The ratio of alpha-calcitonin gene-related peptide to substance P is associated with the transition of bone metabolic states during aging and healing

Liu, Qianzi; Yu, Minxuan; Liao, Menglin; Ran, Zhiyue; Tang, Xiaofeng; Hu, Jun; Su, Beiju; Fu, Gang; Wu, Qingqing

doi:10.1007/s10735-023-10167-0

J Mol Histol

2023

DOI: 10.1007/s10735-023-10167-0

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The ratio of alpha-calcitonin gene-related peptide to substance P is associated with the transition of bone metabolic states during aging and healing

Qianzi Liu,

Minxuan Yu,

Menglin Liao

et al.

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2024

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Neuronal regulation of bone and tendon injury repair: a focused review

Xu,

Zhu,

Qin

et al. 2024

Journal of Bone and Mineral Research

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Beyond the sensation of pain, peripheral nerves have been shown to play crucial roles in tissue regeneration and repair. As a highly innervated organ, bone can recover from injury without scar formation, making it an interesting model in which to study the role of nerves in tissue regeneration. As a comparison, tendon is a musculoskeletal tissue that is hypo-innervated, with repair often resulting in scar formation. Here, we reviewed the significance of innervation in three stages of injury repair (inflammatory, reparative, and remodeling) in two commonly injured musculoskeletal tissues: bone and tendon. Based on this focused review, we conclude that peripheral innervation is essential for phases of proper bone and tendon repair, and that nerves may dynamically regulate the repair process through interactions with the injury microenvironment via a variety of neuropeptides or neurotransmitters. A deeper understanding of neuronal regulation of musculoskeletal repair, and the crosstalk between nerves and the musculoskeletal system, will enable the development of future therapies for tissue healing.

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Neuronal regulation of bone and tendon injury repair: a focused review

Xu,

Zhu,

Qin

et al. 2024

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

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The ratio of alpha-calcitonin gene-related peptide to substance P is associated with the transition of bone metabolic states during aging and healing

Cited by 1 publication

References 79 publications

Neuronal regulation of bone and tendon injury repair: a focused review

Neuronal regulation of bone and tendon injury repair: a focused review

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