The QT &gt; QS2 syndrome: A new mortality risk indicator in coronary artery disease

Boudoulas, Harisios; Sohn, Young H.; O’Neill, William W.; Brown, Roger; Weissler, Arnold M.

doi:10.1016/0002-9149(82)90454-4

Cited by 70 publications

(33 citation statements)

References 17 publications

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“…The adoption of Bazett's formula to cor rect Q -T m might be questionable, since this calculation is considered misleading by some authors [19], To further evaluate the actual Q-T interval duration in our three groups of subjects, we also used Q -T/Q -Si ratio, since Q-T seems to be more closely linked to the duration of electromechanical systole than to heart rate [9], Again, a higher Q -T/Q -S2 ratio was observed in both young and adult athletes in comparison with untrained indi viduals.…”

Section: Discussionmentioning

confidence: 99%

“…Q -T interval was expressed as measured Q -T (Q -T m), and as Q -T corrected (Q -T c) according to Bazett's for mula [8]. In addition, the ratio of electrical to me chanical systole was calculated [9], Q -Si interval was measured from the beginning of the Q wave of the ECG to the closure of the aortic valve of the echocar diogram. Ten consecutive Q -T and Q -S2 intervals were measured and subsequently averaged.…”

Section: Q -T Intervalmentioning

confidence: 99%

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Effect of Endurance Training on Q-T Interval and Cardiac Electrical Stability in Boys Aged 10 to 14

Palatini

Maraglino²,

Mos³

et al. 1987

Cardiology

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In 30 highly trained boys aged 10-14 the prevalence of ventricular ectopic beats and Q-T interval duration were studied. In trained boys ECG Holter monitoring showed a higher even though not significantly different prevalence of ventricular arrhythmias than in 30 age-matched untrained controls. Ventricular ectopy was on the contrary lower than in a group of 30 adult athletes. Q-T corrected (Q-T_c) interval in the trained boys was longer than in the sedentary controls (p < 0.001), while it was as long as in the adult athletes. No correlation was found between the degree of severity of ventricular ectopic beats and Q-T_cinterval duration, heart rate or echocardiographic dimensional and functional findings. The clinical and prognostic importance of complex ventricular arrhythmias detected in healthy athletes remains to be elucidated.

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Section: Discussionmentioning

confidence: 99%

Section: Q -T Intervalmentioning

confidence: 99%

Effect of Endurance Training on Q-T Interval and Cardiac Electrical Stability in Boys Aged 10 to 14

Palatini

Maraglino²,

Mos³

et al. 1987

Cardiology

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“…Patient groups with normal (< 56 mm), moderately increased (56-60) and markedly increased LVEDD (>60 mm) exhibited decreasing survival with increasing LVEDD (p = 0.0002). Multivariate analysis demonstrated that the LVEDD adds significantly to the risk stratification potency of left ventricular systolic function determined from the systolic time intervals.[ [4][5][6][7] have corroborated the poor prognosis among pa tients with previous myocardial infarction and cardio megaly on routine chest roentgenograms.Echocardiography [8] is now well established as a sen sitive noninvasive modality for quantitating left ventric ular (LV) size. On the basis of the above studies, we hypothesized that noninvasive measurement of LV enddiastolic diameter (LVEDD) by M-mode echocardiogra-…”

mentioning

confidence: 83%

Left Ventricular End-Diastolic Diameter as a Risk Indicator in Coronary Artery Disease

Weissler¹,

Vohra²,

Sohn³

et al. 1987

Am J Noninvas Cardiol

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Previous studies have demonstrated that the presence of cardiomegaly on the routine chest roentgenogram in patients with coronary artery disease (CAD) constitutes a high-risk prognostic indicator. This study was designed to test the value of the measurement of the left ventricular end-diastolic diameter (LVEDD) on echocardiography, a more precise measure of left ventricular size than is offered by the routine chest roentgenogram, as a mortality risk indicator in patients with previous myocardial infarction. One hundred and twenty-three patients observed at an average of 14 months post-myocardial infarction, with a mean follow-up of 44 months, were studied. The normal mean ± 1 SD for LVEDD was 47.2 ± 4.3 mm. The upper normal limit of LVEDD was set at +2 SD from the normal mean (56 mm). Fifty-two patients had increased LVEDD (> 56 mm) and the remaining 71 had normal LVEDD (<56 mm). There were 28 cardiac deaths. Cumulative 5-year survival was 88% in patients with normal LVEDD and 55% in those with increased LVEDD (p = 0.0002). Patient groups with normal (< 56 mm), moderately increased (56-60) and markedly increased LVEDD (>60 mm) exhibited decreasing survival with increasing LVEDD (p = 0.0002). Multivariate analysis demonstrated that the LVEDD adds significantly to the risk stratification potency of left ventricular systolic function determined from the systolic time intervals.

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“…Changes in autonomic tone are associated with an inversion of this normal EM coupling ratio; this ratio has been singled out as a useful indicator of several cardiovascular diseases, such as "the QT>QS 2 Syndrome." 16 Notice that the highly different configurations of the QRS complexes stem from differences in ventricular activation that stem from differences in distribution of Purkinje fibers and are underlined by differences in the EMw, leading to shorter QT and longer EMw in swine ( Figure 3). Variations in cardiovascular parameters, such as the QRS complexes, do also occur among the different lineages of minipigs and should be considered when constructing experimental designs (cf Figure 1(a) and Table 2).…”

Section: Sinclairmentioning

confidence: 99%

Comparative cardiovascular physiology and pathology in selected lineages of minipigs

Stricker–Krongrad

Shoemake

Brocksmith

et al. 2017

Toxicology Research and Application

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The minipig has been increasingly recognized as a valid alternative to canines and nonhuman primates in regulatory toxicity. This article presents the results of cardiovascular assessments in the Yucatan, Hanford, Sinclair, and Göttingen minipigs conducted during nonclinical investigations and control toxicity testing. Cardiac electrophysiology was obtained using clinical electrocardiogram and surgical monitor units. Peripheral vessel diameter, velocity, and flow were obtained by Doppler ultrasonography, and cardiac vessel diameter was obtained postmortem. Anatomic parameters were obtained at necropsy. Histopathology assessments were conducted on heart, blood vessels, and kidneys. Collected data were compared to published cardiovascular measurements of adult humans to illustrate similarities and differences. Each lineage of minipigs was found to have specific anatomic and physiologic characteristics that may accurately reflect response of human cardiovascular systems in clinical investigations and toxicity testing. In conclusion, the interspecies similarities between the cardiovascular systems make these lineages of minipigs suitable as models for the human counterpart. In addition, these reported differences between lineages will aid investigators in selecting a relevant lineage of minipigs if specific cardiovascular parameters are required during drug safety evaluation.

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The QT > QS2 syndrome: A new mortality risk indicator in coronary artery disease

Cited by 70 publications

References 17 publications

Effect of Endurance Training on Q-T Interval and Cardiac Electrical Stability in Boys Aged 10 to 14

Effect of Endurance Training on Q-T Interval and Cardiac Electrical Stability in Boys Aged 10 to 14

Left Ventricular End-Diastolic Diameter as a Risk Indicator in Coronary Artery Disease

Comparative cardiovascular physiology and pathology in selected lineages of minipigs

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