The Radioactive Phosphorus Uptake Test in Diagnosis of Uveal Melanoma

The 32P test and other methods in the diagnosis of intraocular tumours

“…This threshold value of 60% was adopted from Hagler et al (1970), together with other features of their approach to the 32p test, such as the dose, the interval between administration and measurement, and the counting method. During this study, a a2p test result of at least 60% was considered positive and suggestive of a malignant tumour, a result of less than 60% as negative and suggestive of a benign lesion.…”

“…After promising results were reported for 32p testing based on reliable methods and instruments (Hagler et al, 1970;Lommatzsch & Guntermann, 1971;Vogel & StriStges, 1971) The material in which the present study was performed comprised 211 patients examined with the 32p test between March of 1973 and January of 1977, all of whom had an intraocular lesion thought to be malignant. Most of these patients were examined with radioactive technetium, fluorescein angiography, and perimetry.…”

A mathematical analogue to calculate the counts from 32P in the choroidal blood during the 32P uptake test.

“…Results from4 patients showing the 32P activity in blood sample, the predicted choroidal contribution to counts recorded on the eye, and counts recorded from a control site in the unaffected eye More recently ultrasound measurements in living eyes have shown that choroidal thickness is about 400 ,um. 4 If the choroidal blood is regarded as a uniform layer 200 /Arm thick, 400 ,um below the surface of the eye, according to the model, about 6% of the control counts at 48 hours are due to 32P in the blood.…”