Effects of acute and chronic treatments with atenolol and propranolol on cardiovascular responses to handling stress in spontaneously hypertensive rats.

Kudo, Yoshitaka; Sokabe, Hirofumi; Kawashima, Koichiro

doi:10.1248/bpb1978.6.729

Journal of Pharmacobio-Dynamics

1983

DOI: 10.1248/bpb1978.6.729

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Effects of acute and chronic treatments with atenolol and propranolol on cardiovascular responses to handling stress in spontaneously hypertensive rats.

Yoshitaka Kudo¹,

Hirofumi Sokabe²,

Koichiro Kawashima³

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Cited by 3 publications

References 18 publications

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Possible involvement of an impaired baroreflex mechanism but not the renin-angiotensin system and vasopressin in the enhanced pressor responsiveness to physostigmine in spontaneously hypertensive rats

Kawashima¹,

Miwa²,

Fujimoto³

1987

General Pharmacology: The Vascular System

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Effects of physostigmine on heart rate, mean arterial pressure (MAP), plasma renin concentration (PRC) and vasopressin (AVP) release were investigated in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. Physostigmine (100 micrograms/kg, i.a.) produced a greater and prolonged hypertensive response in the SHR than in the WKY. Heart rate was increased by physostigmine in SHR rats while it was unchanged in the WKY. PRC was unchanged or even slightly decreased in these animals when MAP was increased by physostigmine. An AVP pressor antagonist did not attenuate the pressor and cardiac effects of physostigmine in these animals. These data indicate that an impaired baroreflex mechanism or a different mode of sympathetic neuronal activation by physostigmine through the central mechanism appears to be contributory, at least in part, to the enhanced pressor responsiveness in the SHR. The renin-angiotensin system and AVP do not appear to be involved in the enhanced pressor responsiveness to physostigmine in SHR rats.

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Possible involvement of an impaired baroreflex mechanism but not the renin-angiotensin system and vasopressin in the enhanced pressor responsiveness to physostigmine in spontaneously hypertensive rats

Kawashima¹,

Miwa²,

Fujimoto³

1987

General Pharmacology: The Vascular System

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Endogenous corticotropin-releasing hormone inhibits conditioned-fear-induced vagal activation in the rat

Nijsen

Croiset

Diamant

et al. 2000

European Journal of Pharmacology

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Hypotensive Effect of Bunitrolol at Low Plasma Concentrations in Conscious, Unrestrained Spontaneously Hypertensive Rats

Kawashima

Miwa

Fujimoto

et al. 1985

Japanese Journal of Pharmacology

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Abstract-Effects of bunitrolol on mean arterial pressure (MAP) and heart rate (HR) were studied in conscious, unrestrained spontaneously hypertensive (SHR) rats at rest and during handling stress.Propranolol was employed as a reference drug.Plasma drug concentrations were determined to related with the cardio vascular effects of the drugs.Bunitrolol produced a tachycardia for the first 2 hr and a significant reduction in resting MAP at 3 and 4 hr after the oral dose (5 mg/kg) when plasma bunitrolol concentration was less than 10 ng/ml, indicating the difference between cardiac and vascular beta adrenoceptors in sensitivity to intrinsic sympathomimetic action or direct vasodilator action. Propranolol (5mg/kg) produced no discernible effects on resting MAP and HR. Stress-induced tachycardia was significantly inhibited by both drugs throughout the experiment, while significant inhibition of hypertensive response was observed only at 4 hr after the treatment. Both bunitrolol and propranolol were rapidly absorbed from the gastrointestinal tract. Plasma half-life of these drugs were almost the same values of around 2 hr. These results indicate that dose size, plasma concentrations, and procedures and the timing of blood pressure measurement are the important factors to be considered when the antihypertensive effect of beta-blockers is studied in SHR rats.

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Effects of acute and chronic treatments with atenolol and propranolol on cardiovascular responses to handling stress in spontaneously hypertensive rats.

Cited by 3 publications

References 18 publications

Possible involvement of an impaired baroreflex mechanism but not the renin-angiotensin system and vasopressin in the enhanced pressor responsiveness to physostigmine in spontaneously hypertensive rats

Possible involvement of an impaired baroreflex mechanism but not the renin-angiotensin system and vasopressin in the enhanced pressor responsiveness to physostigmine in spontaneously hypertensive rats

Endogenous corticotropin-releasing hormone inhibits conditioned-fear-induced vagal activation in the rat

Hypotensive Effect of Bunitrolol at Low Plasma Concentrations in Conscious, Unrestrained Spontaneously Hypertensive Rats

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