Induction of acute phase proteins in mice and humans by treatment with AS101, an immunomodulator with radioprotective properties

Kalechman, Yona; Shani, Adi; Albeck, Michael; Sredni, Benjamin

doi:10.1016/0162-3109(94)00054-j

Cited by 8 publications

(2 citation statements)

References 21 publications

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“…The rise in the level of SAA in blood is the most intense and rapid among all acute phase proteins, SAA concentrations increasing by up to 1000-fold the normal physiological level [10,21]. SAA has been found to be a sensitive indicator of inflammation and valuable in monitoring the efficacy of antimicrobial and anti-inflammatory therapy [11,21,22].…”

Section: Introductionmentioning

confidence: 99%

The serum amyloid A response to sterile silver nitrate in mice and its inhibition by dexamethasone and macrolide antibiotics

Glojnarić

Čužić

Eraković-Haber

et al. 2007

International Immunopharmacology

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Section: Introductionmentioning

confidence: 99%

The serum amyloid A response to sterile silver nitrate in mice and its inhibition by dexamethasone and macrolide antibiotics

Glojnarić

Čužić

Eraković-Haber

et al. 2007

International Immunopharmacology

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“…Immunomodulators are another class of radioprotectors that can enhance the proportion of hematopoietic stem cells into more radio-resistant phase of the cell cycle or increase of the size of the post-irradiation stem cell population. 27,28 Various studies and clinical trials have been done regarding the protective efficacy of various compounds like L-Carnitine which prevents the formation of free radicals by xanthine-xanthine oxidase system, 29 Palifermin-recombinant human keratinocyte growth factors, 30 herbal products like black seed (Nigella Sativa oil), 31 multiple ex-vivo studies conclude that the suppression of bone marrow hematopoietic activity post radiation therapy is mitigated significantly with ON0121.Na, 32 wheat germ-oil etc., 33 but Amifostine (WR1065) remains one of the most promising drug in clinical use presently because of its dual action nature as a free radical scavenger and in repair reaction of DNA damage 26 and is safe and practical to administer in a clinical setting.…”

Section: Other Compoundsmentioning

confidence: 99%

A role of radioprotective agents in cancer therapeutics: a review

Velpula

Ugrappa

Kodangal

2013

Int J Basic Clin Pharmacol

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In the field of medicine or dentistry, cancer is one of the most common causes for death of the individual worldwide, in which oral cancer accounts for about 10% of it. One of the most important treatment modalities for cancer includes radiotherapy. During radiotherapy, exposure of the normal tissue to these ionizing radiations, results in mutagenesis and cell death. Several modalities and clinical approaches have been made to reduce these early and late complications of the radiotherapies and one among them is, by the means of pharmacological agents. Many experimental and clinical studies have given rise to new concepts of chemical and molecular pharmacological agents that could be effective in protection and treatment of radiation damage to surrounding normal tissues. Clinical Significance:To reduce the significant complications in irradiated patients, the clinical implication of these radioprotective agents have emerged as potential drugs and with anti-tumour effect in the radiotherapy of various cancers including oral carcinomas.

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Radioprotection by plant products: present status and future prospects

Arora

Gupta

Chawla

et al. 2005

Phytotherapy Research

296

188

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The development of radioprotective agents has been the subject of intense research in view of their potential for use within a radiation environment, such as space exploration, radiotherapy and even nuclear war. However, no ideal, safe synthetic radioprotectors are available to date, so the search for alternative sources, including plants, has been on going for several decades. In Ayurveda, the traditional Indian system of medicine, several plants have been used to treat free radical-mediated ailments and, therefore, it is logical to expect that such plants may also render some protection against radiation damage. A systematic screening approach can provide leads to identifying potential new candidate drugs from plant sources, for mitigation of radiation injury. This article reviews some of the most promising plants, and their bioactive principles, that are widely used in traditional systems of medicine, and which have rendered significant radioprotection in both in vitro and in vivo model systems. Plants and their constituents with pharmacological activities that may be relevant to amelioration of radiation-mediated damage, including antiemetic, antiinflammatory, antioxidant, cell proliferative, wound healing and haemopoietic stimulatories are also discussed.

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Induction of acute phase proteins in mice and humans by treatment with AS101, an immunomodulator with radioprotective properties

Cited by 8 publications

References 21 publications

The serum amyloid A response to sterile silver nitrate in mice and its inhibition by dexamethasone and macrolide antibiotics

The serum amyloid A response to sterile silver nitrate in mice and its inhibition by dexamethasone and macrolide antibiotics

A role of radioprotective agents in cancer therapeutics: a review

Radioprotection by plant products: present status and future prospects

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