The radiological spectrum of pulmonary lymphoproliferative disease

Hare, S.S.; Souza, Carolina A.; Bain, Gillian; Seely, Jean M.; Frcpc,; Gomes, Marcio M.; Quigley, Maureen

doi:10.1259/bjr/16420165

Cited by 173 publications

(246 citation statements)

References 48 publications

Supporting

Mentioning

239

Contrasting

Unclassified

Order By: Relevance

“…The disease may also manifest differently by affecting various areas of the body, including the lungs, the alveolar septum and the pleural area, identified by imaging analysis (24). The pathological changes commonly observed inside the lungs predominantly affect the pulmonary interstitium and bronchial submucosal tissues, in addition to the bronchial wall (primarily the extra-wall pulmonary interstitium, such that the bronchial lumen remains unobstructed or experiences only slight stenosis) (25). Bronchial submucosal lymphoma involvement may form inner lumen nodular protrusions, or its growth around the bronchial wall may result in limited or extensive bronchial lumen narrowing, or even complete luminal obstruction complicated by pulmonary consolidation and atelectasis (25).…”

Section: Discussionmentioning

confidence: 99%

“…The pathological changes commonly observed inside the lungs predominantly affect the pulmonary interstitium and bronchial submucosal tissues, in addition to the bronchial wall (primarily the extra-wall pulmonary interstitium, such that the bronchial lumen remains unobstructed or experiences only slight stenosis) (25). Bronchial submucosal lymphoma involvement may form inner lumen nodular protrusions, or its growth around the bronchial wall may result in limited or extensive bronchial lumen narrowing, or even complete luminal obstruction complicated by pulmonary consolidation and atelectasis (25). When the alveolar septum is affected, the pulmonary septum initially thickens and, as the disease progresses, the alveolar space gradually becomes smaller or completely obstructed (25).…”

Section: Discussionmentioning

confidence: 99%

“…Bronchial submucosal lymphoma involvement may form inner lumen nodular protrusions, or its growth around the bronchial wall may result in limited or extensive bronchial lumen narrowing, or even complete luminal obstruction complicated by pulmonary consolidation and atelectasis (25). When the alveolar septum is affected, the pulmonary septum initially thickens and, as the disease progresses, the alveolar space gradually becomes smaller or completely obstructed (25). The invasions of the pleura is manifested as pleural thickening, patchy infiltrates or nodules, which tend to be distributed with a lack of aggregation (25).…”

Section: Discussionmentioning

confidence: 99%

“…When the alveolar septum is affected, the pulmonary septum initially thickens and, as the disease progresses, the alveolar space gradually becomes smaller or completely obstructed (25). The invasions of the pleura is manifested as pleural thickening, patchy infiltrates or nodules, which tend to be distributed with a lack of aggregation (25).…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Peripheral T-cell lymphoma unspecified type presenting with a pneumothorax as the initial manifestation: A case report and literature review

Yang

Zhang

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. The present study describes the case of a 51-year-old male presenting with a pneumothorax, in whom a final diagnosis of peripheral T-cell lymphoma unspecified type (PTCL-u) was determined. As the patient had experienced a shortness of breath subsequent to exercise for a period of 2 months, a fiber bronchoscopy was performed; however, no abnormalities were initially identified. Following the bronchoscopy, the patient suffered a recurrent pneumothorax with symptoms of emaciation, night sweats and a fever. The combination of computed tomography and interstitial lung pathology results suggested a high probability of malignant lymphoma. Further test results confirmed this diagnosis, including the fiber bronchoscopy biopsy report, which indicated a large amount of lymphocyte aggregation, and an ultrasound that identified several supraclavicular and left submandibular enlarged lymph nodes (largest size, 2.3x1.3 cm), with an absent hilar lymph node. A biopsy of the left cervical lymph node was performed, with post-operative pathological analysis confirming a diagnosis of peripheral T-cell lymphoma unspecified (stage IVB). The patient received two cycles of CHOP chemotherapy, and the symptoms alleviated following completion of the treatment, with chest radiography indicating that the pneumothorax had disappeared. The patient subsequently refused further treatment due to financial difficulty, and succumbed to the disease 6 months later.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Peripheral T-cell lymphoma unspecified type presenting with a pneumothorax as the initial manifestation: A case report and literature review

Yang

Zhang

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

show abstract

“…Pulmonary nodules are the most common findings on computed tomography images ( fig. 1), along with bronchovascular distribution [49,50]. In ,30% of patients, pleural effusion is present at the beginning and hilar adenopathies are found in ,25% of cases (table 3).…”

Section: Specific Entitiesmentioning

confidence: 99%

Lymphoproliferative lung disorders: clinicopathological aspects

Poletti¹,

Ravaglia²,

Tomassetti³

et al. 2013

European Respiratory Review

View full text Add to dashboard Cite

Lymphoproliferative disorders are rarely observed as primary lesions in the lung, representing only 0.3% of all primary pulmonary malignancies, ,1% of all the cases of non-Hodgkin lymphoma and 3-4% of all the extra nodal manifestations of non-Hodgkin lymphoma. The earliest comprehensive studies of pulmonary lymphomas were those of SALTZSTEIN [1] and PAPIOANNOU and WATSON [2], which were published in the 1960s. These investigators made important observations: low-grade neoplasms were more frequent than higher grade lymphomas (reticulum cell sarcomas) and both tumours had better clinical outcomes than their nodal-based counterparts. The authors also concluded that the majority of neoplasms with a low-grade cytological appearance should be considered as reactive proliferations, introducing the term ''pseudolymphoma''. This hypothesis showed significant weak points and, approximately 20 years later, ADDIS et al. [3] concluded that ''most if not all the cases of pseudo-lymphoma can be classified, when re-evaluated, as malignant lymphoma''. Knowledge of these entities expanded rapidly after the advent of new investigative tools such as immunohistochemistry and molecular biology techniques. The World Health Organization (WHO) classification of lymphoid neoplasm recently emphasised the importance of clinical features [4]. Table 1 provides an overall classification of lymphoproliferative disorders, which are described as: reactive/nonneoplastic lymphoid lesions, malignant parenchymal lymphoproliferative lesions (primary or secondary) and post-transplant lymphoproliferative disorders. Pathological aspectsReactive pulmonary lymphoid diseases Three rare forms of benign hyperplasia of pulmonary lymphoid tissue, namely follicular bronchiolitis, pulmonary nodular lymphoid hyperplasia and lymphocytic interstitial pneumonia, are regarded as part of the spectrum of lymphoid hyperplasia of the bronchus-associated lymphoid tissue (table 1) [5,6]. Follicular bronchiolitis is characterised by lymphoid follicular hyperplasia, often with reactive germinal centres, in the walls of bronchioles with narrowing of the lumen. Pulmonary nodular lymphoid hyperplasia (pulmonary pseudo-lymphoma) is a distinct form of reactive lymphoid proliferation with links to the family of IgG4-related sclerosing diseases, characterised by a dense nodular infiltration of mature, polyclonal lymphocytes and plasma cells, which are well-circumscribed and mainly sub-pleural, with some dense fibrosis between

show abstract

Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis

Chen

et al. 2022

Aging and Cancer

View full text Add to dashboard Cite

Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and represents a heterogeneous entity. One‐third of DLBCL arises from extranodal organs and its prognosis often varies with regard to the sites involved. Molecular features are important to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Extranodal DLBCLs originated from the breast, skin, uterus, immune‐privileged sites such as the central nervous system and testes, often show a high proportion of non‐germinal center B‐cell‐like (non‐GCB) phenotypes, with a high frequency of MYD88/CD79B mutations. In contrast, extranodal DLBCLs originated from the thyroid gland and stomach show a relatively low proportion of non‐GCB phenotype, with a considerably excellent prognosis. Immunochemotherapy with rituximab is the standard of care in both nodal and extranodal DLBCLs. However, approximately 40% of the patients experience treatment failure. It is critical to optimize the treatment strategy, including radiotherapy, autologous stem cell transplantation and targeted therapy according to the clinical characteristics and molecular heterogeneity. In this review, we present an overview of the key molecular pathways, prognosis assessment and innovative therapies in primary extranodal DLBCLs.

show abstract

The radiological spectrum of pulmonary lymphoproliferative disease

Cited by 173 publications

References 48 publications

Peripheral T-cell lymphoma unspecified type presenting with a pneumothorax as the initial manifestation: A case report and literature review

Peripheral T-cell lymphoma unspecified type presenting with a pneumothorax as the initial manifestation: A case report and literature review

Lymphoproliferative lung disorders: clinicopathological aspects

Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis

Contact Info

Product

Resources

About