The quality of sleep in patients with coeliac disease

Zingone, Fabiana; Siniscalchi, Mario; Capone, P.; Tortora, Raffaella; Andreozzi, Paolo; Capone, Elisa; Ciacci, Carolina

doi:10.1111/j.1365-2036.2010.04432.x

Cited by 63 publications

(56 citation statements)

References 20 publications

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“…For instance, Addolorato et al [61] suggested that a transitory ‘state' anxiety, but not personality ‘trait' anxiety, affected CD patients. The association of depression with CD has been described for more than 20 years [64,65]. A recent study by our group [66] demonstrated an increased prevalence of depressive symptoms in untreated CD patients.…”

Section: Neurologic and Psychiatric Manifestations In CDmentioning

confidence: 96%

Extraintestinal Manifestations of Celiac Disease

Pinto-Sanchez¹,

Berčík²,

Verdú³

et al. 2015

Dig Dis

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Case finding for celiac disease (CD) is becoming increasingly common practice and is conducted in a wide range of clinical situations ranging from the presence of gastrointestinal symptoms to failure to thrive in children, prolonged fatigue, unexpected weight loss and anemia. Case finding is also performed in associated conditions, such as autoimmune thyroid disease, dermatitis herpetiformis and type 1 diabetes, as well as in patients with irritable bowel syndrome, unexplained neuropsychiatric disorders and first-degree relatives of patients with diagnosed CD. This aggressive active case finding has dramatically changed the clinical characteristics of newly diagnosed patients. For instance, higher numbers of patients who present with extraintestinal symptoms are now being diagnosed with CD. Current recommendations state that due to a high risk for complications if the disease remains undiagnosed, patients with extraintestinal symptoms due to CD require appropriate diagnosis and treatment. Despite criticism regarding the cost-effectiveness of case finding in CD, such an aggressive approach has been considered cost-effective for high-risk patients. The diagnosis of CD among patients with extraintestinal symptoms requires a high degree of awareness of the clinical conditions that carry a high risk for underlying CD. Also, understanding the correct use of specific serology and duodenal histology is key for an appropriate diagnostic approach. Both procedures combined are able to confirm diagnosis in the vast majority of cases. However, in certain circumstances, serology and even duodenal histology cannot confirm or rule out CD. A common cause of negative IgA serology is IgA deficiency. For such eventuality, IgG-based serological tests can help confirm the diagnosis. Importantly, some histologically diagnosed cases still remain seronegative despite exclusion of IgA deficiency. On the other hand, duodenal histology may be normal despite the presence of CD-specific antibodies and active CD. This has been clearly demonstrated in some cases of untreated dermatitis herpetiformis, but may also be due to the patchy condition of CD or lesions that are not adequately recognized by nonexpert endoscopists and/or pathologists. The effectiveness of agluten-free diet depends on the clinical end point addressed. A good example is the outcome of bone loss. While risk for fracture normalizes after the first year of dietary treatment, bone parameters measured by densitometry may not be normalized in the long-term follow-up. Moreover, it is still unclear how far an early gluten-free diet will positively affect associated autoimmune diseases like type 1 diabetes and autoimmune thyroiditis.

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Section: Neurologic and Psychiatric Manifestations In CDmentioning

confidence: 96%

Extraintestinal Manifestations of Celiac Disease

Pinto-Sanchez¹,

Berčík²,

Verdú³

et al. 2015

Dig Dis

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“…58 Perhaps more surprisingly, fatigue was not significantly different between newly diagnosed celiac patients and those on an established GFD. The same researchers from Naples have since shown that both treated and untreated celiac patients experience a worse quality of sleep than healthy volunteers 57 perhaps offering an explanation of the mechanisms behind this condition. Again, treated celiac patients did not show significantly different characteristics compared with their untreated counterparts.…”

Section: Fatiguementioning

confidence: 99%

“…Using the modified Self-Rating Depression Scale, Addolorato et al 51 described persistent depression after one year of GFD in celiac patients, Zingone et al 57 and Siniscalchi et al 58 showed that depression was present in CD at diagnosis, but that it persisted or even worsened in patients on a GFD. Nachman et al, 44 using the Beck Depression Inventory, showed that depressive symptoms were highly prevalent in untreated CD and there was a significant improvement in psychological symptoms after one year and four years of GFD.…”

Section: Depressionmentioning

confidence: 99%

“…Depression and anxiety may be associated with other factors including an unsatisfactory sexual life, 13 fatigue 58 and poor quality of sleep. 57 Furthermore, functional disorders, such as IBS [72][73][74] and functional dyspepsia 74,75 are frequently diagnosed in CD patients at diagnosis and in those on a long-term GFD. Since these disorders are also associated with reduced QoL and increase the likelihood of anxiety and depression in CD, 76,77 treating these comorbidities may improve QOL and mood disorders in CD.…”

Section: Mechanisms Explaining Psychological Morbiditiesmentioning

confidence: 99%

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Psychological morbidity of celiac disease: A review of the literature

et al. 2015

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“…Anxiety has been associated with celiac disease in some studies [4,5,13,14], while others found no association [7,10,18,23]. Even fewer studies have addressed the association between celiac disease and attention deficit hyperactivity disorder [10,24], bipolar disorder [10,17,19], and fatigue [11,25,26].…”

Section: Introductionmentioning

confidence: 99%

Psychotropic Medication Use Among Patients with Celiac Disease

et al. 2017

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Background: Celiac disease is a multi-system disorder with manifestations that may result in psychiatric disorders. We assessed the prevalence of medication use to treat psychiatric disorders in celiac disease patients. Methods: We conducted a cross-sectional study of patients undergoing esophagogastroduodenoscopy over 9-years at a celiac disease referral center. We compared the prevalence of psychotropic medication use among celiac disease patients (n = 1293) to a control group (n = 1401) with abdominal pain or reflux. Results: Among all patients the mean age was 48.4 years, most were female (69.5%), and 22.7% used any psychotropic medication. There was no difference between overall psychotropic medication use among celiac disease patients and controls (23.9% vs 21.8%, OR 1.16; 95% CI 0.96-1.39, p = 0.12). However, those with celiac disease were more likely to use antidepressants on univariate (16.4% vs 13.4%, p = 0.03) and multivariate analysis (OR 1.28; 95% CI 1.03-1.59; p = 0.03). Use of psychotropic medications was not associated with disease duration or mode of presentation of celiac disease. Conclusions: Celiac disease patients use psychotropic medications at similar rates as those with other gastrointestinal diseases, though subgroup analysis suggests they may use more antidepressants. Future studies should investigate whether celiac disease is associated with mood disorders that are not treated with medications.

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The quality of sleep in patients with coeliac disease

Abstract: SUMMARY BackgroundCoeliac disease is a chronic disease with a various clinical presentation, including anxiety and depression.

Cited by 63 publications

References 20 publications

Extraintestinal Manifestations of Celiac Disease

Extraintestinal Manifestations of Celiac Disease

Psychological morbidity of celiac disease: A review of the literature

Psychotropic Medication Use Among Patients with Celiac Disease

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