The Radioprotective and Anticancer Effects of Banana Peels Extract on Male Mice

Abstract

This study was performed to evaluate the radioprotective and anticancer effect of banana peels extract on male mice. Sixty male mice weighted 18-25 gm were used, the animals divided equally into six groups as follow first group act as normal , second group (Tumor control) implanted with Ehrlich tumor, third group ,irradiated group exposed to single dose of 3.0 GY of gamma rays, fourth group (banana peels extract 300 mg/kg/day orally for 3weeks, fifth group (tumor implanted + banana peels extract 300 mg/kg/day orally for 3weeks, sixth group (irradiated with dose 3.0 GY gamma+ 300 mg/kg/day for 3 weeks). At the end of experiment mice were sacrificed by anesthesia and the blood were collected to evaluate biochemical parameters (Complete Blood Count (CBC), Carcino embryonic antigen,(CEA), Malonaldehyde (MDA), Molecular study, electrophoretic assayed. The results showed that banana peels extract ameliorate the alteration in CBC in irradiated and tumor group, and significantly decrease p≤0.05 the elevation of Carcino embryonic antigen in tumor implanted group, significantly decrease the elevation of Malonaldehyde in tumor implanted group and irradiated group. According to protein fractions and western blotting data it could be concluded that, addition banana peels extract consider a crucial impact for Irradiation dose which cleared through huge increase of Polymorphism % for addition banana peels extract (20%) comparing with to Irradiation treatment which didn't reflect polymorphism. Furthermore, noticeable stimulation for P53 expression level was detected for applying banana peels extract and Irradiation as Compound dosage.

Antioxidant activity of banana flesh and antiproliferative effect on breast and pancreatic cancer cells

“…( 2015 ) found that HE of a Malaysian variety of banana fruit flesh had growth inhibitory effects on MCF‐7 estrogen receptor‐positive breast cancer cells. Kamal et al ( 2019 ) have shown anticancer and radioprotective effects of banana peel extracts in‐vivo.…”

Banana Peel: A potential waste product with numerous pharmacological activities

“…95% ethanolic extract of air-dried peel powder [19] Complete blood count, Carcino embryogenic antigen, Malondialdehyde Possess anticancer agents by improving hematological parameters, inhibiting carcino embryonic antigen and malonaldehyde.…”

“…Research is being carried out for anticancer agents which can minimize the limitations of existing drugs [18]. Amal MK, et al, [19] studied antitumor activity of 95% ethanolic extract of air-dried banana peel powder. The study was conducted male Swiss mice.…”

“…Amaal MK, et al, [19] studied the radioprotective effect of 95% ethanol extract of air-dried powder of banana peel using male mice. A noticeable stimulation for P53 expression level was detected for applying banana peels extract and irradiation as compound dosage.…”

Control of carbendazim toxicity using banana peel powder in rats

“…Also, Kamal et al . [ 43 ] reported that the banana peels extract had anti-cancer agents, radioprotective, improving hematological parameters and attenuated lipid peroxidation of mice.

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