The rapid growth of fibroids during early pregnancy

Benaglia, Laura; Cardellicchio, Lucia; Filippi, Francesca; Paffoni, Alessio; Leonardi, M.; Somigliana, Edgardo

doi:10.1016/j.fertnstert.2013.07.1002

Cited by 7 publications

(14 citation statements)

References 19 publications

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“…In our case, the patient underwent an ICSI procedure, which took place three years before the myomectomy. Fibroids' dramatic enlargement can be related to ICSI and pregnancy, as reported in the literature (14). Moreover, our patient took Cetrotide, a GnRH antagonist, which was not previously associated with uterine leiomyoma lymphoid infiltration, during the procedure.…”

Section: Discussionsupporting

confidence: 64%

Uterine leiomyoma with massive lymphoid infiltrate in a patient with history of assisted in-vitro fertilization

Prete¹,

Collamarini²,

Collamarini³

et al. 2019

TJPATH

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Uterine leiomyomas are the most common benign tumors of the gynecological tract. Massive lymphocytic infiltration has been reported rarely in uterine leiomyomas and it has been described as a pathogenetic correlation with gonadotropin-releasing hormone agonists. Uterine leiomyomas with massive lymphoid infiltration have to be differentiated from non-Hodgkin lymphomas. We report a case of a woman without a history of gonadotropin-releasing hormone agonist treatment, who presented with a uterine leiomyoma that increased in size after the procedure of assisted in-vitro fertilization, and associated with massive nodular lymphoid infiltrate simulating, morphologically, a non-Hodgkin lymphoma. Uterine leiomyoma with massive lymphocytic infiltration is a very rare entity, probably of reactive significance, which has to be differentiated from diseases that need a systemic therapeutic approach.

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Section: Discussionsupporting

confidence: 64%

Uterine leiomyoma with massive lymphoid infiltrate in a patient with history of assisted in-vitro fertilization

Prete¹,

Collamarini²,

Collamarini³

et al. 2019

TJPATH

View full text Add to dashboard Cite

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“…In the current study, fibroids ≤ 2 cm at first evaluation increased in size whereas fibroids that were ≥2 cm showed no change in size during the second trimester. Benaglia et al reported significant fibroid growth during early pregnancy and explained human chorionic gonadotropin as an important contributing factor [ 17 ]. Lev-Toaff et al described that fibroids either increased in size or remained unchanged, in response to increased estrogen in the first trimester, and in the second trimester, smaller fibroids (2–6 cm) increased in size or remained unchanged while larger fibroids (>6 cm) decreased in size, maybe due to the starting of estrogen receptor downregulation.…”

Section: Discussionmentioning

confidence: 99%

Does Uterine Fibroid Adversely Affect Obstetric Outcome of Pregnancy?

Saleh

Mowafy

Hameid

et al. 2018

BioMed Research International

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Background Fibroid is the most common benign tumor of the uterus and if associated with pregnancy may adversely affect the outcome of pregnancy. Objective of the present study was to assess the obstetric outcome (maternal and fetal) in pregnancy with fibroid. Methods A prospective observational study was performed over a period from May 2015 to August 2017 at Obstetrics and Gynecology Department in Zagazig University Hospitals, Egypt. 64 pregnant patients with >2 cm fibroid were taken in the study. Routine fundamental investigations were done for all. They were followed during antenatal period clinically and scanned by ultrasonogram which was done at booking visit and during subsequent visits to assess the change in the size of the fibroid and other obstetric complications. Maternal age, parity, size of fibroid, complications during pregnancy, and mode of delivery were noted. Results 64 pregnant patients with uterine fibroids were recruited; 47 of them completed the study to the end. The average age was 31.80 ± 3.27 years, body mass index (BMI) [calculated as weight in kilograms divided by the square of height in meters] was 24.67 ± 2.46, primigravida was 23.4%, multigravida was 76.6%, duration of menstrual cycle/day was 29.68 ± 3.10, and duration of menstrual period/day was 6.46 ± 1.12. The percentage of spontaneous conception was 59.57% and 40.43% for using assisted reproductive technology. The results of obstetric outcome were spontaneous abortion in 2%, premature delivery in 27.7%, and delivery at 37–41 weeks of pregnancy in 70.2%. The mode of delivery was vaginal delivery in 15% and cesarean sections in 85%. Also, 34% had threatened miscarriage, 21% had preterm labor, 2% had antepartum bleeding in the form of placenta previa, 4% had abdominal pain needing admission, one of them underwent laparotomy and was diagnosed as red degeneration, 2 (4%) had postpartum hemorrhage, and only one needed blood transfusion. Cesarean sections were done in 85%. Neonatal outcome was acceptable with no perinatal mortality. There were no significant differences between patients with single or multiple fibroids as regards the obstetric outcome or type of fibroid either intramural or subserosal. The obstetric outcomes were not significantly affected by the number, size, or type of fibroids. Conclusions Even most of fibroids in pregnancy are asymptomatic but may be associated with some complications affecting the course of pregnancy and labor. So, pregnancy has to be cautiously screened in the antenatal period, through regular follow-up, to detect any adverse obstetric complications and so improve the outcome.

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“…Changes in fibroids during pregnancy remain controversial. Benaglia et al [17] reported remarkable fibroid growth during initial pregnancy and described human chorionic gonadotropin as a significant factor that caused this. Lev-Toaff et al [18] reported that, in response to increased estrogen during the first trimester, fibroids either increased in size or remained unchanged.…”

Section: Discussionmentioning

confidence: 99%