The Recent Development of Acoustic Sensors as Effective Chemical Detecting Tools for Biological Cells and Their Bioactivities

Gouda, Mostafa; Ghazzawy, Hesham S.; Alqahtani, Nashi K.; Liu, Yuanyuan

doi:10.3390/molecules28124855

Cited by 6 publications

(1 citation statement)

References 120 publications

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“…The investigation of molecular interactions can be achieved through many kinds of biosensors [106][107][108], and the OPLI can offer a reliable label-free and real-time sensing option for those studies as well.…”

Section: Molecular Interactionsmentioning

confidence: 99%

From Self-Assembly of Colloidal Crystals toward Ordered Porous Layer Interferometry

Wan

Qian

2023

Biosensors

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Interferometry-based, reflectometric, label-free biosensors have made significant progress in the analysis of molecular interactions after years of development. The design of interference substrates is a key research topic for these biosensors, and many studies have focused on porous films prepared by top-down methods such as porous silicon and anodic aluminum oxide. Lately, more research has been conducted on ordered porous layer interferometry (OPLI), which uses ordered porous colloidal crystal films as interference substrates. These films are made using self-assembly techniques, which is the bottom-up approach. They also offer several advantages for biosensing applications, such as budget cost, adjustable porosity, and high structural consistency. This review will briefly explain the fundamental components of self-assembled materials and thoroughly discuss various self-assembly techniques in depth. We will also summarize the latest studies that used the OPLI technique for label-free biosensing applications and divide them into several aspects for further discussion. Then, we will comprehensively evaluate the strengths and weaknesses of self-assembly techniques and discuss possible future research directions. Finally, we will outlook the upcoming challenges and opportunities for label-free biosensing using the OPLI technique.

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Section: Molecular Interactionsmentioning

confidence: 99%

From Self-Assembly of Colloidal Crystals toward Ordered Porous Layer Interferometry

Wan

Qian

2023

Biosensors

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The importance, benefits, and future of nanobiosensors for infectious diseases

Dhahi,

Dafhalla,

Saad

et al. 2024

Biotech and App Biochem

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Infectious diseases, caused by pathogenic microorganisms such as bacteria, viruses, parasites, or fungi, are crucial for efficient disease management, reducing morbidity and mortality rates and controlling disease spread. Traditional laboratory‐based diagnostic methods face challenges such as high costs, time consumption, and a lack of trained personnel in resource‐poor settings. Diagnostic biosensors have gained momentum as a potential solution, offering advantages such as low cost, high sensitivity, ease of use, and portability. Nanobiosensors are a promising tool for detecting and diagnosing infectious diseases such as coronavirus disease, human immunodeficiency virus, and hepatitis. These sensors use nanostructured carbon nanotubes, graphene, and nanoparticles to detect specific biomarkers or pathogens. They operate through mechanisms like the lateral flow test platform, where a sample containing the biomarker or pathogen is applied to a test strip. If present, the sample binds to specific recognition probes on the strip, indicating a positive result. This binding event is visualized through a colored line. This review discusses the importance, benefits, and potential of nanobiosensors in detecting infectious diseases.

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The effect of probe density coverage on the detection of oenological tannins in quartz crystal microbalance with dissipation monitoring (QCM‐D) experiments

Gagliardi,

Tori,

Sanmartin

et al. 2024

J Sci Food Agric

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BackgroundPolyphenols are a group of compounds found in grapes, musts, and wines. Their levels are crucial for grape ripening, proper must fermentation, and final wine characteristics. Standard chemical analysis is commonly used to detect these compounds, but it is costly, time‐consuming, and requires specialized laboratories and operators. To address this, this study explores a functionalized acoustic sensor for detecting oenological polyphenols.ResultsThe method involves utilizing a Quartz Crystal Microbalance with Dissipation monitoring (QCM‐D) to detect the target analyte by using a gelatin‐based probe layer. The sensor is functionalized by optimizing the probe coverage density to maximize its performance. This is achieved by using 12‐mercaptododecanoic acid (12‐MCA) to immobilize the probe onto the gold sensor surface, and dithiothreitol (DTT) as a reducing and competitive binding agent. The concentration of 12‐MCA and DTT in the solutions is varied to control the probe density. QCM‐D measurements demonstrates that the probe density can be effectively adjusted using this approach, ranging from 0.2×1013 molecules cm—2 to 2×1013 molecules cm—2.This study also investigates the interaction between the probe and tannins, confirming the sensor ability to detect them. Interestingly, the lower probe coverage achieves higher detection signals when normalized to probe immobilization signals. Moreover, significant changes in mechanical properties of the functionalization layer are observed after the interaction with samples.ConclusionThe combination of QCM‐D with gelatin functionalization holds great promise for future applications in the wine industry. It offers real‐time monitoring capabilities, requires minimal sample preparation, and provides high sensitivity for quality control purposes.This article is protected by copyright. All rights reserved.

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The Recent Development of Acoustic Sensors as Effective Chemical Detecting Tools for Biological Cells and Their Bioactivities

Cited by 6 publications

References 120 publications

From Self-Assembly of Colloidal Crystals toward Ordered Porous Layer Interferometry

From Self-Assembly of Colloidal Crystals toward Ordered Porous Layer Interferometry

The importance, benefits, and future of nanobiosensors for infectious diseases

The effect of probe density coverage on the detection of oenological tannins in quartz crystal microbalance with dissipation monitoring (QCM‐D) experiments

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