The Receptor Kinases BAK1/SERK4 Regulate Ca2+ Channel-Mediated Cellular Homeostasis for Cell Death Containment

Xiao, Yu; Xu, Guangyuan; Li, Bo; Vespoli, Luciano de Souza; Liu, Hai; Moeder, Wolfgang; Chen, Sixue; Oliveira, Marcos V. V. de; Souza, Suzane Ariádina de; Shao, Wenyong; Rodrigues, Bárbara; Ma, Yi; Chhajed, Shweta; Xue, Shaowu; Berkowitz, Gerald A.; Yoshioka, Keiko; He, Ping; Shan, Libo

doi:10.1016/j.cub.2019.09.018

Cited by 86 publications

(92 citation statements)

References 53 publications

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“…Additionally, Arabidopsis CNGC20 was recently identified as a positive regulator of cell death in bak1/serk4 . BAK1 interacts with and phosphorylates CNGC20 leading to the degradation of CNGC20 (Yu et al 2019). Moreover, CNGC19, which was reported to positively regulate the defense against spodoptera herbivory in Arabidopsis (Meena et al 2019), can suppress the cell death phenotype of bak1 serk4 double mutant in the absence of CNGC20, indicating that SERKs regulate the homeostasis of CNGCs via phosphorylation and the high accumulation of calcium channels or high increase of calcium influx results in cell death (Yu et al 2019).…”

Section: Recent Discoveries Of the Activation Of Immunity Mediated Bymentioning

confidence: 99%

“…BAK1 interacts with and phosphorylates CNGC20 leading to the degradation of CNGC20 (Yu et al 2019). Moreover, CNGC19, which was reported to positively regulate the defense against spodoptera herbivory in Arabidopsis (Meena et al 2019), can suppress the cell death phenotype of bak1 serk4 double mutant in the absence of CNGC20, indicating that SERKs regulate the homeostasis of CNGCs via phosphorylation and the high accumulation of calcium channels or high increase of calcium influx results in cell death (Yu et al 2019). Likewise, the rice OsCNGC9 is required for multiple MAMPs‐induced calcium influx and OsRLCK185 physically associates with and phosphorylates OsCNGC9 to activate the channel activity (Wang et al 2019b), although whether OsCNGC9 requires another member of OsCNGCs together to form a calcium channel needs to be defined.…”

Section: Recent Discoveries Of the Activation Of Immunity Mediated Bymentioning

confidence: 99%

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Plant immune signaling: Advancing on two frontiers

Wang

Feng

Zhou

et al. 2020

JIPB

165

144

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Plants have evolved multiple defense strategies to cope with pathogens, among which plant immune signaling that relies on cell-surface localized and intracellular receptors takes fundamental roles. Exciting breakthroughs were made recently on the signaling mechanisms of pattern recognition receptors (PRRs) and intracellular nucleotide-binding site (NBS) and leucine-rich repeat (LRR) domain receptors (NLRs). This review summarizes the current view of PRRs activation, emphasizing the most recent discoveries about PRRs' dynamic regulation and signaling mechanisms directly leading to downstream molecular events including mitogen-activated protein kinase (MAPK) activation and calcium (Ca 2+ ) burst. Plants also have evolved intracellular NLRs to perceive the presence of specific pathogen effectors and trigger more robust immune responses. We also discuss the current understanding of the mechanisms of NLR activation, which has been greatly advanced by recent breakthroughs including structures of the first full-length plant NLR complex, findings of NLR sensor-helper pairs and novel biochemical activity of Toll/interleukin-1 receptor (TIR) domain.

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Section: Recent Discoveries Of the Activation Of Immunity Mediated Bymentioning

confidence: 99%

Section: Recent Discoveries Of the Activation Of Immunity Mediated Bymentioning

confidence: 99%

Plant immune signaling: Advancing on two frontiers

Wang

Feng

Zhou

et al. 2020

JIPB

165

144

View full text Add to dashboard Cite

show abstract

“…1). This idea is supported by the observation of interactions of CNGCs with receptor kinases and other membrane-localized proteins as discussed above (Table 2; Ladwig et al, 2015;Wang et al, 2019;Yu et al, 2019;Meng et al, 2020). Following the membrane raft hypothesis proposed by Simons and Ikonen (1997), subcompartmentalization of plasma membrane proteins in nanodomains or microdomains may produce signaling hubs that give specificity in plant signaling (Keinath et al, 2010;Demir et al, 2013;Jaillais and Ott, 2020).…”

Section: Cngc Hetero-tetramerization and Localization To Membrane Nanmentioning

confidence: 55%

“…In 2019, three studies revealed that LRR-RLKs and related kinases phosphorylate CNGCs, and examined the physiological relevance of this phosphorylation (Tian et al, 2019;Wang et al, 2019;Yu et al, 2019): Tian et al (2019) reported the relevance of CNGC phosphorylation in the recognition of pathogen/microbeassociated molecular patterns (PAMPs/MAMPs) in…”

Section: Regulation Of Cngc Activation and Turnover By Phosphorylationmentioning

confidence: 99%

“…BAK1 and SERK4 are involved in a wide variety of physiological phenomena and the bak1-4 serk4-1 double mutant develops severe postembryonic lethality due to hyperactivation of PCD (He et al, 2007;de Oliveira et al, 2016). Yu et al (2019) conducted a nonbiased suppressor screen of cell death in RNA interference-BAK1/ SERK4-silenced plants and found that a knockout mutant of CNGC20 suppressed this cell death phenotype. Furthermore, they showed that BAK1 phosphorylates the CT cytosolic domain of CNGC20 (Table 2).…”

Section: Regulation Of Cngc Activation and Turnover By Phosphorylationmentioning

confidence: 99%

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Plant Cyclic Nucleotide-Gated Channels: New Insights on Their Functions and Regulation

2020

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Implantable application of polymer‐based biosensors

Mei

Zhang

et al. 2021

Journal of Polymer Science

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Implantable sensors offer a great opportunity to extract physiological information from inside the body by real-time monitoring. With the demand for personal healthcare and point-of-care treatment, a long-term stable sensor of excellent mechanical and biological compatibility with human organs is urgently required. In contrast to rigid electronic devices using silicon or metallic materials, soft sensors are realized by flexible polymers in a simple way, endowing the implantable sensor with a tissue-mimetic structure. In this article, we systematically review the development of implantable electronic sensors based on polymer materials. The unique properties of polymers are introduced, followed by their applications in implantable device fabrication.Strategies to integrate polymers with implantable sensors, encompassing device interface, geometry, and integration, are also summarized. Furthermore, biosensing applications of polymer-based implantable devices are described, ranging from physical stimulus monitoring to biochemical analysis in vivo. Finally, we envision how advances in polymer materials may facilitate the development of intelligent sensors with broader applications in vivo.

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The Receptor Kinases BAK1/SERK4 Regulate Ca2+ Channel-Mediated Cellular Homeostasis for Cell Death Containment

Cited by 86 publications

References 53 publications

Plant immune signaling: Advancing on two frontiers

Plant immune signaling: Advancing on two frontiers

Plant Cyclic Nucleotide-Gated Channels: New Insights on Their Functions and Regulation

Implantable application of polymer‐based biosensors

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