Radioprotection by plant products: present status and future prospects

Arora, Rajesh; Gupta, Damodar; Chawla, Raman; Sagar, Ravinder Kumar; Sharma, Ashok; Kumar, Raj; Prasad, Jagdish; Singh, Surinder; Samanta, Namita; Sharma, Rakesh

doi:10.1002/ptr.1605

Cited by 287 publications

(193 citation statements)

References 255 publications

(228 reference statements)

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“…Echinacea owes its powerful radioprotective effects to the scavenging capacity of phenolic compounds caffeic acid, cichoric acid, and echinacoside. Earlier findings of the benefi cial effects of natural phenolic compounds have shown that they possess stronger antioxidant capacity than vitamins (13). The radioprotective properties of medicinal plants such as Podophyllum hexandrum, Ocimum sanctum, Ginko biloba, and Mentha piperita have been attributed to the presence of polyphenols capable to stop propagation steps of lipid peroxidation and chelate transitional metal ions, and hence to inhibit free radical formation (14).…”

Section: Discussionmentioning

confidence: 99%

Biological Effects of Echinacea Purpurea on Human Blood Cells

Joksić

Petrović

Joksić³

et al. 2009

Archives of Industrial Hygiene and Toxicology

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Biological Effects of Echinacea Purpurea on Human Blood CellsThe aim of this study was to investigate radioprotective properties of Echinacea purpurea tablets in vivo. We analysed lymphocyte chromosome aberrations (CA), micronuclei (MN), apoptosis of leukocytes and haematological parameters in a group of radiation workers who were identified as carrying dicentric chromosomes in their lymphocytes. All radiation workers were taking two 275 mg Echinacea tablets b.i.d., according to a pharmacist's recommendation. All parameters were analysed before and after the two-week treatment. At the end of the treatment lymphocyte CA frequency dropped significantly, and the number of apoptotic cells increased. The inverse lymphocyte-to-granulocyte ratio at the beginning of the study changed to normal at its end. In conclusion, biological effects observed after administration of Echinacea purpurea preparation suggest that it may be beneficial for the prevention of adverse health effects in workers exposed to ionising radiation.

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Section: Discussionmentioning

confidence: 99%

Biological Effects of Echinacea Purpurea on Human Blood Cells

Joksić

Petrović

Joksić³

et al. 2009

Archives of Industrial Hygiene and Toxicology

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“…When we consume fruit and vegetables we take in more than vitamins. The phenolic compounds and vitamins in plants, antioxidant substances [11,12], appear to give fruit, vegetables, herbs and condiments properties preventing serious chronic diseases and metabolic syndromes such as: cancers, cardiovascular disorders, neurodegenerative diseases, osteoporosis, diabetes, hypercholesterolemia and cell ageing [3,[13][14][15][16][17]. To understand the protective role of phenolic compounds, we need to track their progress in the body.…”

Section: Biodiversity Dietary Intakementioning

confidence: 99%

Harnessing the health benefits of plant biodiversity originating from the American tropics in the diet

Fahrasmane¹,

Ganou²,

Aurore³

2007

Fruits

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--Introduction. Fruit and vegetable consumption is now more than ever before understood, along with physical exercise, to be among the factors ensuring well-being. Crosscultural epidemiological studies reveal a preventive effect of this consumption on certain human pathologies, whence the emergence of preventive nutrition. Changes in biodiversity dietary intake. Industrially-processed products, undergoing a greater or lesser degree of refinement, were developed during the last century; they focused on a few productive species and varieties. The concept of high-calorie foods, an energy source, which has been prevalent in dietetics over the past few decades, had minimised the role of fruit and vegetables in the diet, due to their low calorie content. Plant biodiversity in foodstuffs originating from the American tropics. There are few cultivated major species and varieties in terms of biodiversity. 40% of the edible plant species in the world today originate from the American tropics. Of the planet's 250 000 estimated plant species, 100 000 are believed to be from the Americas. Preserving the beneficial properties of processed products. To improve recovery of the properties of the fresh resource for the consumer, innovation in the processing methods is required, with unit operations ensuring the best possible preservation of the healthy compounds. Conclusion and prospects. Communication on fruit and vegetables has not enjoyed the same research and publicity resources as many processed products. Knowledge of and information on food resources, diet and health have become a major challenge. The relative wealth of the plant biodiversity from the American tropics represents a heritage we need to reharness. Résumé --Introduction. La consommation de fruits et légumes est plus que jamais appré-hendée, avec l'exercice physique, comme l'un des garants du bien être. Des études épidémio-logiques transculturelles laissent apparaître un effet préventif de cette consommation sur certaines pathologies humaines, d'où l'éclosion de la nutrition préventive. Évolution de l'appropriation alimentaire de la biodiversité. Des produits transformés industrialisés, plus ou moins raffinés, ont été développés au cours du dernier siècle ; ils ont été focalisés sur quelques espèces et variétés productives. Le concept d'aliment calorique, source d'énergie, qui a pré-valu dans la diététique ces dernières décennies, avait minimisé la place des fruits et légumes dans l'alimentation, du fait de leur faible apport calorique. La biodiversité végétale alimentaire originaire d'Amérique tropicale. Les espèces et variétés majeures cultivées sont peu nombreuses, au regard de la biodiversité. Aujourd'hui, 40 % des espèces végétales alimentaires dans le monde sont originaires d'Amérique tropicale. Parmi les 250 000 espèces végétales estimées de la planète, 100 000 seraient américaines. Préserver les propriétés bénéfiques des produits transformés. Pour permettre une meilleure restitution, au consommateur, des propriétés de la ressource fraîche, il fa...

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“…To date, synthetic radio-protectors, such as amino thiol or S-2-(3-aminopropyl-amino) ethyl phosphorothioic acid, have not shown to be promising compounds for clinical use because of their high toxicity at effective concentrations (4,5). Less-or non-toxic natural products with free radical scavenging, antioxidant activities, and immune stimulatory effects have advantages over their synthetic counterparts (4).…”

Section: Introductionmentioning

confidence: 99%

“…Less-or non-toxic natural products with free radical scavenging, antioxidant activities, and immune stimulatory effects have advantages over their synthetic counterparts (4). A number of dietary antioxidants have been reported to decrease the harmful effect of free radicals on biomolecules (6).…”

Section: Introductionmentioning

confidence: 99%

In vivo Time-Dependent Radio-Protective Effect of Lycopene Against Whole-Body Gamma Radiation in Mice

Oladi

Sazgarnia

Nasiri

et al. 2016

Iran Red Crescent Med J

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Background: Ionizing radiation has become an essential part of modern medicine. However, applying the effective dose of ionizing radiation is compromised by its inevitable radiation-induced damage to normal tissues. Natural products with free radical scavenging, antioxidant activities, and immune stimulatory effects offer suitable radio-protective effects. Objectives: This study was designed to evaluate the in vivo radio-protective activity of lycopene, a naturally dietary carotenoid, against whole-body gamma-irradiation-induced mortality and sickness in mice. Methods: In this animal experimental study, lycopene was extracted from tomato paste, characterized, and then administered to mice. Consecutively, 80 healthy adult male mice were recruited and irradiated individually, and then monitored for irradiation sickness and survival parameters. Results: Pretreatment with 7 mg/kg dose of lycopene 7 days before irradiation was found to reduce the severity of symptoms of radiation sickness in a 30-day post-radiation monitoring. Lycopene treatment increased the survival rate. At the radiation dosage of 8 and 9 Gy, the difference between the survival rates of control and sample groups became significant after day 15 and 25. Lycopene was also shown to have a protective effect on white blood cell count against 8 and 9 Gy gamma radiations. Conclusions: Natural and exhibiting whole-body radio-protective activity, lycopene can be proposed as an effective radio-protector in healthy people who are exposed to radiation, such as radiographers, nuclear pharmacists, and radiologists.

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Radioprotection by plant products: present status and future prospects

Cited by 287 publications

References 255 publications

Biological Effects of Echinacea Purpurea on Human Blood Cells

Biological Effects of Echinacea Purpurea on Human Blood Cells

Harnessing the health benefits of plant biodiversity originating from the American tropics in the diet

In vivo Time-Dependent Radio-Protective Effect of Lycopene Against Whole-Body Gamma Radiation in Mice

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