Radioprotective Effect of an Acute Non-specific Inflammation in Mice

Abstract

Protection against 8.7 Gy whole-body gamma-irradiation (lethal in 100 per cent of mice by 30 days) was observed in 90 per cent of mice bearing a one-day-old granuloma induced by polyacrylamide beads. When the inflammatory reaction was induced sooner or later a lower or null protection was obtained. A dose-effect relationship between the volume of injected beads and resulting radioprotection was established. The radioprotective effect depends only on the acute non-specific inflammation since hydrocortisone acetate injected into mice before the beads abolished this protection. This inflammatory pattern led to a dose reduction factor of 1.36 +/- 0.08 (P less than 0.05) for LD 50/30. A 90 per cent survival was observed in mice bearing a one-day-old granuloma when they were injected 1 h before 10 Gy with the granuloma acellular eluate (P less than 0.02 compared to a 50 per cent survival observed with polyacrylamide beads alone). Substances with a molecular weight higher than 300,000 are involved in the synergistic radioprotective effect of the granuloma-eluate association.

Protective effect of transparent film dressing on proton therapy induced skin reactions

“…Finally, it is possible that the adhesive could have radioprotective properties. This could occur from direct antioxidant effects that have been observed for topically applied oils and oil derived substances or indirectly through stimulation of mild, acute non-specific local inflammation that has been demonstrated to provide radioprotection through unclear mechanisms [8]. …”