeilly³

et al. 2014

Reproduction

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“…It has been hypothesized that the restorative effects of MSCs transplantation on impaired ovarian function resulted from secretion of trophic factors, which are beneficial to follicle growth [9], [10]. Previous studies reported that AFSCs can secrete TGF-β [51], vascular endothelial growth factor [52], and glia cell-derived neurotrophic factor [53], which are required for follicular development [54], [55], and can inhibit follicular cell apoptosis [56] and follicle atresia [57]. Taken together, we infer that the favorable effects of AFSCs on CTx-damaged ovary is derived from the paracrine secretion of certain beneficial factors, which support ovarian follicle survival.…”

Section: Discussionmentioning

confidence: 99%

Amniotic Fluid Stem Cells Prevent Follicle Atresia and Rescue Fertility of Mice with Premature Ovarian Failure Induced by Chemotherapy

et al. 2014

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Chemotherapy used to treat cancer may cause irreversible premature ovarian failure (POF). Of late, amniotic fluid stem cells (AFSCs) provide a novel source for regenerative medicine because of their primitive stage, low immunogenicity, and easy accessibility. In this study, we isolated AFSCs from transgenic mice that ubiquitously express enhanced green fluorescence protein (EGFP). These AFSCs exhibited morphologies, immunophenotypes, and mesoderm trilineage differentiation potentials similar to mesenchymal stem cells (MSCs). Further, AFSCs proliferated faster than MSCs and expressed OCT4, a marker for pluripotency. To investigate their potential in recovering fertility in POF model, AFSCs were transplanted into the ovaries of mice with POF six weeks post induction using chemotherapeutic drugs, busulfan and cyclophosphamide. AFSCs could rescue the reproductive ability of mice with POF by preventing follicle atresia and sustaining the healthy follicles. Notably, the transplanted AFSCs did not differentiate into granulosa and germline cells in vivo. After one month, the decreased numbers of transplanted AFSCs accompanied with the reduced beneficial effects indicated that the therapeutic efficacy were directly from AFSCs. These findings demonstrated the therapeutic effects of AFSCs and suggested the promise of AFSCs for treating infertility and POF caused by chemotherapy.

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“…NGF has also been recognized as such an ovarian factor [10]. It was identified in the ovary of several species, including the human [11], in which also the pertinent receptors p75 NTR and TrkA were found [12, 13].…”

Section: Introductionmentioning

confidence: 99%

Pro-nerve growth factor in the ovary and human granulosa cells

Meinel

Blohberger

Berg

et al. 2015

Hormone Molecular Biology and Clinical Investigation

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Background Pro-nerve growth factor must be cleaved to generate mature NGF, which was suggested to be a factor involved in ovarian physiology and pathology. Extracellular proNGF can induce cell death in many tissues. Whether extracellular proNGF exists in the ovary and may play a role in the death of follicular cells or atresia was unknown. Material and Methods Immunohistochemistry of human and Rhesus monkey ovarian sections was performed. IVF-derived follicular fluid and human granulosa cells were studied by RT-PCR, qPCR, Western blotting, ATP- and caspase-assays. Results and Conclusions Immunohistochemistry of ovarian sections identified proNGF in granulosa cells and Western blotting of human isolated granulosa cells confirmed the presence of proNGF. Ovarian granulosa cells thus produce proNGF. Recombinant human proNGF even at high concentrations did not affect the levels of ATP or the activity of caspase 3/7, indicating that in granulosa cells proNGF does not induce death. In contrast, mature NGF, which was detected previously in follicular fluid, may be a trophic molecule for granulosa cells with unexpected functions. We found that in contrast to proNGF, NGF increased the levels of the transcription factor early growth response 1 and of the enzyme choline acetyl-transferase. A mechanism for the generation of mature NGF from proNGF in the follicular fluid may be extracellular enzymatic cleavage. The enzyme MMP7 is known to cleave proNGF and was identified in follicular fluid and as a product of granulosa cells. Thus the generation of NGF in the ovarian follicle may depend on MMP7.

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The roles of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor and nerve growth factor during the final stage of folliculogenesis: a focus on oocyte maturation

Cited by 41 publications

References 93 publications

Characterization of microRNAs differentially expressed during bovine follicle development

Characterization of microRNAs differentially expressed during bovine follicle development

Amniotic Fluid Stem Cells Prevent Follicle Atresia and Rescue Fertility of Mice with Premature Ovarian Failure Induced by Chemotherapy

Pro-nerve growth factor in the ovary and human granulosa cells

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