The radiolytic studies of panipenem in the solid state

Rosiak, Natalia; Cielecka‐Piontek, Judyta; Kilińska, Karolina; Skibiński, Robert; Szymanowska, Daria; Miklaszewski, Andrzej; Lewandowska, Kornelia; Piekara-Sady, L.; Tykarska, Ewa; Zalewski, Przemysław

doi:10.32383/appdr/117889

Cited by 4 publications

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“…The application of a very high radiation dose (400kGy) allowed for understanding physicochemical changes taking place in the molecule, identifying the degradation products, and linking them to changes in the bactericidal properties of ERP. It also confirms the need to conduct research for each molecule separately due to its individual response to radiation in comparison with compounds from the same group of drugs [9,10,11].…”

Section: Discussionsupporting

confidence: 55%

“…Previous research concerning the radiostability of β-lactams antibiotics have confirmed their susceptibility to degradation [7,8,9,10,11,12,13]. Test results—both identification methods and stability tests—carried out for solid ERP reflect this statement.…”

Section: Discussionmentioning

confidence: 62%

“…For this reason, it is particularly important to choose the suitable sterilization method for ERP and irradiation seems to be the most advantageous approach. However, the use of this method requires detailed studies and confirmation of the impact of irradiation on the pharmaceutical properties and structure of the drug [7,8,9,10,11,12,13].…”

Section: Introductionmentioning

confidence: 99%

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The Radiation Sterilization of Ertapenem Sodium in the Solid State

et al. 2019

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For the first time, the influence of ionising radiation on the physicochemical properties of ertapenem in solid state was studied. During our studies, we evaluated the possibility of applying radiosterilization to obtain sterile ertapenem. Spectroscopic (Fourier Transform Infrared (FT-IR)), thermal (differential scanning calorimetry (DSC), chromatography (High-Performance Liquid Chromatography (HPLC) and HPLC-MS), and X-ray powder diffraction (XRPD) studies shown that irradiation of ertapenem with the 25 kGy, the dose required to achieve sterility, does not change the physicochemical properties of the studied compound. The antimicrobial activity of ertapenem irradiated with the dose of 25 kGy was only reduced for one species. Based on the received results, we can conclude that radiostelization is a promising alternative method of obtaining sterile ertapenem. In our studies, ertapenem was also exposed to e-beam radiation with a dose of 400 kGy. It was determined that two novel degradation products that are structurally differently to degradants formed during hydrolysis and thermolysis.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 62%

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The Radiation Sterilization of Ertapenem Sodium in the Solid State

et al. 2019

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“…The first studies were focused on confirming the effectiveness and advantages of irradiation as a method of sterilization and establishing a standard dose for this process [ 1 , 2 , 3 , 4 , 5 , 6 ]. Whereas the majority of currently conducted research is aimed at verifying the possibility of using radiation for a specific type of drug-effect of this method on the physicochemical properties of the compound while maintaining an adequate level of the sterility [ 7 , 8 , 9 , 10 , 11 ]. The foundations for such a verification are radiolitic studies based on the use of high doses of ionising radiation and a number of advanced analytical methods to understand the process of potential changes in stability of the drug and identification of radiolysis products [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Radiostability of Meropenem Trihydrate in Solid State

et al. 2018

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The influence of ionising radiation on the physicochemical properties of meropenem trihydrate in solid state was studied for doses of e-beam radiation: 25 kGy and 400 kGy. In the first part of our studies, we evaluated the possibility of applying radiosterilization to obtain sterile meropenem. No changes for meropenem irradiated with a dose of 25 kGy, the dose required to attain sterility, was confirmed in the results of spectroscopic (FT-IR), thermal (DSC, TGA) and X-ray powder diffraction (XRPD) studies. The radiation dose of 25 kGy produces no more than about 1500 ppm of radical defects. The chromatographic studies of irradiated meropenem in solutions did not show any chemical degradation. Moreover, the antimicrobial activity of meropenem irradiated with the dose of 25 kGy was unchanged. Based on the received results, we can conclude that radiostelization is a promising, alternative method for obtaining sterile meropenem. In the second part of the research, meropenem was exposed to e-beam radiation at the 400 kGy dose rate. It was confirmed, that reducing of antimicrobial activity could be connected with the degradation of β-lactam ring and changes in the trans-hydroxyethyl group. Apart from chemical changes, changes in the physical stability of irradiated meropenem (400 kGy) was also observed.

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“…The literature reports on the chemical instability of many compounds of natural and synthetic origin after exposure to ionizing radiation [ 17 , 18 , 19 , 20 ]. There is also evidence that many substances are resistant to ionizing radiation [ 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Potential of Resveratrol as the Result of Radiation Exposition

et al. 2022

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The purpose of this study was to determine the effect of electron beam irradiation (EBI) at a dose of 25 kGy on the stability and antioxidant properties of resveratrol (RSV), a nutraceutical with clinically proven activity. The electron paramagnetic resonance (EPR) method was used to evaluate the concentration of free radicals after irradiation. Minor changes in chemical structure due to free radicals induced by EBI were confirmed by FTIR spectroscopy. HPLC and HPLC-MS analysis ruled out the appearance of degradation products after irradiation. In addition, HPLC analysis confirmed the absence of trans- to cis-resveratrol conversion. Changes in the antioxidant potential of RSV after irradiation were studied using DPPH, ABTS, CUPRAC, and FRAP techniques. It was confirmed that EBI favorably affected the antioxidant properties of tests based on the HAT mechanism (increase in DPPH and CUPRAC tests).

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The radiolytic studies of panipenem in the solid state

Cited by 4 publications

References 0 publications

The Radiation Sterilization of Ertapenem Sodium in the Solid State

The Radiation Sterilization of Ertapenem Sodium in the Solid State

The Radiostability of Meropenem Trihydrate in Solid State

Antioxidant Potential of Resveratrol as the Result of Radiation Exposition

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