The ratio of cardiac to vascular .BETA.-receptor blockade of atenolol and propranolol in spontaneously hypertensive rats in vivo.

Kudo, Yoshitaka; Sokabe, Hirofumi

doi:10.1248/bpb1978.5.745

Journal of Pharmacobio-Dynamics

1982

DOI: 10.1248/bpb1978.5.745

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The ratio of cardiac to vascular .BETA.-receptor blockade of atenolol and propranolol in spontaneously hypertensive rats in vivo.

Yoshitaka Kudo¹,

Hirofumi Sokabe²

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1983

1991

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Cited by 2 publications

References 7 publications

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Propranolol and atenolol inhibit norepinephrine spillover rate into plasma in conscious spontaneously hypertensive rats

Keeton

Biediger

1991

Naunyn-Schmiedeberg's Arch Pharmacol

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Radiotracer techniques capable of measuring norepinephrine clearance and spillover rate into plasma were used to test the hypothesis that the antihypertensive effects of propranolol and atenolol in conscious spontaneously hypertensive rats are associated with an inhibition of norepinephrine release from postganglionic sympathetic neurons. The 10%-15% fall in mean arterial pressure produced over 4 h by propranolol (1, 3.3 and 10 mg/kg, s.c.) and atenolol (1, 3.3 and 10 mg/kg, s.c.) was not dose-related, and only the largest dose of propranolol caused a significant bradycardia. Each dose of atenolol significantly lowered heart rate. The decrease in blood pressure caused by propranolol and atenolol was not related to the decrease in heart rate. Both propranolol and atenolol inhibited norepinephrine clearance by 12% to 16%. The 1 mg/kg doses of propranolol and atenolol significantly suppressed norepinephrine spillover rate by 21% and 32%, respectively, at 4 h postinjection. As the dose of propranolol was increased, the inhibition of norepinephrine spillover was reversed as plasma epinephrine concentration rose by 125%. The suppression of norepinephrine spillover rate caused by atenolol was more persistent but did diminish after the 10 mg/kg dose, when plasma epinephrine concentration was elevated by 55%. Both drugs suppressed plasma renin concentration, but the inhibition of norepinephrine spillover rate by propranolol and atenolol was not related to the fall in plasma renin concentration. By comparison, treatment with the adrenergic neuron blocking agent bretylium (5, 10, 20 and 40 mg/kg, s.c.) elicited a dose-related vasodepression with no change in heart rate or plasma renin concentration.(ABSTRACT TRUNCATED AT 250 WORDS)

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Propranolol and atenolol inhibit norepinephrine spillover rate into plasma in conscious spontaneously hypertensive rats

Keeton

Biediger

1991

Naunyn-Schmiedeberg's Arch Pharmacol

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Effects of acute and chronic treatments with atenolol and propranolol on cardiovascular responses to handling stress in spontaneously hypertensive rats.

Kudo¹,

Sokabe²,

Kawashima³

1983

Journal of Pharmacobio-Dynamics

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The ratio of cardiac to vascular .BETA.-receptor blockade of atenolol and propranolol in spontaneously hypertensive rats in vivo.

Cited by 2 publications

References 7 publications

Propranolol and atenolol inhibit norepinephrine spillover rate into plasma in conscious spontaneously hypertensive rats

Propranolol and atenolol inhibit norepinephrine spillover rate into plasma in conscious spontaneously hypertensive rats

Effects of acute and chronic treatments with atenolol and propranolol on cardiovascular responses to handling stress in spontaneously hypertensive rats.

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