The Radioprotective Effect of Bacterial Endotoxin

Behling, Ulrich H.

doi:10.1007/978-1-4684-4364-6_6

Cited by 31 publications

(6 citation statements)

References 67 publications

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“…Many compounds have been found to protect from radiation death when injected shortly before irradiation. [133][134][135][136][137][138][139] These substances include: sulfhydrylcontaining molecules, fat emulsions, amines, biological polymers, thiol compounds, BCG, muramyl dipeptide, glucan, bacterial lipopolysaccharide ͑LPS͒, cytokines and other growth factors such as interleukin 1 ͑IL-1͒, human recombinant ͑hur͒ IL-1␤, and tumor necrosis factor TNF␣. A synthetic 163-171 nonopeptide of human interleukin 1␤ protected mice from lethal radiation injury and restored viability ͑Freska et al 140 ͒.…”

Section: ͒mentioning

confidence: 99%

Pathophysiological effects of radiation on atherosclerosis development and progression, and the incidence of cardiovascular complications

2002

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Radiation therapy while important in the management of several diseases, is implicated in the causation of atherosclerosis and other cardiovascular complications. Cancer and atherosclerosis go through the same stages of initiation, promotion, and complication, beginning with a mutation in a single cell. Clinical observations before the 1960s lead to the belief that the heart is relatively resistant to the doses of radiation used in radiotherapy. Subsequently, it was discovered that the heart is sensitive to radiation and many cardiac structures may be damaged by radiation exposure. A significantly higher risk of death due to ischemic heart disease has been reported for patients treated with radiation for Hodgkin's disease and breast cancer. Certain cytokines and growth factors, such as TGF-beta1 and IL-1 beta, may stimulate radiation-induced endothelial proliferation, fibroblast proliferation, collagen deposition, and fibrosis leading to advanced lesions of atherosclerosis. The treatment for radiation-induced ischemic heart disease includes conventional pharmacological therapy, balloon angioplasty, and bypass surgery. Endovascular irradiation has been shown to be effective in reducing restenosis-like response to balloon-catheter injury in animal models. Caution must be exercised when radiation therapy is combined with doxorubicin because there appears to be a synergistic toxic effect on the myocardium. Damage to endothelial cells is a central event in the pathogenesis of damage to the coronary arteries. Certain growth factors that interfere with the apoptotic pathway may provide new therapeutic strategies for reducing the risk of radiation-induced damage to the heart. Exposure to low level occupational or environmental radiation appears to pose no undue risk of atherosclerosis development or cardiovascular mortality. But, other radiation-induced processes such as the bystander effects, abscopal effects, hormesis, and individual variations in radiosensitivity may be important in certain circumstances.

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Section: ͒mentioning

confidence: 99%

Pathophysiological effects of radiation on atherosclerosis development and progression, and the incidence of cardiovascular complications

2002

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“…Mice pretreated with IL-1 followed by the adminis tration of sublethal dose of irradiation may be res cued from the otherwise lethal effect of irradiation on the bone marrow [61][62][63][64]. A single dose of 200 ng of IL-la was radioprotective when administered 20 or 4 h before irradiation [64].…”

Section: Radioprotectionmentioning

confidence: 99%

The Role of Interleukin-1 in Hematopoiesis

Fibbe¹,

Willemze²

1991

Acta Haematol

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The polypeptide interleukin 1 (IL-1) is the primary mediator of the acute-phase response and is responsible for many changes that are associated with the onset of infection. It induces fever and has profound endocrinologic metabolic and hematologic effects. Two structurally related forms of IL-1 have been described, termed IL-1α and IL-1β. Both forms of IL-1 bind to a common receptor that is present on a variety of target cells. Recently, IL-1 has been recognized as a molecule that is important in the regulation of hematopoiesis. IL-1 induces the production of several different hematopoietic growth factors including granulocyte-macro-phage, granulocyte and macrophage colony-stimulating factors and interleukin 6 by a variety of accessory cells. In addition, IL-1 acts synergistically with colony-stimulating factors in the proliferation of primitive hematopoietic progenitor cells. In vivo, the administration of IL-1 accelerates hematopoietic reconstitution after chemotherapy or radiation induced myelosuppression. In untreated animals, IL-1 may induce a shift of hematopoietic progenitor cells into the peripheral blood, and these cells may be used to repopulate the bone marrow of lethally irradiated recipients. These studies suggest that IL-1 may be used as a therapeutic agent to accelerate bone marrow recovery after myelosuppression.

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“…We know that specific inflammations or bacterial infections induce direct effects on the haematopoietic tissue, which involve namely ILI and endotoxins . In particular, the radioprotective effect conferred by immunomodulatory bacterial endotoxins (Behling 1983) should be mediated by haematopoiesis stimulation . Staber et al .…”

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confidence: 99%

Radioprotective Effect of an Acute Non-specific Inflammation in Mice

Hérodin

Laval

Fatome

et al. 1987

International Journal of Radiation Biology and Related Studies

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Protection against 8.7 Gy whole-body gamma-irradiation (lethal in 100 per cent of mice by 30 days) was observed in 90 per cent of mice bearing a one-day-old granuloma induced by polyacrylamide beads. When the inflammatory reaction was induced sooner or later a lower or null protection was obtained. A dose-effect relationship between the volume of injected beads and resulting radioprotection was established. The radioprotective effect depends only on the acute non-specific inflammation since hydrocortisone acetate injected into mice before the beads abolished this protection. This inflammatory pattern led to a dose reduction factor of 1.36 +/- 0.08 (P less than 0.05) for LD 50/30. A 90 per cent survival was observed in mice bearing a one-day-old granuloma when they were injected 1 h before 10 Gy with the granuloma acellular eluate (P less than 0.02 compared to a 50 per cent survival observed with polyacrylamide beads alone). Substances with a molecular weight higher than 300,000 are involved in the synergistic radioprotective effect of the granuloma-eluate association.

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The Radioprotective Effect of Bacterial Endotoxin

Cited by 31 publications

References 67 publications

Pathophysiological effects of radiation on atherosclerosis development and progression, and the incidence of cardiovascular complications

Pathophysiological effects of radiation on atherosclerosis development and progression, and the incidence of cardiovascular complications

The Role of Interleukin-1 in Hematopoiesis

Radioprotective Effect of an Acute Non-specific Inflammation in Mice

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