Psychological morbidity of celiac disease: A review of the literature

Abstract

Background: Celiac disease has been linked to decreased quality of life and certain mood disorders. The effect of the gluten free diet on these psychological aspects of the disease is still unclear.

The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis

“…The reference lists of included papers and previous reviews (Smith & Gerdes, 2012;Zingone et al, 2015) were additionally hand-searched for any relevant papers (KS).…”

“…Undiagnosed or poorly managed, CD is associated with gastrointestinal and malabsorption symptoms and increased risk of long-term health complications, including intestinal cancers, osteoporosis, and infertility (Green & Cellier, 2007;Green & Jabri, 2003). Depression is also often cited as a symptom of undiagnosed CD (Jackson, Eaton, Cascella, Fasano, & Kelly, 2012), and clinically diagnosed depression and/or depressive symptoms (typically collapsed in reviews) appear to occur with greater frequency and/or severity in CD than healthy samples (Smith & Gerdes, 2012;Zingone et al, 2015).…”

“…The literature on a comparable relationship between depression and GFD adherence in CD patients has yet to be synthesised, with existing reviews on the incidence of depression in CD (Smith & Gerdes, 2012;Zingone et al, 2015) being methodologically unable to answer the more specific question regarding GFD adherence. Firstly, evidence for the depression-adherence association comes primarily from studies assessing differences in depression between newly-diagnosed patients and those already being managed on a GFD, without assessment of the adequacy of dietary adherence in the established gluten free patients.…”

Impacts on education in Children with Celiac disease

“…Unfortunately, the mechanism how celiac disease increases the risk of psychiatric problems has not been explained up to now, however, it is probably a consequence of malnutrition that affects normal brain function (Zingone et al, 2015).…”

Managing fatigue in patients with Parkinson's disease: a patient-focused perspective

“…3 It is this type of fatigue that is a frequent non-motor symptom of Parkinson's disease (PD) and other chronic illnesses. 1,[4][5][6] Fatigue has only been recently recognized as a common problem in PD. 7,8 Over half of PD patients consider fatigue among their most disabling symptoms, [8][9][10] and yet fatigue often goes unrecognized and is not addressed by neurologists.…”